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Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 98660, updated on 4-Jan-2025

Summary

Official Symbol
Atp1a2provided by MGI
Official Full Name
ATPase, Na+/K+ transporting, alpha 2 polypeptideprovided by MGI
Primary source
MGI:MGI:88106
See related
Ensembl:ENSMUSG00000007097 AllianceGenome:MGI:88106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpa-3; mKIAA0778
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including locomotory exploration behavior; neurotransmitter uptake; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Part of protein-containing complex. Is active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine 2. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 126.7), frontal lobe adult (RPKM 118.1) and 14 other tissues See more
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Genomic context

See Atp1a2 in Genome Data Viewer
Location:
1 H3; 1 79.6 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172099276..172125631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172271709..172298064, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 17224 Neighboring gene STARR-positive B cell enhancer ABC_E630 Neighboring gene calsequestrin 1 Neighboring gene ATPase, Na+/K+ transporting, alpha 4 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03056 Neighboring gene predicted gene, 57554 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174207398-174207699 Neighboring gene predicted gene, 39704 Neighboring gene STARR-positive B cell enhancer ABC_E5853 Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables ATPase-coupled monoatomic cation transmembrane transporter activity  
enables P-type sodium:potassium-exchanging transporter activity  
enables P-type sodium:potassium-exchanging transporter activity  
enables P-type sodium:potassium-exchanging transporter activity  
enables potassium ion binding  
enables potassium ion binding  
enables protein binding PubMed 
enables protein heterodimerization activity  
enables protein heterodimerization activity  
enables protein-folding chaperone binding  
enables protein-folding chaperone binding  
enables sodium ion binding  
enables sodium ion binding  
enables steroid binding  
enables steroid hormone binding  
enables steroid hormone binding  
Items 1 - 25 of 62
Process Evidence Code Pubs
involved_in ATP metabolic process  
involved_in ATP metabolic process  
acts_upstream_of_or_within L-ascorbic acid metabolic process PubMed 
acts_upstream_of_or_within adult locomotory behavior PubMed 
acts_upstream_of_or_within amygdala development PubMed 
acts_upstream_of_or_within behavioral fear response PubMed 
acts_upstream_of_or_within blood circulation PubMed 
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to steroid hormone stimulus PubMed 
involved_in cellular response to steroid hormone stimulus  
involved_in establishment or maintenance of transmembrane electrochemical gradient  
acts_upstream_of_or_within fear response PubMed 
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
acts_upstream_of_or_within locomotion PubMed 
involved_in locomotory exploration behavior PubMed 
acts_upstream_of_or_within membrane depolarization PubMed 
involved_in monoatomic cation transmembrane transport  
involved_in negative regulation of calcium ion transmembrane transport  
involved_in negative regulation of calcium ion transmembrane transport  
acts_upstream_of_or_within negative regulation of cytosolic calcium ion concentration PubMed 
acts_upstream_of_or_within negative regulation of heart contraction PubMed 
acts_upstream_of_or_within negative regulation of striated muscle contraction PubMed 
acts_upstream_of_or_within neuronal action potential propagation PubMed 
acts_upstream_of_or_within neurotransmitter uptake PubMed 
involved_in neurotransmitter uptake PubMed 
acts_upstream_of_or_within olfactory cortex development PubMed 
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion transmembrane transport  
involved_in potassium ion transport  
involved_in proton transmembrane transport  
involved_in proton transmembrane transport  
involved_in proton transmembrane transport  
acts_upstream_of_or_within regulation of blood pressure PubMed 
involved_in regulation of cardiac muscle cell contraction  
involved_in regulation of cardiac muscle cell contraction  
acts_upstream_of_or_within regulation of muscle contraction PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process PubMed 
acts_upstream_of_or_within regulation of smooth muscle contraction PubMed 
acts_upstream_of_or_within regulation of striated muscle contraction PubMed 
acts_upstream_of_or_within regulation of the force of heart contraction PubMed 
acts_upstream_of_or_within regulation of vasoconstriction PubMed 
acts_upstream_of_or_within regulation of vasoconstriction PubMed 
involved_in response to auditory stimulus PubMed 
involved_in response to glycoside PubMed 
involved_in response to glycoside  
involved_in response to nicotine  
involved_in response to nicotine  
acts_upstream_of_or_within response to potassium ion PubMed 
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transport  
acts_upstream_of_or_within visual learning PubMed 
Items 1 - 25 of 62
Items 1 - 20 of 31
Component Evidence Code Pubs
located_in T-tubule PubMed 
located_in T-tubule  
located_in caveola  
located_in caveola  
is_active_in cell projection  
located_in cell projection PubMed 
is_active_in cell surface PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in dendritic spine  
located_in dendritic spine  
is_active_in endoplasmic reticulum PubMed 
located_in endosome  
located_in endosome  
located_in intercalated disc  
located_in intercalated disc  
located_in membrane  
located_in myelin sheath PubMed 
located_in neuronal cell body PubMed 
located_in organelle membrane  
located_in organelle membrane  
is_active_in plasma membrane  
is_active_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
part_of protein-containing complex PubMed 
located_in sarcolemma PubMed 
located_in sarcolemma  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
Items 1 - 20 of 31

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-2
Names
Na(+)/K(+) ATPase alpha(+) subunit
Na(+)/K(+) ATPase alpha-2 subunit
sodium pump subunit alpha-2
NP_848492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178405.3NP_848492.1  sodium/potassium-transporting ATPase subunit alpha-2

    See identical proteins and their annotated locations for NP_848492.1

    Status: VALIDATED

    Source sequence(s)
    AC087061, AK147331, BY780072
    Consensus CDS
    CCDS35782.1
    UniProtKB/Swiss-Prot
    Q6PIE5, Q80UZ8
    UniProtKB/TrEMBL
    Q3UHK5, Q6ZQ49
    Related
    ENSMUSP00000083077.5, ENSMUST00000085913.11
    Conserved Domains (1) summary
    TIGR01106
    Location:301020
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172099276..172125631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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