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Stx16 syntaxin 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362283, updated on 4-Jan-2025

Summary

Official Symbol
Stx16provided by RGD
Official Full Name
syntaxin 16provided by RGD
Primary source
RGD:1309423
See related
EnsemblRapid:ENSRNOG00000005281 AllianceGenome:RGD:1309423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in several processes, including endosomal transport; vesicle docking; and vesicle fusion. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Orthologous to human STX16 (syntaxin 16). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 94.4), Brain (RPKM 88.3) and 9 other tissues See more
Orthologs
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Genomic context

See Stx16 in Genome Data Viewer
Location:
3q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (183271417..183300746)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (162853764..162882489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (172154739..172183699)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486506 Neighboring gene uncharacterized LOC134486507 Neighboring gene aminopeptidase-like 1 Neighboring gene microRNA 296

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNAP receptor activity  
enables SNAP receptor activity  
enables SNARE binding  
enables syntaxin binding  
Process Evidence Code Pubs
involved_in endocytic recycling  
involved_in intracellular protein transport  
involved_in retrograde transport, endosome to Golgi  
involved_in vesicle docking  
involved_in vesicle fusion  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi cisterna  
located_in Golgi membrane  
part_of SNARE complex  
part_of SNARE complex  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
is_active_in endomembrane system  
located_in endoplasmic reticulum  
located_in intracellular membrane-bounded organelle  
located_in membrane  
located_in perinuclear region of cytoplasm  
is_active_in synaptic vesicle membrane PubMed 
is_active_in synaptic vesicle membrane PubMed 
located_in trans-Golgi network  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401893.1NP_001388822.1  syntaxin-16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K528, A0A8I5ZW54
    Related
    ENSRNOP00000062099.3, ENSRNOT00000066279.3
  2. NM_001401894.1NP_001388823.1  syntaxin-16 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AQ84
    Related
    ENSRNOP00000073268.3, ENSRNOT00000088286.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    183271417..183300746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235694.5XP_006235756.1  syntaxin-16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ84, D3Z9R7
    Conserved Domains (2) summary
    cd15845
    Location:230288
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:76190
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
  2. XM_006235695.5XP_006235757.1  syntaxin-16 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZW54
    Conserved Domains (2) summary
    cd15845
    Location:217275
    SNARE_syntaxin16; SNARE motif of syntaxin 16
    cl00143
    Location:63177
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

RNA

  1. XR_005501944.2 RNA Sequence

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