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Slc39a10 solute carrier family 39 (zinc transporter), member 10 [ Mus musculus (house mouse) ]

Gene ID: 227059, updated on 4-Jan-2025

Summary

Official Symbol
Slc39a10provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 10provided by MGI
Primary source
MGI:MGI:1914515
See related
Ensembl:ENSMUSG00000025986 AllianceGenome:MGI:1914515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip10; mKIAA1265; 5430433I10; 2900042E17Rik
Summary
Enables protein tyrosine phosphatase activator activity and zinc ion transmembrane transporter activity. Involved in epithelial to mesenchymal transition. Acts upstream of or within several processes, including positive regulation of B cell proliferation; positive regulation of B cell receptor signaling pathway; and zinc ion import across plasma membrane. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; brain; ovary; sensory organ; and urinary system. Orthologous to human SLC39A10 (solute carrier family 39 member 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in cortex adult (RPKM 17.1), frontal lobe adult (RPKM 14.5) and 22 other tissues See more
Orthologs
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Genomic context

See Slc39a10 in Genome Data Viewer
Location:
1 C1.1; 1 24.07 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (46846704..46964952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (46807544..46925776, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 8 pseudogene Neighboring gene dynein, axonemal, heavy chain 7C Neighboring gene STARR-seq mESC enhancer starr_00829 Neighboring gene STARR-seq mESC enhancer starr_00830 Neighboring gene STARR-positive B cell enhancer mm9_chr1:46910239-46910540 Neighboring gene STARR-positive B cell enhancer mm9_chr1:46910886-46911186 Neighboring gene STARR-seq mESC enhancer starr_00836 Neighboring gene STARR-seq mESC enhancer starr_00838 Neighboring gene STARR-seq mESC enhancer starr_00839 Neighboring gene STARR-seq mESC enhancer starr_00842 Neighboring gene STARR-seq mESC enhancer starr_00843 Neighboring gene STARR-seq mESC enhancer starr_00844 Neighboring gene STARR-seq mESC enhancer starr_00845 Neighboring gene predicted gene, 39638 Neighboring gene STARR-seq mESC enhancer starr_00846 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
zinc transporter ZIP10
Names
ZIP-10
solute carrier family 39 member 10
zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356416.1NP_001343345.1  zinc transporter ZIP10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116452, AC124185
    Consensus CDS
    CCDS14936.1
    UniProtKB/Swiss-Prot
    Q6P5F6, Q80TG2, Q8BX42, Q8C0L2
    Conserved Domains (1) summary
    pfam02535
    Location:406821
    Zip; ZIP Zinc transporter
  2. NM_001356417.1NP_001343346.1  zinc transporter ZIP10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC109276, AC116452, AC124185
    Consensus CDS
    CCDS14936.1
    UniProtKB/Swiss-Prot
    Q6P5F6, Q80TG2, Q8BX42, Q8C0L2
    Conserved Domains (1) summary
    pfam02535
    Location:406821
    Zip; ZIP Zinc transporter
  3. NM_172653.3NP_766241.2  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_766241.2

    Status: VALIDATED

    Source sequence(s)
    AC116452, AC124185
    Consensus CDS
    CCDS14936.1
    UniProtKB/Swiss-Prot
    Q6P5F6, Q80TG2, Q8BX42, Q8C0L2
    Related
    ENSMUSP00000027131.5, ENSMUST00000027131.6
    Conserved Domains (1) summary
    pfam02535
    Location:406821
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    46846704..46964952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164377.1XP_036020270.1  zinc transporter ZIP10 isoform X2

    UniProtKB/Swiss-Prot
    Q6P5F6, Q80TG2, Q8BX42, Q8C0L2
    Conserved Domains (1) summary
    pfam02535
    Location:406821
    Zip; ZIP Zinc transporter
  2. XM_006495932.3XP_006495995.1  zinc transporter ZIP10 isoform X1

    Conserved Domains (1) summary
    pfam02535
    Location:416831
    Zip; ZIP Zinc transporter
  3. XM_006495933.5XP_006495996.1  zinc transporter ZIP10 isoform X2

    See identical proteins and their annotated locations for XP_006495996.1

    UniProtKB/Swiss-Prot
    Q6P5F6, Q80TG2, Q8BX42, Q8C0L2
    Conserved Domains (1) summary
    pfam02535
    Location:406821
    Zip; ZIP Zinc transporter
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