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MAPKAPK2 MAPK activated protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 9261, updated on 4-Jan-2025

Summary

Official Symbol
MAPKAPK2provided by HGNC
Official Full Name
MAPK activated protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:6887
See related
Ensembl:ENSG00000162889 MIM:602006; AllianceGenome:HGNC:6887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MK2; MK-2; MAPKAP-K2
Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 54.9), heart (RPKM 45.1) and 25 other tissues See more
Orthologs
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Genomic context

See MAPKAPK2 in Genome Data Viewer
Location:
1q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206684905..206734281)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205949085..205998488)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (206858250..206907626)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1760 Neighboring gene DYRK3 antisense RNA 1 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 3 Neighboring gene uncharacterized LOC124904496 Neighboring gene Sharpr-MPRA regulatory region 10950 Neighboring gene uncharacterized LOC124904495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1764 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206860855-206861416 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:206861417-206861978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2412 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:206895773-206896486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2417 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:206937123-206937321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene interleukin 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene interleukin 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway PubMed
Vpr vpr Kinase Srk1/MK2 is required for the Vpr-mediated nuclear export of Cdc25 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 31
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables calcium-dependent protein serine/threonine kinase activity  
enables calcium/calmodulin-dependent protein kinase activity  
enables calmodulin binding  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables mitogen-activated protein kinase binding  
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 31
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization PubMed 
involved_in DNA damage response PubMed 
involved_in MAPK cascade PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus  
involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
involved_in chromatin remodeling  
involved_in inflammatory response  
involved_in inflammatory response  
involved_in inner ear development  
involved_in intracellular signal transduction  
involved_in leukotriene metabolic process  
involved_in macropinocytosis  
involved_in p38MAPK cascade  
involved_in peptidyl-serine phosphorylation PubMed 
involved_in positive regulation of macrophage cytokine production  
involved_in positive regulation of tumor necrosis factor production  
involved_in protein phosphorylation PubMed 
involved_in regulation of cellular response to heat  
involved_in regulation of interleukin-6 production  
involved_in regulation of mRNA stability  
involved_in regulation of tumor necrosis factor production PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway  
involved_in response to cytokine  
involved_in response to cytokine PubMed 
involved_in response to lipopolysaccharide  
involved_in toll-like receptor signaling pathway  
involved_in toll-like receptor signaling pathway  
involved_in vascular endothelial growth factor receptor signaling pathway  
involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway  
Items 1 - 25 of 30
Component Evidence Code Pubs
located_in centrosome  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
MAP kinase-activated protein kinase 2
Names
MAPKAP kinase 2
mitogen-activated protein kinase-activated protein kinase 2
NP_004750.1
NP_116584.2
XP_005273410.1
XP_016858299.1
XP_047290374.1
XP_054195605.1
XP_054195606.1
XP_054195607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029640.1 RefSeqGene

    Range
    4886..54262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004759.5NP_004750.1  MAP kinase-activated protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_004750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AL591846, BC036060, BC052584, BU621009
    Consensus CDS
    CCDS1466.1
    UniProtKB/Swiss-Prot
    P49137
    Related
    ENSP00000294981.4, ENST00000294981.8
    Conserved Domains (2) summary
    smart00220
    Location:68325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14170
    Location:61353
    STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2
  2. NM_032960.4NP_116584.2  MAP kinase-activated protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_116584.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL591846, BC036060, BC052584, BU621009
    Consensus CDS
    CCDS31001.1
    UniProtKB/Swiss-Prot
    P49137, Q5SY30, Q5SY41, Q8IYD6
    Related
    ENSP00000356070.4, ENST00000367103.4
    Conserved Domains (1) summary
    cd14170
    Location:61363
    STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    206684905..206734281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273353.4XP_005273410.1  MAP kinase-activated protein kinase 2 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:68325
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14170
    Location:61353
    STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2
  2. XM_017002810.2XP_016858299.1  MAP kinase-activated protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1270
    PKc_like; Protein Kinases, catalytic domain
  3. XM_047434418.1XP_047290374.1  MAP kinase-activated protein kinase 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    205949085..205998488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339630.1XP_054195605.1  MAP kinase-activated protein kinase 2 isoform X1

  2. XM_054339631.1XP_054195606.1  MAP kinase-activated protein kinase 2 isoform X2

  3. XM_054339632.1XP_054195607.1  MAP kinase-activated protein kinase 2 isoform X3

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