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    Adra1b adrenoceptor alpha 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24173, updated on 4-Jan-2025

    Summary

    Official Symbol
    Adra1bprovided by RGD
    Official Full Name
    adrenoceptor alpha 1Bprovided by RGD
    Primary source
    RGD:2054
    See related
    EnsemblRapid:ENSRNOG00000060087 AllianceGenome:RGD:2054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables alpha1-adrenergic receptor activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration; response to estrogen; and response to steroid hormone. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and intercalated disc. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 65.5), Liver (RPKM 43.0) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Adra1b in Genome Data Viewer
    Location:
    10q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28756461..28874831, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28255025..28373418, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29392762..29450644, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene PWWP domain containing 2A Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene uncharacterized LOC108352076 Neighboring gene uncharacterized LOC134480677 Neighboring gene uncharacterized LOC134480631

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha1-adrenergic receptor activity  
    enables alpha1-adrenergic receptor activity PubMed 
    enables alpha1-adrenergic receptor activity  
    enables alpha1-adrenergic receptor activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in adrenergic receptor signaling pathway  
    acts_upstream_of_or_within adult heart development  
    acts_upstream_of_or_within behavioral response to cocaine  
    acts_upstream_of_or_within blood vessel remodeling  
    acts_upstream_of_or_within cell growth involved in cardiac muscle cell development  
    involved_in cell-cell signaling  
    acts_upstream_of_or_within glucose homeostasis  
    acts_upstream_of glycogen catabolic process  
    acts_upstream_of_or_within locomotory behavior  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction PubMed 
    acts_upstream_of_or_within negative regulation of glycogen catabolic process  
    involved_in neuron-glial cell signaling  
    acts_upstream_of_or_within organ growth  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    acts_upstream_of_or_within positive regulation of glycogen catabolic process  
    acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine  
    acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine  
    involved_in regulation of blood pressure  
    involved_in regulation of cardiac muscle contraction  
    involved_in regulation of vasoconstriction  
    acts_upstream_of_or_within response to amphetamine  
    involved_in response to estrogen PubMed 
    involved_in response to hormone PubMed 
    acts_upstream_of_or_within response to morphine  
    involved_in response to steroid hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure  
    acts_upstream_of_or_within visual learning  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    located_in T-tubule PubMed 
    located_in caveola  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intercalated disc PubMed 
    located_in membrane  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleus  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    alpha-1B adrenergic receptor
    Names
    Adrenergic alpha 1B- receptor
    adrenergic receptor, alpha 1b
    adrenergic, alpha-1B-, receptor
    alpha-1B adrenoceptor
    alpha-1B adrenoreceptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429872.1NP_001416801.1  alpha-1B adrenergic receptor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P15823, Q63215
      UniProtKB/TrEMBL
      A0A0G2K564, Q6IRH4
    2. NM_016991.3NP_058687.2  alpha-1B adrenergic receptor

      See identical proteins and their annotated locations for NP_058687.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P15823, Q63215
      UniProtKB/TrEMBL
      A0A0G2K564, Q6IRH4
      Related
      ENSRNOP00000073309.2, ENSRNOT00000087937.3
      Conserved Domains (1) summary
      cd15326
      Location:46359
      7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      28756461..28874831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085165.2XP_038941093.1  alpha-1B adrenergic receptor isoform X1

      Conserved Domains (1) summary
      cd15326
      Location:46359
      7tmA_alpha1B_AR; alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_063268387.1XP_063124457.1  alpha-1B adrenergic receptor isoform X2

    3. XM_063268388.1XP_063124458.1  alpha-1B adrenergic receptor isoform X2

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