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Vtn vitronectin [ Mus musculus (house mouse) ]

Gene ID: 22370, updated on 13-Jan-2025

Summary

Official Symbol
Vtnprovided by MGI
Official Full Name
vitronectinprovided by MGI
Primary source
MGI:MGI:98940
See related
Ensembl:ENSMUSG00000017344 AllianceGenome:MGI:98940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vn
Summary
Enables extracellular matrix binding activity. Involved in oligodendrocyte differentiation. Acts upstream of or within cell-matrix adhesion; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver adult (RPKM 833.3), liver E18 (RPKM 554.4) and 2 other tissues See more
Orthologs
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Genomic context

See Vtn in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78389946..78393151)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78499120..78502325)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Neighboring gene solute carrier family 46, member 1 Neighboring gene sterile alpha and HEAT/Armadillo motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene SEBOX homeobox Neighboring gene transmembrane protein 199

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding  
enables collagen binding  
enables extracellular matrix binding  
enables extracellular matrix binding PubMed 
enables extracellular matrix structural constituent PubMed 
enables heparin binding  
enables heparin binding  
enables identical protein binding  
enables identical protein binding  
enables integrin binding  
enables integrin binding  
enables integrin binding  
enables polysaccharide binding  
enables scavenger receptor activity  
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin  
involved_in cell adhesion mediated by integrin  
involved_in cell adhesion mediated by integrin  
involved_in cell migration  
involved_in cell migration  
involved_in cell-matrix adhesion  
acts_upstream_of_or_within cell-matrix adhesion PubMed 
involved_in cell-matrix adhesion  
involved_in endodermal cell differentiation  
involved_in endodermal cell differentiation  
acts_upstream_of_or_within extracellular matrix organization PubMed 
involved_in immune response  
involved_in liver regeneration  
involved_in liver regeneration  
involved_in negative regulation of endopeptidase activity  
involved_in negative regulation of fibrinolysis PubMed 
involved_in oligodendrocyte differentiation PubMed 
acts_upstream_of_or_within positive regulation of cell-substrate adhesion PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of protein binding  
involved_in positive regulation of receptor-mediated endocytosis  
involved_in positive regulation of receptor-mediated endocytosis  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell migration  
involved_in protein polymerization  
involved_in protein polymerization  
involved_in regulation of cell adhesion  
involved_in smooth muscle cell-matrix adhesion  
involved_in smooth muscle cell-matrix adhesion  
involved_in vesicle-mediated transport  
Items 1 - 25 of 31
Component Evidence Code Pubs
located_in Golgi lumen  
located_in Golgi lumen  
located_in basement membrane  
located_in basement membrane  
located_in collagen-containing extracellular matrix PubMed 
is_active_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix PubMed 
located_in endoplasmic reticulum  
located_in extracellular matrix PubMed 
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in intracellular membrane-bounded organelle  
part_of peptidase inhibitor complex  
part_of protein complex involved in cell-matrix adhesion  
located_in rough endoplasmic reticulum lumen  
located_in rough endoplasmic reticulum lumen  

General protein information

Preferred Names
vitronectin
Names
S-protein
serum-spreading factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011707.2NP_035837.1  vitronectin precursor

    See identical proteins and their annotated locations for NP_035837.1

    Status: VALIDATED

    Source sequence(s)
    AI173462, AK090325, CK617609
    Consensus CDS
    CCDS25106.1
    UniProtKB/Swiss-Prot
    P29788, Q5SYG4, Q8VII4, Q91X32, Q9D080
    Related
    ENSMUSP00000017488.5, ENSMUST00000017488.5
    Conserved Domains (2) summary
    smart00201
    Location:2062
    SO; Somatomedin B -like domains
    cd00094
    Location:153473
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78389946..78393151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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