U.S. flag

An official website of the United States government

PAK3 p21 (RAC1) activated kinase 3 [ Homo sapiens (human) ]

Gene ID: 5063, updated on 4-Jan-2025

Summary

Official Symbol
PAK3provided by HGNC
Official Full Name
p21 (RAC1) activated kinase 3provided by HGNC
Primary source
HGNC:HGNC:8592
See related
Ensembl:ENSG00000077264 MIM:300142; AllianceGenome:HGNC:8592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; XLID30; PAK3beta; beta-PAK
Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Expression
Biased expression in brain (RPKM 8.0), pancreas (RPKM 3.0) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PAK3 in Genome Data Viewer
Location:
Xq23
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (110944397..111227361)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (109392559..109675560)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (110187625..110470589)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:109911493-109912258 Neighboring gene M6PR pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29856 Neighboring gene chordin like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110065211-110065764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:110187999-110188834 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110207796-110208396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:110254037-110254537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29857 Neighboring gene NANOG hESC enhancer GRCh37_chrX:110438658-110439159 Neighboring gene FCF1 pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:110489468-110490667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:110498437-110498970 Neighboring gene glutamate dehydrogenase 1 pseudogene 9 Neighboring gene calpain 6

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Intellectual disability, X-linked 30
MedGen: C0796237 OMIM: 300558 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • DKFZp686E11117

Gene Ontology Provided by GOA

Items 1 - 25 of 30
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables MAP kinase kinase activity PubMed 
enables Rho-dependent protein serine/threonine kinase activity  
enables SH3 domain binding  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables metal ion binding  
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
enables small GTPase binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in axonogenesis  
involved_in cell migration  
involved_in cellular response to organic cyclic compound  
involved_in cellular response to starvation  
involved_in chromatin remodeling  
involved_in dendrite development  
involved_in dendritic spine morphogenesis  
involved_in dendritic spine morphogenesis PubMed 
involved_in ephrin receptor signaling pathway  
involved_in intracellular signal transduction  
involved_in regulation of MAPK cascade  
involved_in regulation of actin cytoskeleton organization  
involved_in regulation of actin filament polymerization PubMed 
involved_in regulation of axonogenesis  
involved_in regulation of postsynapse organization  
involved_in stimulatory C-type lectin receptor signaling pathway  
involved_in synapse organization PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytosol  
located_in glutamatergic synapse  
located_in plasma membrane  
located_in postsynaptic density  

General protein information

Preferred Names
serine/threonine-protein kinase PAK 3
Names
adriamycin resistance-associated
oligophrenin-3
p21 (CDKN1A)-activated kinase 3
p21 protein (Cdc42/Rac)-activated kinase 3
NP_001121638.1
NP_001121639.1
NP_001121640.1
NP_001121644.1
NP_001121645.1
NP_001311254.1
NP_001311255.1
NP_001311256.1
NP_001311257.1
NP_001311258.1
NP_001311259.1
NP_001311260.1
NP_001311261.1
NP_001311262.1
NP_001311263.1
NP_002569.1
XP_005262189.1
XP_005262190.1
XP_006724717.1
XP_006724718.1
XP_011529264.1
XP_011529270.1
XP_011529271.1
XP_011529273.1
XP_016885046.1
XP_016885047.1
XP_016885048.1
XP_016885049.1
XP_016885052.1
XP_047298102.1
XP_047298103.1
XP_047298104.1
XP_047298105.1
XP_047298106.1
XP_054183121.1
XP_054183122.1
XP_054183123.1
XP_054183124.1
XP_054183125.1
XP_054183126.1
XP_054183127.1
XP_054183128.1
XP_054183129.1
XP_054183130.1
XP_054183131.1
XP_054183132.1
XP_054183133.1
XP_054183134.1
XP_054183135.1
XP_054183136.1
XP_054183137.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008288.2 RefSeqGene

    Range
    156907..288077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128166.3NP_001121638.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121638.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AK315284, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000410853.1, ENST00000446737.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  2. NM_001128167.3NP_001121639.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_001121639.1

    Status: REVIEWED

    Source sequence(s)
    AK290504, AL031117, BC117353, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000401982.1, ENST00000425146.5
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  3. NM_001128168.3NP_001121640.1  serine/threonine-protein kinase PAK 3 isoform b

    See identical proteins and their annotated locations for NP_001121640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and contains two alternate in-frame exons compared to variant 1. The encoded isoform (b, also known as ab) is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48151.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  4. NM_001128172.2NP_001121644.1  serine/threonine-protein kinase PAK 3 isoform c

    See identical proteins and their annotated locations for NP_001121644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter 5' UTR and contains an alternate in-frame exon compared to variant 1. It encodes isoform c which is longer than isoform a.
    Source sequence(s)
    AK290504, AL031117, AM943852, BC117353, DB563607
    Consensus CDS
    CCDS48152.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000389172.1, ENST00000417227.5
    Conserved Domains (2) summary
    cd06656
    Location:269565
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69147
    PBD; P21-Rho-binding domain
  5. NM_001128173.3NP_001121645.1  serine/threonine-protein kinase PAK 3 isoform d

