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Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29699, updated on 4-Jan-2025

Summary

Official Symbol
Prkar2aprovided by RGD
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit alphaprovided by RGD
Primary source
RGD:3393
See related
EnsemblRapid:ENSRNOG00000020284 AllianceGenome:RGD:3393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including beta-2 adrenergic receptor binding activity; cAMP binding activity; and cAMP-dependent protein kinase regulator activity. Involved in regulation of protein kinase activity. Located in T-tubule and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 500.4), Kidney (RPKM 256.3) and 9 other tissues See more
Orthologs
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Genomic context

See Prkar2a in Genome Data Viewer
Location:
8q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118271608..118337332)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109393189..109458832)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117486085..117548768)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC120094262 Neighboring gene solute carrier family 25 member 20 Neighboring gene uncharacterized LOC134480235 Neighboring gene uncharacterized LOC134480236 Neighboring gene small nucleolar RNA SNORA28 Neighboring gene inositol hexakisphosphate kinase 2 Neighboring gene NCK interacting protein with SH3 domain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-2 adrenergic receptor binding PubMed 
enables cAMP binding  
enables cAMP binding PubMed 
enables cAMP binding  
enables cAMP-dependent protein kinase inhibitor activity  
enables cAMP-dependent protein kinase inhibitor activity  
enables cAMP-dependent protein kinase inhibitor activity  
enables cAMP-dependent protein kinase regulator activity PubMed 
enables cAMP-dependent protein kinase regulator activity  
enables identical protein binding PubMed 
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding PubMed 
enables protein domain specific binding  
enables protein kinase A catalytic subunit binding  
enables protein kinase A catalytic subunit binding PubMed 
enables protein kinase A catalytic subunit binding  
enables protein kinase A catalytic subunit binding  
enables protein-containing complex binding PubMed 
enables small molecule binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Items 1 - 20 of 25
Component Evidence Code Pubs
located_in T-tubule PubMed 
located_in axoneme  
located_in axoneme  
part_of cAMP-dependent protein kinase complex  
part_of cAMP-dependent protein kinase complex PubMed 
part_of cAMP-dependent protein kinase complex  
part_of cAMP-dependent protein kinase complex  
located_in centrosome  
located_in centrosome  
located_in cytoplasm  
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in germinal vesicle  
is_active_in glutamatergic synapse  
part_of nucleotide-activated protein kinase complex  
part_of nucleotide-activated protein kinase complex  
located_in perinuclear region of cytoplasm PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane raft  
located_in plasma membrane raft  
part_of protein-containing complex PubMed 
part_of protein-containing complex  
is_active_in synapse  
Items 1 - 20 of 25

General protein information

Preferred Names
cAMP-dependent protein kinase type II-alpha regulatory subunit
Names
protein kinase cAMP-dependent type 2 regulatory subunit alpha
protein kinase, cAMP dependent regulatory, type II alpha
protein kinase, cAMP-dependent, regulatory subunit type II alpha
protein kinase, cAMP-dependent, regulatory, type 2, alpha
NP_062137.1
XP_038936901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019264.2NP_062137.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_062137.1

    Status: PROVISIONAL

    Source sequence(s)
    AF533978
    UniProtKB/Swiss-Prot
    G3V8Q6, P12368, Q8K1M2
    Related
    ENSRNOP00000027552.2, ENSRNOT00000027552.5
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:252368
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:258379
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118271608..118337332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080973.2XP_038936901.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1

    Conserved Domains (1) summary
    cd00038
    Location:176297
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
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