U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ifrd1 interferon-related developmental regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29596, updated on 4-Jan-2025

    Summary

    Symbol
    Ifrd1provided by RGD
    Full Name
    interferon-related developmental regulator 1provided by RGD
    Primary source
    RGD:2867
    See related
    EnsemblRapid:ENSRNOG00000050997 AllianceGenome:RGD:2867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pc4
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in glial cell proliferation and neuroblast proliferation. Acts upstream of or within positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in sarcoplasm. Predicted to be active in nucleus. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 139.6), Liver (RPKM 118.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ifrd1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (62996560..63044996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (57269395..57317833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (60132025..60151354, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene scinderin Neighboring gene leucine-rich single-pass membrane protein 1 Neighboring gene zinc finger protein 277 Neighboring gene uncharacterized LOC120093202 Neighboring gene dedicator of cytokinesis 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93482

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in glial cell proliferation PubMed 
    involved_in muscle cell differentiation  
    acts_upstream_of_or_within muscle cell differentiation  
    involved_in muscle cell differentiation PubMed 
    involved_in negative regulation of axon extension  
    acts_upstream_of_or_within negative regulation of axon extension  
    involved_in negative regulation of collateral sprouting  
    acts_upstream_of_or_within negative regulation of collateral sprouting  
    involved_in neuroblast proliferation PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in skeletal muscle tissue regeneration  
    acts_upstream_of_or_within skeletal muscle tissue regeneration  
    involved_in striated muscle tissue development  
    acts_upstream_of_or_within striated muscle tissue development  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in sarcoplasm  
    located_in sarcoplasm  

    General protein information

    Preferred Names
    interferon-related developmental regulator 1
    Names
    IRPR
    nerve growth factor-inducible protein PC4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019242.2NP_062115.2  interferon-related developmental regulator 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P20695
      UniProtKB/TrEMBL
      M0RDM5, Q5XIV9
      Related
      ENSRNOP00000067730.1, ENSRNOT00000073910.3
      Conserved Domains (2) summary
      pfam04836
      Location:390443
      IFRD_C; Interferon-related protein conserved region
      pfam05004
      Location:40345
      IFRD; Interferon-related developmental regulator (IFRD)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      62996560..63044996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111855.2XP_038967783.1  interferon-related developmental regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACL6
      Related
      ENSRNOP00000089876.1, ENSRNOT00000109955.2
      Conserved Domains (2) summary
      pfam04836
      Location:342395
      IFRD_C; Interferon-related protein conserved region
      pfam05004
      Location:1297
      IFRD; Interferon-related developmental regulator (IFRD)
    2. XM_039111854.2XP_038967782.1  interferon-related developmental regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      P20695
      Conserved Domains (2) summary
      pfam04836
      Location:345398
      IFRD_C; Interferon-related protein conserved region
      pfam05004
      Location:40319
      IFRD; Interferon-related developmental regulator (IFRD)

    RNA

    1. XR_010052052.1 RNA Sequence

    External link. Please review our privacy policy.