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Sec23b SEC23 homolog B, COPII coat complex component [ Mus musculus (house mouse) ]

Gene ID: 27054, updated on 4-Jan-2025

Summary

Official Symbol
Sec23bprovided by MGI
Official Full Name
SEC23 homolog B, COPII coat complex componentprovided by MGI
Primary source
MGI:MGI:1350925
See related
Ensembl:ENSMUSG00000027429 AllianceGenome:MGI:1350925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Cowden syndrome 7 and congenital dyserythropoietic anemia type II. Orthologous to human SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 24.3), large intestine adult (RPKM 23.2) and 28 other tissues See more
Orthologs
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Genomic context

See Sec23b in Genome Data Viewer
Location:
2 G1; 2 71.02 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144398165..144432673)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144556229..144590753)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F Neighboring gene STARR-positive B cell enhancer ABC_E1603 Neighboring gene retinoblastoma binding protein 9, serine hydrolase Neighboring gene predicted gene, 34292 Neighboring gene small integral membrane protein 26 Neighboring gene D-tyrosyl-tRNA deacylase 1 Neighboring gene STARR-seq mESC enhancer starr_05919 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity  
enables protein binding PubMed 
enables zinc ion binding  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding  
involved_in COPII-coated vesicle cargo loading  
involved_in intracellular protein transport  
Component Evidence Code Pubs
part_of COPII vesicle coat  
part_of COPII vesicle coat  
located_in cytosol  
located_in endomembrane system  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum exit site  
located_in endoplasmic reticulum membrane  
located_in perinuclear region of cytoplasm PubMed 

General protein information

Preferred Names
protein transport protein Sec23B
Names
SEC23-related protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252543.2NP_001239472.1  protein transport protein Sec23B isoform 1

    See identical proteins and their annotated locations for NP_001239472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional
  2. NM_001252544.2NP_001239473.1  protein transport protein Sec23B isoform 1

    See identical proteins and their annotated locations for NP_001239473.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional
  3. NM_001252545.2NP_001239474.1  protein transport protein Sec23B isoform 1

    See identical proteins and their annotated locations for NP_001239474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional
  4. NM_001281816.1NP_001268745.1  protein transport protein Sec23B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. This results in an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK029661, CF724836, CK619007, D18665
    UniProtKB/TrEMBL
    Q8CDS4
    Related
    ENSMUST00000128210.2
    Conserved Domains (1) summary
    cl27110
    Location:3613
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
  5. NM_001355379.2NP_001342308.1  protein transport protein Sec23B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional
  6. NM_001355380.2NP_001342309.1  protein transport protein Sec23B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 6. Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional
  7. NM_001412492.1NP_001399421.1  protein transport protein Sec23B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    Q8CDS4
  8. NM_001412493.1NP_001399422.1  protein transport protein Sec23B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    Q8CDS4
  9. NM_001412494.1NP_001399423.1  protein transport protein Sec23B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    Q8CDS4
  10. NM_001412495.1NP_001399424.1  protein transport protein Sec23B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
  11. NM_001412496.1NP_001399425.1  protein transport protein Sec23B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL808119
    UniProtKB/TrEMBL
    Q3TAW4, Q3TIS3
  12. NM_019787.5NP_062761.2  protein transport protein Sec23B isoform 1

    See identical proteins and their annotated locations for NP_062761.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1, 2, 3, 4, 6, and 7 all encode the same isoform (1).
    Source sequence(s)
    AL808119
    Consensus CDS
    CCDS16822.1
    UniProtKB/Swiss-Prot
    A2ANA1, Q3U6B3, Q99K49, Q9D662, Q9QZ68
    UniProtKB/TrEMBL
    Q3TAW4, Q3TYS4, Q3UKB4
    Related
    ENSMUSP00000028916.9, ENSMUST00000028916.15
    Conserved Domains (1) summary
    PLN00162
    Location:12765
    PLN00162; transport protein sec23; Provisional

RNA

  1. NR_178207.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL808119
  2. NR_178208.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL808119

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144398165..144432673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162251.1XP_036018144.1  protein transport protein Sec23B isoform X1

    UniProtKB/TrEMBL
    Q8CDS4
    Conserved Domains (1) summary
    PLN00162
    Location:2655
    PLN00162; transport protein sec23; Provisional
  2. XM_036162249.1XP_036018142.1  protein transport protein Sec23B isoform X1

    UniProtKB/TrEMBL
    Q8CDS4
    Conserved Domains (1) summary
    PLN00162
    Location:2655
    PLN00162; transport protein sec23; Provisional
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