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    Hcls1 hematopoietic cell specific Lyn substrate 1 [ Mus musculus (house mouse) ]

    Gene ID: 15163, updated on 13-Jan-2025

    Summary

    Official Symbol
    Hcls1provided by MGI
    Official Full Name
    hematopoietic cell specific Lyn substrate 1provided by MGI
    Primary source
    MGI:MGI:104568
    See related
    Ensembl:ENSMUSG00000022831 AllianceGenome:MGI:104568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HS1
    Summary
    Enables SH3 domain binding activity. Involved in several processes, including erythrocyte differentiation; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 53.6), thymus adult (RPKM 37.7) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Hcls1 in Genome Data Viewer
    Location:
    16 B3; 16 26.3 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36755345..36783576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36934983..36963214)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ELL associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10903 Neighboring gene STARR-positive B cell enhancer ABC_E5541 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E99 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:36884785-36885086 Neighboring gene golgin B1 Neighboring gene STARR-seq mESC enhancer starr_40776 Neighboring gene STARR-positive B cell enhancer ABC_E8632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:36932162-36932315 Neighboring gene STARR-positive B cell enhancer ABC_E7446 Neighboring gene STARR-positive B cell enhancer ABC_E4169 Neighboring gene STARR-seq mESC enhancer starr_40777 Neighboring gene F-box protein 40 Neighboring gene STARR-seq mESC enhancer starr_40778 Neighboring gene STARR-positive B cell enhancer ABC_E8633 Neighboring gene STARR-positive B cell enhancer ABC_E950 Neighboring gene polymerase (DNA directed), theta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables SH3 domain binding PubMed 
    enables SH3 domain binding PubMed 
    enables actin filament binding  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-containing complex binding PubMed 
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament organization  
    involved_in cell migration  
    involved_in cellular response to cytokine stimulus  
    involved_in erythrocyte differentiation PubMed 
    involved_in granulocyte colony-stimulating factor signaling pathway  
    involved_in granulocyte colony-stimulating factor signaling pathway  
    involved_in negative regulation of leukocyte apoptotic process  
    involved_in negative regulation of leukocyte apoptotic process  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nuclear transport  
    involved_in nuclear transport  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of granulocyte differentiation PubMed 
    involved_in positive regulation of granulocyte differentiation  
    involved_in positive regulation of macrophage differentiation PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of protein import into nucleus  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of actin filament polymerization  
    involved_in regulation of actin filament polymerization  
    involved_in regulation of actin filament polymerization  
    involved_in response to hormone PubMed 
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    colocalizes_with actin filament  
    is_active_in cortical actin cytoskeleton  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in site of polarized growth  
    part_of transcription regulator complex  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    hematopoietic lineage cell-specific protein
    Names
    hematopoietic cell-specific LYN substrate 1
    lckBP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008225.2NP_032251.2  hematopoietic lineage cell-specific protein

      See identical proteins and their annotated locations for NP_032251.2

      Status: VALIDATED

      Source sequence(s)
      AC154763, AK040049, BX519502, CA321698
      Consensus CDS
      CCDS37336.1
      UniProtKB/Swiss-Prot
      P49710, Q922I8
      UniProtKB/TrEMBL
      Q542G0
      Related
      ENSMUSP00000023531.9, ENSMUST00000023531.15
      Conserved Domains (2) summary
      pfam02218
      Location:119154
      HS1_rep; Repeat in HS1/Cortactin
      cl17036
      Location:437485
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36755345..36783576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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