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    Rab21 RAB21, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299799, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rab21provided by RGD
    Official Full Name
    RAB21, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1303150
    See related
    EnsemblRapid:ENSRNOG00000003923 AllianceGenome:RGD:1303150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in anterograde axonal transport and regulation of axon extension. Located in neuron projection. Is active in synapse. Orthologous to human RAB21 (RAB21, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 200.3), Heart (RPKM 172.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rab21 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52790158..52814943, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (50904050..50928890, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58261985..58286770, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tryptophan hydroxylase 2 Neighboring gene nuclear cap-binding protein subunit 2 pseudogene Neighboring gene TBC1 domain family, member 15 Neighboring gene uncharacterized LOC134479691 Neighboring gene transmembrane protein 19 Neighboring gene THAP domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC94502

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane  
    located_in Golgi membrane  
    located_in axon cytoplasm  
    located_in cleavage furrow  
    located_in cytoplasmic side of early endosome membrane  
    located_in cytoplasmic side of plasma membrane  
    is_active_in early endosome  
    is_active_in endomembrane system  
    located_in endoplasmic reticulum membrane  
    located_in endosome  
    located_in neuron projection PubMed 
    located_in neuron projection  
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 
    located_in trans-Golgi network  
    located_in vesicle membrane  

    General protein information

    Preferred Names
    ras-related protein Rab-21
    NP_001004238.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004238.1NP_001004238.1  ras-related protein Rab-21

      See identical proteins and their annotated locations for NP_001004238.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079323
      UniProtKB/Swiss-Prot
      Q6AXT5
      UniProtKB/TrEMBL
      A6IGK5
      Related
      ENSRNOP00000005258.4, ENSRNOT00000005258.6
      Conserved Domains (1) summary
      cd04123
      Location:18179
      Rab21; Rab GTPase family 21 (Rab21)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      52790158..52814943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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