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Ttll4 tubulin tyrosine ligase-like family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 67534, updated on 13-Jan-2025

Summary

Official Symbol
Ttll4provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 4provided by MGI
Primary source
MGI:MGI:1914784
See related
Ensembl:ENSMUSG00000033257 AllianceGenome:MGI:1914784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0173; 4632407P03Rik
Summary
Enables tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Acts upstream of or within regulation of blastocyst development. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in 1-cell stage embryo; 8-cell stage embryo; and blastocyst. Orthologous to human TTLL4 (tubulin tyrosine ligase like 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 16.4), CNS E11.5 (RPKM 10.3) and 27 other tissues See more
Orthologs
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Genomic context

See Ttll4 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74700804..74740991)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74661645..74701832)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 25 Neighboring gene serine/threonine kinase 36 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables metal ion binding  
enables protein binding PubMed 
enables protein-glutamic acid ligase activity PubMed 
enables protein-glutamic acid ligase activity, initiating  
enables tubulin binding  
enables tubulin binding PubMed 
enables tubulin-glutamic acid ligase activity  
enables tubulin-glutamic acid ligase activity PubMed 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium PubMed 
is_active_in ciliary basal body  
located_in ciliary basal body PubMed 
located_in cytoplasm  
located_in microtubule  

General protein information

Preferred Names
tubulin monoglutamylase TTLL4
Names
polyglutamylase
protein monoglutamylase TTLL4
tubulin polyglutamylase TTLL4
tubulin--tyrosine ligase-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014974.2NP_001014974.1  tubulin monoglutamylase TTLL4

    See identical proteins and their annotated locations for NP_001014974.1

    Status: VALIDATED

    Source sequence(s)
    AC152409
    Consensus CDS
    CCDS15053.1
    UniProtKB/Swiss-Prot
    A4Q9E6, Q5U4C4, Q80UG8
    UniProtKB/TrEMBL
    D3YY08
    Related
    ENSMUSP00000037406.9, ENSMUST00000042125.15
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74700804..74740991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496224.3XP_006496287.1  tubulin monoglutamylase TTLL4 isoform X1

    See identical proteins and their annotated locations for XP_006496287.1

    UniProtKB/Swiss-Prot
    A4Q9E6, Q5U4C4, Q80UG8
    UniProtKB/TrEMBL
    D3YY08
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family
  2. XM_006496225.2XP_006496288.1  tubulin monoglutamylase TTLL4 isoform X1

    See identical proteins and their annotated locations for XP_006496288.1

    UniProtKB/Swiss-Prot
    A4Q9E6, Q5U4C4, Q80UG8
    UniProtKB/TrEMBL
    D3YY08
    Related
    ENSMUSP00000109308.2, ENSMUST00000113678.2
    Conserved Domains (1) summary
    pfam03133
    Location:649941
    TTL; Tubulin-tyrosine ligase family
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