    See identical proteins and their annotated locations for NP_001121645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and contains alternate in-frame exon compared to variant 1. It encodes isoform d (also known as b) which is longer than isoform a.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  6. NM_001324325.2NP_001311254.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  7. NM_001324326.2NP_001311255.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  8. NM_001324327.2NP_001311256.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  9. NM_001324328.2NP_001311257.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000262836.4, ENST00000262836.6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  10. NM_001324329.2NP_001311258.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000361080.1, ENST00000372010.5
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  11. NM_001324330.2NP_001311259.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL031117, AL117326, AL356578, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  12. NM_001324331.2NP_001311260.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  13. NM_001324332.2NP_001311261.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  14. NM_001324333.2NP_001311262.1  serine/threonine-protein kinase PAK 3 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS48153.1
    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  15. NM_001324334.2NP_001311263.1  serine/threonine-protein kinase PAK 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain
  16. NM_002578.5NP_002569.1  serine/threonine-protein kinase PAK 3 isoform a

    See identical proteins and their annotated locations for NP_002569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AK290504, AL031117, BC117353, DA022842, DA957724, DB563607
    Consensus CDS
    CCDS14554.1
    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000361077.4, ENST00000372007.10
    Conserved Domains (2) summary
    cd06656
    Location:248544
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69126
    PBD; P21-Rho-binding domain

RNA

  1. NR_136740.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  2. NR_136741.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  3. NR_136742.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  4. NR_136743.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  5. NR_136744.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  6. NR_136745.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  7. NR_136746.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) represents use of an alternate promoter and contains a distinct, shorter 3' end, compared to variant 1. This variant is represented as non-coding because the it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AL357774
  8. NR_136747.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) represents use of an alternate promoter and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL117326, AL357774
  9. NR_136748.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is shorter at the 5' end and contains an alternate exon in the 3' region compared to variant 1.
    Source sequence(s)
    AL031117, AL357774, BC143544

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    110944397..111227361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442148.1XP_047298104.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/TrEMBL
    B2RCU6
  2. XM_047442149.1XP_047298105.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/TrEMBL
    B2RCU6
  3. XM_017029557.2XP_016885046.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (2) summary
    cd06656
    Location:263559
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69141
    PBD; P21-Rho-binding domain
  4. XM_011530968.3XP_011529270.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529270.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  5. XM_011530969.2XP_011529271.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529271.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  6. XM_017029559.2XP_016885048.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  7. XM_017029563.2XP_016885052.1  serine/threonine-protein kinase PAK 3 isoform X7

    UniProtKB/TrEMBL
    B2RCU6
    Related
    ENSP00000428921.1, ENST00000518291.6
    Conserved Domains (2) summary
    cd06656
    Location:284580
    STKc_PAK3; Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3
    pfam00786
    Location:69162
    PBD; P21-Rho-binding domain
  8. XM_047442147.1XP_047298103.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  9. XM_011530962.2XP_011529264.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_011529264.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  10. XM_047442146.1XP_047298102.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  11. XM_005262132.3XP_005262189.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_005262189.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  12. XM_005262133.4XP_005262190.1  serine/threonine-protein kinase PAK 3 isoform X3

    See identical proteins and their annotated locations for XP_005262190.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  13. XM_006724654.3XP_006724717.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724717.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  14. XM_017029558.2XP_016885047.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  15. XM_006724655.3XP_006724718.1  serine/threonine-protein kinase PAK 3 isoform X1

    See identical proteins and their annotated locations for XP_006724718.1

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:283530
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:275530
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
  16. XM_017029560.2XP_016885049.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
    Conserved Domains (3) summary
    smart00220
    Location:268515
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06647
    Location:260515
    STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
    pfam00786
    Location:69124
    PBD; P21-Rho-binding domain
  17. XM_011530971.3XP_011529273.1  serine/threonine-protein kinase PAK 3 isoform X6

    Conserved Domains (2) summary
    pfam00786
    Location:69139
    PBD; P21-Rho-binding domain
    cl21453
    Location:262292
    PKc_like; Protein Kinases, catalytic domain
  18. XM_047442150.1XP_047298106.1  serine/threonine-protein kinase PAK 3 isoform X5

    UniProtKB/TrEMBL
    B2RCU6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    109392559..109675560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327159.1XP_054183134.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/TrEMBL
    B2RCU6
  2. XM_054327160.1XP_054183135.1  serine/threonine-protein kinase PAK 3 isoform X4

    UniProtKB/TrEMBL
    B2RCU6
  3. XM_054327152.1XP_054183127.1  serine/threonine-protein kinase PAK 3 isoform X2

    UniProtKB/Swiss-Prot
    A8K389, B1GX77, B1GX78, B1GX79, O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8
    UniProtKB/TrEMBL
    B2RCU6
  4. XM_054327151.1XP_054183126.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  5. XM_054327150.1XP_054183125.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  6. XM_054327156.1XP_054183131.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  7. XM_054327162.1XP_054183137.1  serine/threonine-protein kinase PAK 3 isoform X7

    UniProtKB/TrEMBL
    B2RCU6
  8. XM_054327158.1XP_054183133.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  9. XM_054327149.1XP_054183124.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  10. XM_054327154.1XP_054183129.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  11. XM_054327146.1XP_054183121.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  12. XM_054327153.1XP_054183128.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  13. XM_054327147.1XP_054183122.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  14. XM_054327155.1XP_054183130.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  15. XM_054327148.1XP_054183123.1  serine/threonine-protein kinase PAK 3 isoform X1

    UniProtKB/TrEMBL
    B2RCU6
  16. XM_054327157.1XP_054183132.1  serine/threonine-protein kinase PAK 3 isoform X3

    UniProtKB/TrEMBL
    B2RCU6
  17. XM_054327161.1XP_054183136.1  serine/threonine-protein kinase PAK 3 isoform X6

External link. Please review our privacy policy.