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Aco2 aconitase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79250, updated on 4-Jan-2025

Summary

Official Symbol
Aco2provided by RGD
Official Full Name
aconitase 2provided by RGD
Primary source
RGD:621360
See related
EnsemblRapid:ENSRNOG00000024128 AllianceGenome:RGD:621360
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Predicted to be active in cytosol and mitochondrial matrix. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 5609.7), Muscle (RPKM 4060.0) and 7 other tissues See more
Orthologs
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Genomic context

See Aco2 in Genome Data Viewer
Location:
7q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115265816..115308931)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113385677..113428794)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123102493..123145608)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479944 Neighboring gene PHD finger protein 5A Neighboring gene RNA polymerase III subunit H Neighboring gene small nucleolar RNA SNORA44 Neighboring gene nucleoporin 160 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3 iron, 4 sulfur cluster binding PubMed 
enables 4 iron, 4 sulfur cluster binding  
enables 4 iron, 4 sulfur cluster binding PubMed 
enables 4 iron, 4 sulfur cluster binding  
enables aconitate hydratase activity  
enables aconitate hydratase activity PubMed 
enables aconitate hydratase activity  
enables aconitate hydratase activity  
enables iron ion binding  
enables metal ion binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in cytosol  
is_active_in mitochondrial matrix  
is_active_in mitochondrion  
located_in mitochondrion  
located_in mitochondrion  

General protein information

Preferred Names
aconitate hydratase, mitochondrial
Names
aconitase 2, mitochondrial
citrate hydro-lyase
mitochondrial aconitase (nuclear aco2 gene)
NP_077374.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024398.2NP_077374.2  aconitate hydratase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077374.2

    Status: PROVISIONAL

    Source sequence(s)
    BC061999
    UniProtKB/Swiss-Prot
    Q6P6V3, Q9ER34
    UniProtKB/TrEMBL
    A0A8I5ZLT6, A6HT25
    Related
    ENSRNOP00000111293.1, ENSRNOT00000148951.1
    Conserved Domains (1) summary
    TIGR01340
    Location:45775
    aconitase_mito; aconitate hydratase, mitochondrial

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115265816..115308931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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