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TRAPPC8 trafficking protein particle complex subunit 8 [ Homo sapiens (human) ]

Gene ID: 22878, updated on 4-Jan-2025

Summary

Official Symbol
TRAPPC8provided by HGNC
Official Full Name
trafficking protein particle complex subunit 8provided by HGNC
Primary source
HGNC:HGNC:29169
See related
Ensembl:ENSG00000153339 MIM:614136; AllianceGenome:HGNC:29169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSG1; TRS85; HsT2706; KIAA1012
Summary
Involved in Golgi organization and collagen biosynthetic process. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

See TRAPPC8 in Genome Data Viewer
Location:
18q12.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (31829197..31943128, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (32019706..32133657, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29409160..29523091, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene golgi SNAP receptor complex member 2 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:29318221-29319420 Neighboring gene solute carrier family 25 member 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13207 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29383595-29384386 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29389007-29389784 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29389785-29390562 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29390563-29391340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:29399375-29399875 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29405731-29406276 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406277-29406822 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406823-29407368 Neighboring gene MPRA-validated peak3103 silencer Neighboring gene family with sequence similarity 76 member A pseudogene Neighboring gene MPRA-validated peak3104 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29521986-29522764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13208 Neighboring gene RNA, U6 small nuclear 1050, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29526223-29526906 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29526907-29527590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9387 Neighboring gene epsin 2 pseudogene Neighboring gene phosphogluconate dehydrogenase pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 8 (TRAPPC8) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • KIAA1012, MGC71660

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of TRAPP complex PubMed 
part_of TRAPPIII protein complex  
part_of TRAPPIII protein complex PubMed 
located_in cytoplasm PubMed 
located_in cytosol  

General protein information

Preferred Names
trafficking protein particle complex subunit 8
Names
general sporulation gene 1 homolog
protein TRS85 homolog
trafficking protein particle complex 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014939.5NP_055754.3  trafficking protein particle complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AC009831, AC022960
    Consensus CDS
    CCDS11901.1
    UniProtKB/Swiss-Prot
    A0JP15, B3KME5, Q9H0L2, Q9Y2L5
    UniProtKB/TrEMBL
    J3QQJ5
    Related
    ENSP00000283351.4, ENST00000283351.10
    Conserved Domains (1) summary
    pfam12739
    Location:160604
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    31829197..31943128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025616.3XP_016881105.1  trafficking protein particle complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    J3QQJ5
  2. XM_005258234.4XP_005258291.1  trafficking protein particle complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  3. XM_005258233.4XP_005258290.1  trafficking protein particle complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  4. XM_017025615.2XP_016881104.1  trafficking protein particle complex subunit 8 isoform X3

    UniProtKB/TrEMBL
    J3QQJ5
    Related
    ENSP00000463764.1, ENST00000582539.5
  5. XM_047437353.1XP_047293309.1  trafficking protein particle complex subunit 8 isoform X2

    UniProtKB/TrEMBL
    J3QQJ5
  6. XM_005258235.4XP_005258292.1  trafficking protein particle complex subunit 8 isoform X10

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:14330
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  7. XM_047437356.1XP_047293312.1  trafficking protein particle complex subunit 8 isoform X9

    UniProtKB/TrEMBL
    A8K922
  8. XM_047437355.1XP_047293311.1  trafficking protein particle complex subunit 8 isoform X8

    UniProtKB/TrEMBL
    A8K922
  9. XM_047437354.1XP_047293310.1  trafficking protein particle complex subunit 8 isoform X7

    UniProtKB/TrEMBL
    J3QQJ5
  10. XM_006722420.5XP_006722483.1  trafficking protein particle complex subunit 8 isoform X6

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
  11. XM_047437357.1XP_047293313.1  trafficking protein particle complex subunit 8 isoform X11

    UniProtKB/TrEMBL
    J3KSL8
    Related
    ENSP00000462550.1, ENST00000580104.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    32019706..32133657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318298.1XP_054174273.1  trafficking protein particle complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    J3QQJ5
  2. XM_054318297.1XP_054174272.1  trafficking protein particle complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    J3QQJ5
  3. XM_054318294.1XP_054174269.1  trafficking protein particle complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    J3QQJ5
  4. XM_054318296.1XP_054174271.1  trafficking protein particle complex subunit 8 isoform X3

    UniProtKB/TrEMBL
    J3QQJ5
  5. XM_054318295.1XP_054174270.1  trafficking protein particle complex subunit 8 isoform X2

    UniProtKB/TrEMBL
    J3QQJ5
  6. XM_054318303.1XP_054174278.1  trafficking protein particle complex subunit 8 isoform X10

    UniProtKB/TrEMBL
    J3QQJ5
  7. XM_054318302.1XP_054174277.1  trafficking protein particle complex subunit 8 isoform X9

    UniProtKB/TrEMBL
    A8K922
  8. XM_054318301.1XP_054174276.1  trafficking protein particle complex subunit 8 isoform X8

    UniProtKB/TrEMBL
    A8K922
  9. XM_054318300.1XP_054174275.1  trafficking protein particle complex subunit 8 isoform X7

    UniProtKB/TrEMBL
    J3QQJ5
  10. XM_054318299.1XP_054174274.1  trafficking protein particle complex subunit 8 isoform X6

    UniProtKB/TrEMBL
    J3QQJ5
  11. XM_054318304.1XP_054174279.1  trafficking protein particle complex subunit 8 isoform X11

    UniProtKB/TrEMBL
    J3KSL8
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