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    Anpep alanyl aminopeptidase, membrane [ Mus musculus (house mouse) ]

    Gene ID: 16790, updated on 4-Jan-2025

    Summary

    Official Symbol
    Anpepprovided by MGI
    Official Full Name
    alanyl aminopeptidase, membraneprovided by MGI
    Primary source
    MGI:MGI:5000466
    See related
    Ensembl:ENSMUSG00000039062 AllianceGenome:MGI:5000466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apn; AP-M; AP-N; Cd13; P150
    Summary
    Enables metallopeptidase activity. Involved in angiotensin maturation. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and sensory organ. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in large intestine adult (RPKM 1188.9), duodenum adult (RPKM 786.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Anpep in Genome Data Viewer
    Location:
    7 D2; 7 45.19 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79471551..79497958, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79821803..79848210, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 1 Neighboring gene mesoderm posterior 2 Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_19292 Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metallopeptidase activity  
    enables metallopeptidase activity PubMed 
    enables peptide binding  
    enables peptide binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in angiotensin maturation PubMed 
    involved_in cell differentiation  
    involved_in peptide catabolic process  
    involved_in peptide catabolic process  
    involved_in protein processing  
    involved_in proteolysis  
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in brush border membrane  
    is_active_in cytoplasm  
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    is_active_in external side of plasma membrane PubMed 
    located_in external side of plasma membrane PubMed 
    located_in extracellular exosome  
    located_in extracellular exosome  
    is_active_in extracellular space  
    located_in extracellular space  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    aminopeptidase N
    Names
    alanyl (membrane) aminopeptidase
    alanyl aminopeptidase
    aminopeptidase M
    aminopeptidase N/CD13
    membrane protein p161
    microsomal aminopeptidase
    NP_032512.2
    XP_036008613.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008486.3NP_032512.2  aminopeptidase N

      See identical proteins and their annotated locations for NP_032512.2

      Status: VALIDATED

      Source sequence(s)
      AI848985, AK143746, AK171427, BY135516
      Consensus CDS
      CCDS21388.1
      UniProtKB/Swiss-Prot
      P97449, Q91YH8, Q99K63
      UniProtKB/TrEMBL
      Q3UP74
      Related
      ENSMUSP00000103015.2, ENSMUST00000107392.8
      Conserved Domains (2) summary
      cd09601
      Location:84545
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:618945
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79471551..79497958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152720.1XP_036008613.1  aminopeptidase N isoform X1

      UniProtKB/Swiss-Prot
      P97449, Q91YH8, Q99K63
      UniProtKB/TrEMBL
      Q3UP74
      Related
      ENSMUSP00000035943.7, ENSMUST00000049004.8
      Conserved Domains (2) summary
      cd09601
      Location:84545
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:618945
      ERAP1_C; ERAP1-like C-terminal domain
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