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    Hspa1a heat shock protein family A (Hsp70) member 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24472, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hspa1aprovided by RGD
    Official Full Name
    heat shock protein family A (Hsp70) member 1Aprovided by RGD
    Primary source
    RGD:2840
    See related
    EnsemblRapid:ENSRNOG00000045654 AllianceGenome:RGD:2840
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HSP72; Hspa1; HSP70-2; HSP70.1; HSP70.2; Hsp70-1
    Summary
    Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of release of cytochrome c from mitochondria; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Located in apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Biomarker of graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See Hspa1a in Genome Data Viewer
    Location:
    20p12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3859756..3863800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3855104..3859148)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4877638..4880112, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene uncharacterized LOC102549726 Neighboring gene small nucleolar RNA, C/D box 48

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein disaggregase activity  
    enables ATP-dependent protein folding chaperone  
    enables C3HC4-type RING finger domain binding  
    enables G protein-coupled receptor binding  
    enables NF-kappaB binding PubMed 
    enables death receptor agonist activity  
    enables denatured protein binding  
    enables disordered domain specific binding  
    enables enzyme binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables histone deacetylase binding  
    enables misfolded protein binding  
    enables protease binding PubMed 
    enables protein binding PubMed 
    enables protein folding chaperone  
    enables protein folding chaperone  
    enables receptor ligand activity  
    enables signaling receptor binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    enables transcription regulator inhibitor activity  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    Items 1 - 25 of 27
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    involved_in ATP metabolic process  
    acts_upstream_of_or_within binding of sperm to zona pellucida  
    involved_in cellular heat acclimation  
    involved_in cellular response to heat  
    involved_in cellular response to unfolded protein  
    involved_in chaperone cofactor-dependent protein refolding  
    involved_in chaperone-mediated protein complex assembly  
    involved_in defense response PubMed 
    involved_in lysosomal transport  
    involved_in mRNA catabolic process  
    involved_in mRNA catabolic process  
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in negative regulation of inclusion body assembly  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    NOT involved_in negative regulation of myeloid cell apoptotic process PubMed 
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of release of cytochrome c from mitochondria PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in negative regulation of vasoconstriction PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of RNA splicing  
    involved_in positive regulation of T cell mediated cytotoxicity PubMed 
    involved_in positive regulation of endoribonuclease activity  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in protein folding  
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in protein stabilization  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulation of mitotic spindle assembly  
    involved_in regulation of protein ubiquitination  
    acts_upstream_of_or_within response to heat  
    involved_in response to unfolded protein PubMed 
    involved_in response to unfolded protein  
    involved_in response to unfolded protein  
    involved_in signal transduction  
    Items 1 - 25 of 55
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    part_of COP9 signalosome  
    located_in aggresome  
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    located_in cell body  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in extracellular space  
    located_in inclusion body  
    located_in membrane raft PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    part_of zona pellucida receptor complex  
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    heat shock 70 kDa protein 1A
    Names
    HSP70-1/HSP70-2
    HSP70.1/2
    HSP70.1/HSP70.2
    Heat shock 70 kDa protein 1
    heat shock 70 kDa protein 1/2
    heat shock 70 kDa protein 1A/1B
    heat shock 70 kDa protein 1B
    heat shock 70 kDa protein 2
    heat shock 70kD protein 1A
    heat shock protein 70-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031971.2NP_114177.2  heat shock 70 kDa protein 1A

      See identical proteins and their annotated locations for NP_114177.2

      Status: PROVISIONAL

      Source sequence(s)
      BX883045
      UniProtKB/Swiss-Prot
      P0DMW0, P0DMW1, P42853, Q07439, Q63256
      UniProtKB/TrEMBL
      A0A8L2RAM6, A6KTP2
      Related
      ENSRNOP00000075599.3, ENSRNOT00000081924.4
      Conserved Domains (2) summary
      cd10233
      Location:6381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1641
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3859756..3863800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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