Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
HIV-1 Nef utilizes beta-COP in CD28 downregulation |
PubMed
|
|
nef
|
beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation |
PubMed
|
|
nef
|
MHC-I is found in the Rab7(+) vesicles and targeted for degradation via the activity of the Nef-interacting protein, beta-COP |
PubMed
|
|
nef
|
Binding of HIV-1 Nef to Beta-COP has been demonstrated by yeast two-hybrid and coimmunoprecipitation experiments and may be involved in the downregulation of CD4 by Nef |
PubMed
|
|
nef
|
Co-localization of HIV-1 Nef, ARF1, and Beta-COP in early endosomes depends on Nef residues at E154 and E155; this co-localization is required for the downregulation and transport of CD4 to acidic late-endosomal compartments |
PubMed
|
Go to the HIV-1, Human Interaction Database