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Uba5 ubiquitin-like modifier activating enzyme 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300968, updated on 4-Jan-2025

Summary

Official Symbol
Uba5provided by RGD
Official Full Name
ubiquitin-like modifier activating enzyme 5provided by RGD
Primary source
RGD:1311702
See related
EnsemblRapid:ENSRNOG00000011027 AllianceGenome:RGD:1311702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ube1dc1
Summary
Predicted to enable UFM1 activating enzyme activity; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including myeloid cell differentiation; protein K69-linked ufmylation; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 122.6), Thymus (RPKM 112.9) and 9 other tissues See more
Orthologs
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Genomic context

See Uba5 in Genome Data Viewer
Location:
8q32
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (113544037..113559711, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104665241..104680915, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (112578607..112594192, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094250 Neighboring gene nephrocystin 3 Neighboring gene acyl-CoA dehydrogenase family, member 11 Neighboring gene atypical chemokine receptor 4 Neighboring gene uncharacterized LOC120094252 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC105565

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables UFM1 activating enzyme activity  
enables UFM1 activating enzyme activity  
enables UFM1 activating enzyme activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables ubiquitin-like modifier activating enzyme activity  
enables zinc ion binding  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in erythrocyte differentiation  
involved_in erythrocyte differentiation  
involved_in megakaryocyte differentiation  
involved_in megakaryocyte differentiation  
involved_in neuromuscular process  
involved_in protein K69-linked ufmylation  
involved_in protein K69-linked ufmylation  
involved_in protein ufmylation  
acts_upstream_of_or_within protein ufmylation  
involved_in protein ufmylation  
involved_in protein ufmylation  
involved_in regulation of intracellular estrogen receptor signaling pathway  
involved_in regulation of intracellular estrogen receptor signaling pathway  
involved_in regulation of type II interferon production  
involved_in regulation of type II interferon production  
acts_upstream_of_or_within response to endoplasmic reticulum stress  
involved_in response to endoplasmic reticulum stress  
involved_in response to endoplasmic reticulum stress  
involved_in reticulophagy  
involved_in reticulophagy  
Component Evidence Code Pubs
located_in Golgi apparatus  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
located_in intracellular membrane-bounded organelle  
located_in nucleus  

General protein information

Preferred Names
ubiquitin-like modifier-activating enzyme 5
Names
UFM1-activating enzyme
ubiquitin-activating enzyme 5
ubiquitin-activating enzyme E1 domain-containing protein 1
ubiquitin-activating enzyme E1-domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009669.2 → NP_001009669.1  ubiquitin-like modifier-activating enzyme 5

    See identical proteins and their annotated locations for NP_001009669.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5M7A4
    UniProtKB/TrEMBL
    A0A8I6GAV1, A6I2L1
    Related
    ENSRNOP00000015240.3, ENSRNOT00000015240.7
    Conserved Domains (2) summary
    cd00757
    Location:50 → 293
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    pfam00899
    Location:51 → 307
    ThiF; ThiF family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    113544037..113559711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595592.3 → XP_017451081.1  ubiquitin-like modifier-activating enzyme 5 isoform X1

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