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    Nectin2 nectin cell adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308417, updated on 4-Jan-2025

    Summary

    Official Symbol
    Nectin2provided by RGD
    Official Full Name
    nectin cell adhesion molecule 2provided by RGD
    Primary source
    RGD:1309505
    See related
    EnsemblRapid:ENSRNOG00000018730 AllianceGenome:RGD:1309505
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pvrl2
    Summary
    Predicted to enable cell adhesion molecule binding activity; protein homodimerization activity; and receptor ligand activity. Predicted to be involved in several processes, including coreceptor-mediated virion attachment to host cell; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of lymphocyte mediated immunity. Predicted to act upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in several cellular components, including cell surface; cell-cell contact zone; and zonula adherens. Predicted to be active in apical junction complex and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 104.0), Liver (RPKM 99.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nectin2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88500086..88535474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79372123..79407379, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80631449..80666617, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein E Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene basal cell adhesion molecule (Lutheran blood group) Neighboring gene Cbl proto-oncogene C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC94554

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding  
    enables cell adhesion molecule binding  
    enables identical protein binding  
    enables protein homodimerization activity  
    enables receptor ligand activity  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in acrosome assembly  
    acts_upstream_of_or_within acrosome assembly  
    involved_in biological_process  
    acts_upstream_of_or_within cellular anatomical entity morphogenesis  
    acts_upstream_of_or_within cilium organization  
    involved_in coreceptor-mediated virion attachment to host cell  
    acts_upstream_of_or_within cytoskeleton organization  
    acts_upstream_of_or_within establishment of localization in cell  
    acts_upstream_of_or_within establishment of mitochondrion localization  
    acts_upstream_of_or_within fertilization  
    involved_in fusion of virus membrane with host plasma membrane  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
    involved_in natural killer cell mediated cytotoxicity  
    involved_in negative regulation of natural killer cell mediated cytotoxicity  
    involved_in positive regulation of T cell receptor signaling pathway  
    involved_in positive regulation of T cell receptor signaling pathway  
    involved_in positive regulation of immunoglobulin mediated immune response  
    involved_in positive regulation of immunoglobulin mediated immune response  
    involved_in positive regulation of mast cell activation  
    involved_in positive regulation of mast cell activation  
    involved_in positive regulation of natural killer cell mediated cytotoxicity  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  
    involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  
    involved_in regulation of viral entry into host cell  
    acts_upstream_of_or_within sperm mitochondrion organization  
    acts_upstream_of_or_within spermatid development  
    involved_in spermatid development  
    acts_upstream_of_or_within spermatid nucleus differentiation  
    involved_in susceptibility to T cell mediated cytotoxicity  
    involved_in susceptibility to natural killer cell mediated cytotoxicity  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    is_active_in apical junction complex  
    located_in apical junction complex  
    located_in cell surface  
    located_in cell-cell contact zone  
    located_in cell-cell junction  
    located_in membrane  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in zonula adherens  

    General protein information

    Preferred Names
    nectin-2
    Names
    poliovirus receptor related 2
    poliovirus receptor-related 2 (herpesvirus entry mediator B)
    poliovirus receptor-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012064.1NP_001012064.1  nectin-2 precursor

      See identical proteins and their annotated locations for NP_001012064.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090075
      UniProtKB/TrEMBL
      A0A8I6A2S9, Q5FVC5
      Related
      ENSRNOP00000025388.5, ENSRNOT00000025388.8
      Conserved Domains (3) summary
      cd05718
      Location:48150
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:40149
      IG_like; Immunoglobulin like
      cl11960
      Location:153248
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88500086..88535474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228421.4XP_006228483.1  nectin-2 isoform X1

      See identical proteins and their annotated locations for XP_006228483.1

      UniProtKB/TrEMBL
      A0A0G2KA71, A6J8U5
      Conserved Domains (3) summary
      cd05718
      Location:48150
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      smart00410
      Location:40149
      IG_like; Immunoglobulin like
      cl11960
      Location:153248
      Ig; Immunoglobulin domain
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