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RRP36 ribosomal RNA processing 36 [ Homo sapiens (human) ]

Gene ID: 88745, updated on 4-Jan-2025

Summary

Official Symbol
RRP36provided by HGNC
Official Full Name
ribosomal RNA processing 36provided by HGNC
Primary source
HGNC:HGNC:21374
See related
Ensembl:ENSG00000124541 MIM:613475; AllianceGenome:HGNC:21374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf153; dJ20C7.4
Summary
RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]).[supplied by OMIM, Jul 2010]
Expression
Ubiquitous expression in appendix (RPKM 16.4), lymph node (RPKM 15.5) and 25 other tissues See more
Orthologs
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Genomic context

See RRP36 in Genome Data Viewer
Location:
6p21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43021623..43029599)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42850722..42858697)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42989361..42997337)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17212 Neighboring gene Sharpr-MPRA regulatory region 14905 Neighboring gene protein phosphatase 2 regulatory subunit B'delta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42979352-42979852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24584 Neighboring gene male-enhanced antigen 1 Neighboring gene kelch domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42988913-42989644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42989645-42990376 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene Neighboring gene uncharacterized LOC124901318 Neighboring gene cullin 7

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of 90S preribosome  
is_active_in nucleolus  
located_in nucleolus PubMed 
located_in nucleoplasm  
located_in nucleoplasm  

General protein information

Preferred Names
ribosomal RNA processing protein 36 homolog
Names
RNA processing factor
ribosomal RNA processing 36 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329704.2NP_001316633.1  ribosomal RNA processing protein 36 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC011933, BI828671, CN311647
    UniProtKB/TrEMBL
    B2R9K5
  2. NM_033112.4NP_149103.1  ribosomal RNA processing protein 36 homolog isoform 1

    See identical proteins and their annotated locations for NP_149103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC011933, CN311647
    Consensus CDS
    CCDS34453.1
    UniProtKB/Swiss-Prot
    Q96EU6, Q9BRF6, Q9P0C8
    UniProtKB/TrEMBL
    B2R9K5
    Related
    ENSP00000244496.5, ENST00000244496.6
    Conserved Domains (1) summary
    pfam06102
    Location:89245
    RRP36; rRNA biogenesis protein RRP36

RNA

  1. NR_138081.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL136304

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43021623..43029599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42850722..42858697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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