U.S. flag

An official website of the United States government

MTF2 metal response element binding transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 22823, updated on 4-Jan-2025

Summary

Official Symbol
MTF2provided by HGNC
Official Full Name
metal response element binding transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:29535
See related
Ensembl:ENSG00000143033 MIM:609882; AllianceGenome:HGNC:29535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M96; PCL2; TDRD19A; dJ976O13.2
Summary
Enables methylated histone binding activity and transcription corepressor binding activity. Predicted to be involved in several processes, including negative regulation of gene expression, epigenetic; segment specification; and stem cell population maintenance. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MTF2 in Genome Data Viewer
Location:
1p22.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93079283..93139076)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (92924870..92984654)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93544840..93604633)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 210, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7481 Neighboring gene RN7SK pseudogene 123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1325 Neighboring gene Sharpr-MPRA regulatory region 13810 Neighboring gene Sharpr-MPRA regulatory region 11191 Neighboring gene MPRA-validated peak321 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1081 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1328 Neighboring gene ribosomal protein L36a pseudogene 11 Neighboring gene coiled-coil domain containing 18

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
enables chromatin binding  
enables metal ion binding  
enables methylated histone binding  
enables methylated histone binding PubMed 
enables protein binding PubMed 
enables transcription corepressor binding PubMed 
Process Evidence Code Pubs
involved_in cellular response to leukemia inhibitory factor  
involved_in epigenetic regulation of gene expression  
involved_in negative regulation of gene expression, epigenetic  
involved_in segment specification  
involved_in stem cell differentiation  
involved_in stem cell population maintenance  
Component Evidence Code Pubs
part_of ESC/E(Z) complex  
located_in cytoplasm PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
metal-response element-binding transcription factor 2
Names
hPCl2
metal regulatory transcription factor 2
metal-response element DNA-binding protein M96
polycomb-like 2
polycomb-like protein 2
putative DNA binding protein
tudor domain containing 19A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164391.2NP_001157863.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate portion of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF072814, AK302776, AL117354, BQ025793, DB173315
    Consensus CDS
    CCDS53341.1
    UniProtKB/TrEMBL
    B4DZG1
    Related
    ENSP00000444962.1, ENST00000545708.5
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  2. NM_001164392.2NP_001157864.1  metal-response element-binding transcription factor 2 isoform b

    See identical proteins and their annotated locations for NP_001157864.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL117354, BC010013, BQ025793, DB173315
    Consensus CDS
    CCDS53340.1
    UniProtKB/TrEMBL
    Q96G26
    Related
    ENSP00000359326.4, ENST00000370303.4
    Conserved Domains (4) summary
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:487534
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:4598
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins
  3. NM_001164393.2NP_001157865.1  metal-response element-binding transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001157865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two coding exons compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK302900, AL117354, BQ025793
    Consensus CDS
    CCDS53341.1
    UniProtKB/TrEMBL
    B4DZG1
    Related
    ENSP00000443295.1, ENST00000540243.5
    Conserved Domains (3) summary
    cd15578
    Location:254
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442489
    Mtf2_C; Polycomb-like MTF2 factor 2
  4. NM_007358.4NP_031384.1  metal-response element-binding transcription factor 2 isoform a

    See identical proteins and their annotated locations for NP_031384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF086908, AJ010014, AL117354, BC001897, BQ025793, CA417978, DB173315
    Consensus CDS
    CCDS742.1
    UniProtKB/Swiss-Prot
    A6NGQ9, A8K2Q3, B1AKT5, B1AKT6, Q96G26, Q9UES9, Q9UP40, Q9Y483
    Related
    ENSP00000359321.4, ENST00000370298.9
    Conserved Domains (4) summary
    cd15578
    Location:104156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544591
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:4598
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    93079283..93139076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    92924870..92984654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.