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Nde1 nudE neurodevelopment protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83836, updated on 4-Jan-2025

Summary

Symbol
Nde1provided by RGD
Full Name
nudE neurodevelopment protein 1provided by RGD
Primary source
RGD:620038
See related
EnsemblRapid:ENSRNOG00000058007 AllianceGenome:RGD:620038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nude
Summary
Enables protein domain specific binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; nervous system development; and vesicle transport along microtubule. Predicted to act upstream of or within forebrain development and neuroblast proliferation. Predicted to be located in spindle pole centrosome and synapse. Predicted to be part of kinesin complex. Predicted to be active in centrosome and kinetochore. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 143.9), Heart (RPKM 107.2) and 9 other tissues See more
Orthologs
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Genomic context

See Nde1 in Genome Data Viewer
Location:
10q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (1347010..1391167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (839788..883946, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (860513..904624, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 20 Neighboring gene myosin heavy chain 11 Neighboring gene microRNA 484 Neighboring gene meiosis regulator and mRNA stability factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding  
enables identical protein binding  
enables microtubule binding  
enables microtubule binding  
enables microtubule binding  
enables microtubule binding  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in cell division  
involved_in cell migration  
involved_in centrosome duplication  
involved_in centrosome duplication  
involved_in centrosome duplication  
involved_in centrosome localization  
involved_in cerebral cortex development  
acts_upstream_of_or_within cerebral cortex development  
involved_in cerebral cortex development  
involved_in cerebral cortex development  
involved_in chromosome segregation  
involved_in establishment of chromosome localization  
involved_in establishment of chromosome localization  
involved_in establishment of chromosome localization  
involved_in establishment of mitotic spindle orientation  
involved_in establishment of mitotic spindle orientation  
involved_in establishment of mitotic spindle orientation  
acts_upstream_of_or_within forebrain development  
involved_in microtubule nucleation  
involved_in microtubule nucleation  
acts_upstream_of_or_within microtubule nucleation  
involved_in microtubule organizing center organization  
involved_in mitotic centrosome separation  
involved_in nervous system development  
involved_in neuroblast proliferation  
acts_upstream_of_or_within neuroblast proliferation  
involved_in neuron migration  
involved_in neuron migration  
involved_in vesicle transport along microtubule  
involved_in vesicle transport along microtubule  
acts_upstream_of_or_within vesicle transport along microtubule  
Items 1 - 25 of 31
Component Evidence Code Pubs
is_active_in centrosome  
located_in centrosome  
located_in centrosome  
located_in centrosome  
located_in cleavage furrow  
located_in cytoplasm  
part_of kinesin complex  
is_active_in kinetochore  
located_in kinetochore  
located_in kinetochore  
located_in microtubule  
located_in microtubule organizing center  
located_in spindle  
located_in spindle  
located_in spindle pole centrosome  
located_in spindle pole centrosome  
located_in spindle pole centrosome  
located_in synapse  
located_in synapse  

General protein information

Preferred Names
nuclear distribution protein nudE homolog 1
Names
LIS1-interacting protein NUDE1
nuclear distribution gene E homolog 1
nuclear distribution protein nudE homolog 1-like
nudE nuclear distribution E homolog 1
nudE nuclear distribution gene E homolog 1
rNudE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053347.2NP_445799.1  nuclear distribution protein nudE homolog 1

    See identical proteins and their annotated locations for NP_445799.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q642F3, Q9ES39
    UniProtKB/TrEMBL
    A0A8I6AC74, A6KU37
    Related
    ENSRNOP00000073786.3, ENSRNOT00000086392.3
    Conserved Domains (2) summary
    COG1196
    Location:27186
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04880
    Location:134309
    NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    1347010..1391167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245851.3XP_006245913.1  nuclear distribution protein nudE homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006245913.1

    UniProtKB/Swiss-Prot
    Q642F3, Q9ES39
    UniProtKB/TrEMBL
    A0A8I6AC74, A6KU37
    Conserved Domains (2) summary
    COG1196
    Location:27186
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04880
    Location:134309
    NUDE_C; NUDE protein, C-terminal conserved region
  2. XM_063269977.1XP_063126047.1  nuclear distribution protein nudE homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AC74
  3. XM_006245849.5XP_006245911.1  nuclear distribution protein nudE homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006245911.1

    UniProtKB/TrEMBL
    A0A8I6AC74
    Conserved Domains (3) summary
    PRK14160
    Location:1185
    PRK14160; heat shock protein GrpE; Provisional
    pfam04880
    Location:134309
    NUDE_C; NUDE protein, C-terminal conserved region
    cl03075
    Location:34127
    GrpE; nucleotide exchange factor GrpE
  4. XM_006245850.5XP_006245912.1  nuclear distribution protein nudE homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006245912.1

    UniProtKB/TrEMBL
    A0A8I6AC74
    Conserved Domains (3) summary
    PRK14160
    Location:1185
    PRK14160; heat shock protein GrpE; Provisional
    pfam04880
    Location:134309
    NUDE_C; NUDE protein, C-terminal conserved region
    cl03075
    Location:34127
    GrpE; nucleotide exchange factor GrpE
  5. XM_063269978.1XP_063126048.1  nuclear distribution protein nudE homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AC74

RNA

  1. XR_005489955.2 RNA Sequence

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