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    Park7 Parkinson disease (autosomal recessive, early onset) 7 [ Mus musculus (house mouse) ]

    Gene ID: 57320, updated on 4-Jan-2025

    Summary

    Official Symbol
    Park7provided by MGI
    Official Full Name
    Parkinson disease (autosomal recessive, early onset) 7provided by MGI
    Primary source
    MGI:MGI:2135637
    See related
    Ensembl:ENSMUSG00000028964 AllianceGenome:MGI:2135637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj1; DJ-1
    Summary
    Enables oxygen sensor activity and peroxiredoxin activity. Involved in several processes, including detoxification of inorganic compound; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of metabolic process. Acts upstream of or within several processes, including dopamine uptake involved in synaptic transmission; membrane hyperpolarization; and positive regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including cell body; endoplasmic reticulum; and mitochondrion. Is active in synaptic vesicle. Is expressed in central nervous system and retina. Used to study Parkinson's disease 7. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in kidney adult (RPKM 117.4), CNS E11.5 (RPKM 109.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Park7 in Genome Data Viewer
    Location:
    4 E2; 4 81.52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150981590..150994378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150897133..150909921, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700045H11 gene Neighboring gene ribosomal protein S15A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E10293 Neighboring gene ERBB receptor feedback inhibitor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:150271076-150271277 Neighboring gene STARR-seq mESC enhancer starr_12178 Neighboring gene STARR-positive B cell enhancer ABC_E2733 Neighboring gene tumor necrosis factor receptor superfamily, member 9 Neighboring gene predicted gene, 23405

