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Ctsj cathepsin J [ Mus musculus (house mouse) ]

Gene ID: 26898, updated on 4-Jan-2025

Summary

Official Symbol
Ctsjprovided by MGI
Official Full Name
cathepsin Jprovided by MGI
Primary source
MGI:MGI:1349426
See related
Ensembl:ENSMUSG00000055298 AllianceGenome:MGI:1349426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CATP; Ctsp; CatRLP
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including brain; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward placenta adult (RPKM 1014.2) See more
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Genomic context

See Ctsj in Genome Data Viewer
Location:
13 B2; 13 32.62 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61147993..61153739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61000179..61005925, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40976 Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40975 Neighboring gene cathepsin Q Neighboring gene STARR-seq mESC enhancer starr_34744 Neighboring gene zinc finger protein 930 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Clone Names

  • MGC117662

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteolysis  
involved_in proteolysis involved in protein catabolic process  
Component Evidence Code Pubs
is_active_in extracellular space  
is_active_in lysosome  
located_in lysosome  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
cathepsin J
Names
Cat P
cathepsin L-related protein
cathepsin P
catlrp-p
gene/Cathepsin L-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356291.1NP_001343220.1  cathepsin J isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AK005526
    Consensus CDS
    CCDS88467.1
    UniProtKB/Swiss-Prot
    Q564D9, Q91XK6, Q9R014, Q9WV51
    Related
    ENSMUSP00000153389.2, ENSMUST00000224224.2
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114331
    Peptidase_C1; Papain family cysteine protease
  2. NM_012007.2NP_036137.1  cathepsin J isoform 2 precursor

    See identical proteins and their annotated locations for NP_036137.1

    Status: VALIDATED

    Source sequence(s)
    AF136272, AK005526, AK131661
    Consensus CDS
    CCDS49291.1
    UniProtKB/TrEMBL
    A0A0R4J0V8
    Related
    ENSMUSP00000071457.5, ENSMUST00000071526.6
    Conserved Domains (2) summary
    smart00848
    Location:2986
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:113330
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61147993..61153739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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