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TP53INP2 tumor protein p53 inducible nuclear protein 2 [ Homo sapiens (human) ]

Gene ID: 58476, updated on 4-Jan-2025

Summary

Official Symbol
TP53INP2provided by HGNC
Official Full Name
tumor protein p53 inducible nuclear protein 2provided by HGNC
Primary source
HGNC:HGNC:16104
See related
Ensembl:ENSG00000078804 MIM:617549; AllianceGenome:HGNC:16104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1
Summary
The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues See more
Orthologs
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Genomic context

See TP53INP2 in Genome Data Viewer
Location:
20q11.22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34704344..34713436)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36425010..36434099)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33292148..33301240)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33153261-33153762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33170999-33171500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33171501-33172000 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class U Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33264364-33265250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33265251-33266136 Neighboring gene uncharacterized LOC105372599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12843 Neighboring gene Sharpr-MPRA regulatory region 13945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12846 Neighboring gene nuclear receptor coactivator 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ21759, FLJ23500, DKFZp434B2411, DKFZp434O0827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding PubMed 
enables ubiquitin binding  
Component Evidence Code Pubs
located_in PML body  
is_active_in autophagosome  
located_in autophagosome PubMed 
located_in cytoplasmic vesicle  
located_in cytosol PubMed 
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
tumor protein p53-inducible nuclear protein 2
Names
diabetes and obesity-regulated
p53-inducible protein U

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329429.2NP_001316358.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, DB479841
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  2. NM_001329430.2NP_001316359.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, HY150218
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Related
    ENSP00000363942.2, ENST00000374809.6
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  3. NM_001329431.2NP_001316360.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL109824, AY422170, CA310159, HY157843
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family
  4. NM_021202.3NP_067025.1  tumor protein p53-inducible nuclear protein 2

    See identical proteins and their annotated locations for NP_067025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1). All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Related
    ENSP00000363943.3, ENST00000374810.8
    Conserved Domains (1) summary
    pfam14839
    Location:67211
    DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    34704344..34713436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    36425010..36434099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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