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Poln DNA polymerase N [ Mus musculus (house mouse) ]

Gene ID: 272158, updated on 4-Jan-2025

Summary

Official Symbol
Polnprovided by MGI
Official Full Name
DNA polymerase Nprovided by MGI
Primary source
MGI:MGI:2675617
See related
Ensembl:ENSMUSG00000045102 AllianceGenome:MGI:2675617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POL4P
Summary
Predicted to enable DNA-directed DNA polymerase activity and cyclin binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and translesion synthesis. Predicted to act upstream of or within DNA-templated DNA replication. Predicted to be located in nucleoplasm. Is expressed in stomach and testis. Orthologous to human POLN (DNA polymerase nu). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis adult (RPKM 3.7), CNS E11.5 (RPKM 2.7) and 18 other tissues See more
Orthologs
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Genomic context

See Poln in Genome Data Viewer
Location:
5 B2; 5 17.83 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34164523..34326870, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34007179..34169526, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NELL2 interacting cell ontogeny regulator 1 Neighboring gene N-acetyltransferase 8-like Neighboring gene STARR-seq mESC enhancer starr_12835 Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1299 Neighboring gene STARR-seq mESC enhancer starr_12836 Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34530746-34530855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34537815-34537924 Neighboring gene Max dimerization protein 4 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34575558-34575759 Neighboring gene cilia and flagella associated protein 99

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding  
enables DNA-directed DNA polymerase activity  
enables DNA-directed DNA polymerase activity PubMed 
enables cyclin binding  
Process Evidence Code Pubs
involved_in DNA biosynthetic process  
involved_in DNA repair  
acts_upstream_of_or_within DNA-templated DNA replication PubMed 
involved_in double-strand break repair  
involved_in double-strand break repair via homologous recombination  
involved_in interstrand cross-link repair  
involved_in translesion synthesis  
Component Evidence Code Pubs
located_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
DNA polymerase nu
Names
DNA-directed DNA polymerase nu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289803.2NP_001276732.2  DNA polymerase nu isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107709, AC157989
    Consensus CDS
    CCDS80262.1
    UniProtKB/TrEMBL
    A0A0J9YVA9
    Related
    ENSMUSP00000144578.2, ENSMUST00000202409.2
  2. NM_001289804.2NP_001276733.2  DNA polymerase nu isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107709, AC157989
    Consensus CDS
    CCDS80263.1
    UniProtKB/TrEMBL
    A0A0J9YTQ3
    Related
    ENSMUSP00000143793.2, ENSMUST00000202638.4
  3. NM_181857.5NP_862905.2  DNA polymerase nu isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107709, AC157989
    Consensus CDS
    CCDS39067.1
    UniProtKB/Swiss-Prot
    Q3V0L3, Q7TQ07
    UniProtKB/TrEMBL
    A0A0R4J0E3
    Related
    ENSMUSP00000036110.8, ENSMUST00000042954.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34164523..34326870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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