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FGF22 fibroblast growth factor 22 [ Homo sapiens (human) ]

Gene ID: 27006, updated on 4-Jan-2025

Summary

Official Symbol
FGF22provided by HGNC
Official Full Name
fibroblast growth factor 22provided by HGNC
Primary source
HGNC:HGNC:3679
See related
Ensembl:ENSG00000070388 MIM:605831; AllianceGenome:HGNC:3679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Biased expression in skin (RPKM 1.5), brain (RPKM 0.4) and 7 other tissues See more
Orthologs
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Genomic context

See FGF22 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (639879..644373)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (594185..598645)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (639879..644373)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13566 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:613339-613520 Neighboring gene RNA polymerase mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:629803-630486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9611 Neighboring gene uncharacterized LOC105372234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13567 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:638495-639220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:644145-645085 Neighboring gene ring finger protein 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:657815-658727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:658728-659641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:678746-679248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:680933-681482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:681483-682031 Neighboring gene follistatin like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding  
enables growth factor activity  
Process Evidence Code Pubs
involved_in cell differentiation PubMed 
involved_in fibroblast growth factor receptor signaling pathway  
involved_in neurogenesis  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of cell population proliferation  
involved_in regulation of cell migration  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in extracellular region  
located_in extracellular space PubMed 

General protein information

Preferred Names
fibroblast growth factor 22
Names
FGF-22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300812.3NP_001287741.1  fibroblast growth factor 22 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004449
    Consensus CDS
    CCDS74241.1
    UniProtKB/TrEMBL
    K7ELB9
    Related
    ENSP00000466004.1, ENST00000586042.6
    Conserved Domains (1) summary
    cl00060
    Location:41106
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. NM_020637.2NP_065688.1  fibroblast growth factor 22 isoform 1 precursor

    See identical proteins and their annotated locations for NP_065688.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC004449
    Consensus CDS
    CCDS12037.1
    UniProtKB/Swiss-Prot
    B2RPH4, Q9HCT0
    UniProtKB/TrEMBL
    A0A7U3JVZ9
    Related
    ENSP00000215530.4, ENST00000215530.7
    Conserved Domains (1) summary
    smart00442
    Location:39167
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    639879..644373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    594185..598645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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