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MED28 mediator complex subunit 28 [ Homo sapiens (human) ]

Gene ID: 80306, updated on 4-Jan-2025

Summary

Official Symbol
MED28provided by HGNC
Official Full Name
mediator complex subunit 28provided by HGNC
Primary source
HGNC:HGNC:24628
See related
Ensembl:ENSG00000118579 MIM:610311; AllianceGenome:HGNC:24628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EG1; magicin; 1500003D12Rik
Summary
Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and somatic stem cell population maintenance. Located in nucleoplasm. Part of core mediator complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues See more
Orthologs
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Genomic context

See MED28 in Genome Data Viewer
Location:
4p15.32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (17614641..17634105)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (17596949..17616365)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17616264..17635728)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21351 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:17584524-17585723 Neighboring gene NACA pseudogene 5 Neighboring gene MED28 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:17615609-17616808 Neighboring gene leucine aminopeptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15312 Neighboring gene family with sequence similarity 184 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:17812049-17812560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:17812561-17813073 Neighboring gene DDB1 and CUL4 associated factor 16 Neighboring gene non-SMC condensin I complex subunit G Neighboring gene ligand dependent nuclear receptor corepressor like

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 28 (MED28) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 28 (MED28) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED28 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • DKFZp434N185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
part_of core mediator complex PubMed 
located_in cortical actin cytoskeleton  
part_of mediator complex  
located_in membrane  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 28
Names
endothelial-derived gene 1
endothelial-derived protein 1
mediator of RNA polymerase II transcription, subunit 28 homolog
merlin and Grb2-interacting cytoskeletal protein
tumor angiogenesis marker EG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025205.5NP_079481.2  mediator of RNA polymerase II transcription subunit 28

    See identical proteins and their annotated locations for NP_079481.2

    Status: VALIDATED

    Source sequence(s)
    AC006160, AF318059
    Consensus CDS
    CCDS33963.1
    UniProtKB/Swiss-Prot
    Q9BZJ5, Q9H204
    UniProtKB/TrEMBL
    H0YAA8
    Related
    ENSP00000237380.6, ENST00000237380.12
    Conserved Domains (1) summary
    pfam11594
    Location:43143
    Med28; Mediator complex subunit 28

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    17614641..17634105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    17596949..17616365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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