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YIF1B Yip1 interacting factor homolog B, membrane trafficking protein [ Homo sapiens (human) ]

Gene ID: 90522, updated on 4-Jan-2025

Summary

Official Symbol
YIF1Bprovided by HGNC
Official Full Name
Yip1 interacting factor homolog B, membrane trafficking proteinprovided by HGNC
Primary source
HGNC:HGNC:30511
See related
Ensembl:ENSG00000167645 MIM:619109; AllianceGenome:HGNC:30511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FinGER8; KABAMAS
Summary
Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in colon (RPKM 13.5), small intestine (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See YIF1B in Genome Data Viewer
Location:
19q13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38303558..38321887, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41105724..41119757, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38794198..38806587, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38746806-38746993 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14A Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38751829-38752766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38752767-38753703 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38753844-38754761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10565 Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38785153-38785654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38788840-38789473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38791160-38791852 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38792217-38792464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38794013-38794750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38794751-38795488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38795489-38796226 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38798184-38798353 Neighboring gene chromosome 19 open reading frame 33 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38810313-38810936 Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10569 Neighboring gene cation channel sperm associated auxiliary subunit gamma Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38833985-38834934 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38842313-38842814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38842815-38843314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38852625-38853566 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38865120-38865750 Neighboring gene proteasome 26S subunit, non-ATPase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • FLJ23477, FLJ50074, MGC39135

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle  
located_in Golgi apparatus PubMed 
is_active_in Golgi membrane  
located_in endoplasmic reticulum PubMed 
is_active_in endoplasmic reticulum membrane  
is_active_in endoplasmic reticulum-Golgi intermediate compartment  
located_in endoplasmic reticulum-Golgi intermediate compartment PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane  

General protein information

Preferred Names
protein YIF1B
Names
YIP1-interacting factor homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039671.3NP_001034760.1  protein YIF1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 5. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 5.
    Source sequence(s)
    AC011479, AK027130, BE877226, BM703847, BX379501, CA487891
    Consensus CDS
    CCDS46066.1
    UniProtKB/TrEMBL
    K7EPQ7
    Related
    ENSP00000329559.7, ENST00000329420.12
    Conserved Domains (1) summary
    pfam03878
    Location:65292
    YIF1; YIF1
  2. NM_001039672.3NP_001034761.1  protein YIF1B isoform 5

    See identical proteins and their annotated locations for NP_001034761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC011479, AK027130, AW630507, BC091477
    Consensus CDS
    CCDS33010.1
    UniProtKB/Swiss-Prot
    H7BXS8, Q5BJH7, Q5JPC2, Q8WY70, Q96C02, Q96IC4
    Related
    ENSP00000343435.5, ENST00000339413.11
    Conserved Domains (1) summary
    pfam03878
    Location:80307
    YIF1; YIF1
  3. NM_001039673.3NP_001034762.1  protein YIF1B isoform 4

    See identical proteins and their annotated locations for NP_001034762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 5. The resulting isoform (4) lacks a 3-aa segment near the N-terminus, compared to isoform 5.
    Source sequence(s)
    AC011479, AK027130, AW630507, BC007644
    UniProtKB/Swiss-Prot
    Q5BJH7
    UniProtKB/TrEMBL
    Q9H5F7
    Conserved Domains (1) summary
    pfam03878
    Location:77304
    YIF1; YIF1
  4. NM_001145461.2NP_001138933.1  protein YIF1B isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 5. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 5.
    Source sequence(s)
    AC011479, AK027130, BM703847, CA487891, CA488303
    UniProtKB/TrEMBL
    K7EPQ7
    Conserved Domains (1) summary
    pfam03878
    Location:58292
    YIF1
  5. NM_001145462.2NP_001138934.1  protein YIF1B isoform 2

    See identical proteins and their annotated locations for NP_001138934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 5. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 5.
    Source sequence(s)
    AC011479, AK027130, BC091477, CF127536
    Consensus CDS
    CCDS12512.1
    UniProtKB/TrEMBL
    K7EPQ7
    Related
    ENSP00000465230.1, ENST00000591784.5
    Conserved Domains (1) summary
    pfam03878
    Location:49276
    YIF1; YIF1
  6. NM_001145463.2NP_001138935.1  protein YIF1B isoform 7

    See identical proteins and their annotated locations for NP_001138935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region and includes an additional exon that results in a frameshift in the 3' coding region, compared to variant 5. The resulting isoform (7) lacks a 3-aa segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 5.
    Source sequence(s)
    AC011479, AK027130, AL833382, AW630507
    Consensus CDS
    CCDS46067.1
    UniProtKB/Swiss-Prot
    Q5BJH7
    UniProtKB/TrEMBL
    Q9H5F7
    Related
    ENSP00000337411.7, ENST00000337679.12
    Conserved Domains (1) summary
    pfam03878
    Location:77280
    YIF1; YIF1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38303558..38321887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439648.1XP_047295604.1  protein YIF1B isoform X1

    UniProtKB/TrEMBL
    K7EPQ7
    Related
    ENSP00000466428.1, ENST00000592694.5
  2. XM_047439647.1XP_047295603.1  protein YIF1B isoform X1

    UniProtKB/TrEMBL
    K7EPQ7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41105724..41119757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322554.1XP_054178529.1  protein YIF1B isoform X1

    UniProtKB/TrEMBL
    K7EPQ7

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