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Csn1s2a casein alpha s2-like A [ Mus musculus (house mouse) ]

Gene ID: 12993, updated on 4-Jan-2025

Summary

Official Symbol
Csn1s2aprovided by MGI
Official Full Name
casein alpha s2-like Aprovided by MGI
Primary source
MGI:MGI:88542
See related
Ensembl:ENSMUSG00000061937 AllianceGenome:MGI:88542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csng; PP22
Summary
Predicted to enable protein homodimerization activity and zymogen binding activity. Located in extracellular region. Is expressed in jaw bone; nervous system; sensory organ; and thoracic segment skeleton. Orthologous to human CSN1S2AP (casein alpha s2 like A, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
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Genomic context

See Csn1s2a in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87922309..87936657)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87774450..87788798)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25066 Neighboring gene STARR-seq mESC enhancer starr_13563 Neighboring gene predicted gene, 24314 Neighboring gene casein alpha s2-like B Neighboring gene STARR-seq mESC enhancer starr_13564 Neighboring gene proline rich 27

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity  
enables zymogen binding  
Component Evidence Code Pubs
located_in extracellular region PubMed 
is_active_in extracellular space  

General protein information

Preferred Names
alpha-S2-casein-like A
Names
gamma casein
milk protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304765.1NP_001291694.1  alpha-S2-casein-like A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001291694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC074046, AK164738, BB661763
    Consensus CDS
    CCDS80318.1
    UniProtKB/TrEMBL
    Q3TP41
    Related
    ENSMUSP00000143715.2, ENSMUST00000196749.5
  2. NM_001304767.1NP_001291696.1  alpha-S2-casein-like A isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC074046, AK142688, BB661763
    Consensus CDS
    CCDS84901.1
    UniProtKB/TrEMBL
    A0A0G2JET6
    Related
    ENSMUSP00000142901.2, ENSMUST00000200322.5
  3. NM_001304768.1NP_001291697.1  alpha-S2-casein-like A isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 5), compared to isoform 1.
    Source sequence(s)
    AC074046, AK142688, BB661763
    Consensus CDS
    CCDS84900.1
    UniProtKB/TrEMBL
    A0A0G2JGC6
    Related
    ENSMUSP00000143515.2, ENSMUST00000196585.2
  4. NM_001304769.1NP_001291698.1  alpha-S2-casein-like A isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC074046, AK142688, BB661763
    UniProtKB/TrEMBL
    Q547D1
  5. NM_007785.2NP_031811.1  alpha-S2-casein-like A isoform 1 precursor

    See identical proteins and their annotated locations for NP_031811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC074046, AK142688, BB661763
    Consensus CDS
    CCDS39132.1
    UniProtKB/Swiss-Prot
    Q02862
    UniProtKB/TrEMBL
    Q547D1
    Related
    ENSMUSP00000075716.4, ENSMUST00000076379.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    87922309..87936657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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