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 56
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables L-dopa decarboxylase activator activity  
    enables L-dopa decarboxylase activator activity  
    enables RNA binding PubMed 
    enables copper ion binding  
    enables copper ion binding  
    enables cupric ion binding  
    enables cupric ion binding  
    enables cuprous ion binding  
    enables cuprous ion binding  
    enables cytokine binding  
    enables cytokine binding  
    enables enzyme binding  
    enables glyoxalase (glycolic acid-forming) activity  
    enables glyoxalase (glycolic acid-forming) activity  
    enables identical protein binding  
    enables kinase binding  
    enables kinase binding  
    enables mRNA binding  
    enables mRNA binding  
    enables mercury ion binding  
    enables mercury ion binding  
    enables nuclear androgen receptor binding  
    enables nuclear androgen receptor binding  
    enables oxidoreductase activity, acting on peroxide as acceptor  
    enables oxidoreductase activity, acting on peroxide as acceptor  
    enables oxygen sensor activity PubMed 
    enables peptidase activity  
    enables peptidase activity  
    enables peptidase inhibitor activity  
    enables peroxiredoxin activity PubMed 
    enables protein binding PubMed 
    enables protein deglycase activity  
    NOT enables protein deglycase activity  
    enables protein deglycase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables signaling receptor activator activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables small protein activating enzyme binding  
    enables small protein activating enzyme binding  
    enables superoxide dismutase copper chaperone activity  
    enables superoxide dismutase copper chaperone activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables tyrosine 3-monooxygenase activator activity  
    enables tyrosine 3-monooxygenase activator activity  
    enables ubiquitin-like protein conjugating enzyme binding  
    enables ubiquitin-like protein conjugating enzyme binding  
    enables ubiquitin-protein transferase inhibitor activity PubMed 
    enables ubiquitin-specific protease binding  
    enables ubiquitin-specific protease binding  
    Items 1 - 25 of 56
    Items 1 - 25 of 153
    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in DNA repair  
    acts_upstream_of_or_within adult locomotory behavior PubMed 
    involved_in androgen receptor signaling pathway  
    involved_in autophagy  
    involved_in cellular detoxification of aldehyde  
    involved_in cellular detoxification of aldehyde  
    involved_in cellular detoxification of methylglyoxal  
    involved_in cellular detoxification of methylglyoxal  
    involved_in cellular response to glyoxal PubMed 
    involved_in cellular response to glyoxal  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to oxidative stress  
    acts_upstream_of_or_within cellular response to reactive oxygen species PubMed 
    involved_in detection of oxidative stress PubMed 
    involved_in detoxification of copper ion PubMed 
    involved_in detoxification of copper ion  
    involved_in detoxification of copper ion  
    involved_in detoxification of hydrogen peroxide  
    involved_in detoxification of hydrogen peroxide  
    involved_in detoxification of mercury ion PubMed 
    involved_in detoxification of mercury ion  
    acts_upstream_of_or_within dopamine uptake involved in synaptic transmission PubMed 
    involved_in glucose homeostasis PubMed 
    involved_in glycolate biosynthetic process  
    involved_in glycolate biosynthetic process PubMed 
    involved_in glycolate biosynthetic process  
    involved_in glyoxal catabolic process  
    involved_in glyoxal metabolic process  
    involved_in glyoxal metabolic process PubMed 
    involved_in glyoxal metabolic process  
    involved_in guanine deglycation  
    involved_in guanine deglycation  
    involved_in guanine deglycation, glyoxal removal  
    involved_in guanine deglycation, glyoxal removal  
    involved_in guanine deglycation, methylglyoxal removal  
    involved_in guanine deglycation, methylglyoxal removal  
    acts_upstream_of_or_within hydrogen peroxide metabolic process PubMed 
    involved_in hydrogen peroxide metabolic process  
    involved_in inflammatory response  
    involved_in insulin secretion PubMed 
    involved_in lactate biosynthetic process  
    involved_in lactate biosynthetic process  
    acts_upstream_of_or_within membrane depolarization PubMed 
    acts_upstream_of_or_within membrane hyperpolarization PubMed 
    involved_in methylglyoxal catabolic process to lactate  
    involved_in methylglyoxal catabolic process to lactate  
    involved_in methylglyoxal metabolic process  
    NOT involved_in methylglyoxal metabolic process  
    involved_in mitochondrion organization PubMed 
    involved_in negative regulation of TRAIL-activated apoptotic signaling pathway  
    involved_in negative regulation of TRAIL-activated apoptotic signaling pathway  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of death-inducing signaling complex assembly  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  
    acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway PubMed 
    acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of protein K48-linked deubiquitination  
    involved_in negative regulation of protein K48-linked deubiquitination  
    involved_in negative regulation of protein acetylation  
    involved_in negative regulation of protein acetylation  
    involved_in negative regulation of protein binding  
    involved_in negative regulation of protein catabolic process PubMed 
    involved_in negative regulation of protein export from nucleus  
    involved_in negative regulation of protein export from nucleus  
    involved_in negative regulation of protein kinase activity  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of protein sumoylation  
    involved_in negative regulation of protein ubiquitination PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in negative regulation of smooth muscle cell migration  
    involved_in negative regulation of ubiquitin-protein transferase activity  
    involved_in negative regulation of ubiquitin-specific protease activity  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in peptidyl-arginine deglycation  
    involved_in peptidyl-cysteine deglycation  
    involved_in peptidyl-lysine deglycation  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of L-dopa biosynthetic process  
    involved_in positive regulation of L-dopa biosynthetic process  
    involved_in positive regulation of L-dopa decarboxylase activity  
    involved_in positive regulation of NAD(P)H oxidase activity PubMed 
    involved_in positive regulation of acute inflammatory response to antigenic stimulus PubMed 
    involved_in positive regulation of androgen receptor activity  
    involved_in positive regulation of dopamine biosynthetic process  
    involved_in positive regulation of dopamine biosynthetic process  
    involved_in positive regulation of fertilization  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone PubMed 
    involved_in positive regulation of mitochondrial electron transport, NADH to ubiquinone  
    involved_in positive regulation of oxidative phosphorylation uncoupler activity PubMed 
    acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of pyrroline-5-carboxylate reductase activity  
    acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of superoxide dismutase activity  
    acts_upstream_of positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription regulatory region DNA binding  
    involved_in positive regulation of tyrosine 3-monooxygenase activity  
    involved_in protein deglycation, glyoxal removal  
    involved_in protein deglycation, methylglyoxal removal  
    involved_in protein deglycosylation  
    involved_in protein repair  
    involved_in protein stabilization PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in proteolysis  
    involved_in regulation of androgen receptor signaling pathway  
    involved_in regulation of androgen receptor signaling pathway  
    involved_in regulation of inflammatory response PubMed 
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of mitochondrial membrane potential  
    involved_in regulation of neuron apoptotic process  
    involved_in regulation of neuron apoptotic process  
    involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in removal of superoxide radicals  
    acts_upstream_of_or_within response to hydrogen peroxide PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide PubMed 
    involved_in response to oxidative stress  
    involved_in response to oxidative stress PubMed 
    involved_in response to oxidative stress  
    involved_in single fertilization  
    acts_upstream_of_or_within synaptic transmission, dopaminergic PubMed 
    Items 1 - 25 of 153
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    located_in PML body  
    located_in PML body  
    located_in axon  
    located_in cell body PubMed 
    located_in chromatin  
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in membrane raft  
    located_in mitochondrial intermembrane space PubMed 
    located_in mitochondrial matrix PubMed 
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in neuron projection PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in sperm head  
    is_active_in synaptic vesicle PubMed 
    is_active_in synaptic vesicle PubMed 
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    Parkinson disease protein 7 homolog
    Names
    RNA-binding protein regulatory subunit
    maillard deglycase
    parkinson disease protein 7 homolog
    parkinsonism-associated deglycase
    protein DJ-1
    protein deglycase DJ-1
    protein/nucleic acid deglycase DJ-1
    NP_065594.2
    XP_036020176.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020569.3NP_065594.2  Parkinson disease protein 7 homolog

      See identical proteins and their annotated locations for NP_065594.2

      Status: VALIDATED

      Source sequence(s)
      AB015652, CA456587, CD776363
      Consensus CDS
      CCDS18975.1
      UniProtKB/Swiss-Prot
      O88306, Q3THB9, Q3U509, Q99LX0
      UniProtKB/TrEMBL
      A2A813
      Related
      ENSMUSP00000030805.8, ENSMUST00000030805.14
      Conserved Domains (1) summary
      TIGR01383
      Location:5184
      not_thiJ; DJ-1 family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      150981590..150994378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164283.1XP_036020176.1  Parkinson disease protein 7 homolog isoform X1

      Conserved Domains (1) summary
      cl00020
      Location:51128
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
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