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Prim2 DNA primase, p58 subunit [ Mus musculus (house mouse) ]

Gene ID: 19076, updated on 4-Jan-2025

Summary

Official Symbol
Prim2provided by MGI
Official Full Name
DNA primase, p58 subunitprovided by MGI
Primary source
MGI:MGI:97758
See related
Ensembl:ENSMUSG00000026134 AllianceGenome:MGI:97758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and DNA/RNA hybrid binding activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Part of alpha DNA polymerase:primase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in liver E14 (RPKM 13.3), liver E14.5 (RPKM 11.6) and 21 other tissues See more
Orthologs
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Genomic context

See Prim2 in Genome Data Viewer
Location:
1 12.7 cM; 1 B
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33492889..33708867, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33453808..33669808, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PRP3 pre-mRNA processing factor 3 homolog pseudogene Neighboring gene predicted gene, 23453 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:33635449-33635558 Neighboring gene STARR-seq mESC enhancer starr_00539 Neighboring gene STARR-positive B cell enhancer mm9_chr1:33719891-33720191 Neighboring gene RIKEN cDNA 1700001G17 gene Neighboring gene STARR-positive B cell enhancer mm9_chr1:33726515-33726816 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 32229

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding  
enables 4 iron, 4 sulfur cluster binding  
enables DNA binding  
enables DNA/RNA hybrid binding  
enables DNA/RNA hybrid binding  
enables metal ion binding  
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex  
part_of alpha DNA polymerase:primase complex PubMed 
part_of alpha DNA polymerase:primase complex PubMed 
part_of alpha DNA polymerase:primase complex  

General protein information

Preferred Names
DNA primase large subunit
Names
DNA primase 58 kDa subunit
NP_001407370.1
NP_001407371.1
NP_001407372.1
NP_001407373.1
NP_001407374.1
NP_001407375.1
NP_001407376.1
NP_001407378.1
NP_001407379.1
NP_001407380.1
NP_032948.1
XP_006495856.1
XP_006495860.1
XP_011236757.1
XP_030108155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420441.1NP_001407370.1  DNA primase large subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  2. NM_001420442.1NP_001407371.1  DNA primase large subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  3. NM_001420443.1NP_001407372.1  DNA primase large subunit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  4. NM_001420444.1NP_001407373.1  DNA primase large subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  5. NM_001420445.1NP_001407374.1  DNA primase large subunit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  6. NM_001420446.1NP_001407375.1  DNA primase large subunit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    UniProtKB/TrEMBL
    Q3THK0
  7. NM_001420447.1NP_001407376.1  DNA primase large subunit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
  8. NM_001420449.1NP_001407378.1  DNA primase large subunit isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
  9. NM_001420450.1NP_001407379.1  DNA primase large subunit isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
  10. NM_001420451.1NP_001407380.1  DNA primase large subunit isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
  11. NM_008922.3NP_032948.1  DNA primase large subunit isoform 1

    See identical proteins and their annotated locations for NP_032948.1

    Status: VALIDATED

    Source sequence(s)
    AC130712, AC134435
    Consensus CDS
    CCDS14862.1
    UniProtKB/Swiss-Prot
    P33610, Q3U4Z3
    UniProtKB/TrEMBL
    Q3THK0
    Related
    ENSMUSP00000027312.10, ENSMUST00000027312.11
    Conserved Domains (1) summary
    cd07322
    Location:28451
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL

RNA

  1. NR_185176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134435
  2. NR_185177.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC134435

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33492889..33708867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238455.3XP_011236757.1  DNA primase large subunit isoform X2

    Conserved Domains (1) summary
    cd07322
    Location:16236
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
  2. XM_030252295.2XP_030108155.1  DNA primase large subunit isoform X3

    Conserved Domains (1) summary
    cl11970
    Location:28235
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL
  3. XM_006495793.5XP_006495856.1  DNA primase large subunit isoform X1

    Conserved Domains (1) summary
    cl11970
    Location:28234
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL
  4. XM_006495797.4XP_006495860.1  DNA primase large subunit isoform X4

    Conserved Domains (1) summary
    cl11970
    Location:28231
    PriL; Archaeal/eukaryotic core primase: Large subunit, PriL
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