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Ephb2 Eph receptor B2 [ Mus musculus (house mouse) ]

Gene ID: 13844, updated on 4-Jan-2025

Summary

Official Symbol
Ephb2provided by MGI
Official Full Name
Eph receptor B2provided by MGI
Primary source
MGI:MGI:99611
See related
Ensembl:ENSMUSG00000028664 AllianceGenome:MGI:99611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drt; Erk; Nuk; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5
Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Broad expression in whole brain E14.5 (RPKM 18.7), CNS E14 (RPKM 13.6) and 18 other tissues See more
Orthologs
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Genomic context

See Ephb2 in Genome Data Viewer
Location:
4 D3; 4 69.0 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136374850..136563637, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136647536..136836326, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:136177240-136177540 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1 Neighboring gene STARR-seq mESC enhancer starr_11765 Neighboring gene STARR-seq mESC enhancer starr_11766 Neighboring gene STARR-seq mESC enhancer starr_11767 Neighboring gene VISTA enhancer mm1494 Neighboring gene predicted gene, 52708 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, beta polypeptide Neighboring gene complement component 1, q subcomponent, C chain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 32
Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables amyloid-beta binding PubMed 
enables axon guidance receptor activity PubMed 
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables ephrin receptor activity PubMed 
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables identical protein binding PubMed 
enables insulin receptor activity  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein binding PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase activity PubMed 
enables protein tyrosine kinase collagen receptor activity  
enables protein-containing complex binding PubMed 
enables protein-containing complex binding  
enables signaling receptor activity PubMed 
enables signaling receptor binding PubMed 
enables stem cell factor receptor activity  
enables transmembrane-ephrin receptor activity  
enables transmembrane-ephrin receptor activity PubMed 
enables transmembrane-ephrin receptor activity PubMed 
enables vascular endothelial growth factor receptor activity  
Items 1 - 25 of 32
Items 1 - 25 of 107
Process Evidence Code Pubs
involved_in B cell activation  
involved_in B cell activation  
involved_in Kit signaling pathway  
involved_in angiogenesis PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
involved_in axon guidance  
acts_upstream_of_or_within axon guidance PubMed 
involved_in axon guidance PubMed 
involved_in axonal fasciculation PubMed 
acts_upstream_of axonogenesis PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway  
acts_upstream_of_or_within camera-type eye morphogenesis PubMed 
acts_upstream_of_or_within cell morphogenesis PubMed 
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway PubMed 
involved_in cellular response to amyloid-beta  
involved_in cellular response to lipopolysaccharide  
acts_upstream_of_or_within central nervous system projection neuron axonogenesis PubMed 
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in commissural neuron axon guidance PubMed 
involved_in corpus callosum development PubMed 
involved_in dendritic spine development PubMed 
acts_upstream_of_or_within dendritic spine morphogenesis PubMed 
involved_in dendritic spine morphogenesis PubMed 
involved_in ephrin receptor signaling pathway  
acts_upstream_of_or_within ephrin receptor signaling pathway PubMed 
involved_in ephrin receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in hindbrain tangential cell migration  
involved_in hindbrain tangential cell migration  
involved_in inner ear morphogenesis PubMed 
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
acts_upstream_of_or_within learning PubMed 
involved_in learning or memory PubMed 
involved_in macrophage colony-stimulating factor signaling pathway  
involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
involved_in negative regulation of NMDA glutamate receptor activity PubMed 
involved_in negative regulation of Ras protein signal transduction PubMed 
acts_upstream_of_or_within negative regulation of axonogenesis PubMed 
involved_in negative regulation of cell adhesion  
involved_in negative regulation of cell adhesion  
involved_in negative regulation of cytokine production involved in inflammatory response  
involved_in negative regulation of cytokine production involved in inflammatory response  
acts_upstream_of negative regulation of protein kinase activity PubMed 
involved_in negative regulation of protein phosphorylation PubMed 
involved_in neuron projection retraction PubMed 
acts_upstream_of_or_within optic nerve morphogenesis PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation PubMed 
involved_in peptidyl-tyrosine phosphorylation PubMed 
involved_in peptidyl-tyrosine phosphorylation PubMed 
involved_in phosphorylation PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in positive regulation of B cell proliferation  
involved_in positive regulation of B cell proliferation  
involved_in positive regulation of NMDA glutamate receptor activity PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of dendritic spine morphogenesis  
involved_in positive regulation of dendritic spine morphogenesis  
involved_in positive regulation of gene expression  
involved_in positive regulation of immunoglobulin production  
involved_in positive regulation of immunoglobulin production  
acts_upstream_of_or_within positive regulation of long-term neuronal synaptic plasticity PubMed 
involved_in positive regulation of long-term synaptic potentiation PubMed 
involved_in positive regulation of protein localization to cell surface  
involved_in positive regulation of protein localization to cell surface  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of synapse assembly PubMed 
involved_in positive regulation of synapse assembly PubMed 
involved_in positive regulation of synapse assembly  
involved_in positive regulation of synaptic plasticity PubMed 
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tumor necrosis factor production  
involved_in postsynaptic membrane assembly  
involved_in postsynaptic membrane assembly  
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in regulation of T-helper 17 type immune response  
involved_in regulation of T-helper 17 type immune response  
involved_in regulation of autophagosome assembly  
acts_upstream_of_positive_effect regulation of autophagosome assembly  
acts_upstream_of_or_within regulation of axonogenesis PubMed 
involved_in regulation of behavioral fear response  
involved_in regulation of behavioral fear response  
involved_in regulation of blood coagulation  
involved_in regulation of blood coagulation  
involved_in regulation of body fluid levels PubMed 
involved_in regulation of filopodium assembly  
involved_in regulation of filopodium assembly  
acts_upstream_of_or_within regulation of neuronal synaptic plasticity PubMed 
involved_in regulation of receptor signaling pathway via JAK-STAT  
involved_in regulation of receptor signaling pathway via JAK-STAT  
involved_in regulation of synapse assembly PubMed 
involved_in regulation of synapse assembly PubMed 
involved_in regulation of synapse assembly PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance PubMed 
involved_in roof of mouth development PubMed 
involved_in tight junction assembly  
involved_in tight junction assembly  
involved_in urogenital system development PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
involved_in vesicle-mediated intercellular transport  
involved_in vesicle-mediated intercellular transport  
Items 1 - 25 of 107
Items 1 - 20 of 28
Component Evidence Code Pubs
located_in axon PubMed 
located_in cell surface  
located_in cell surface  
is_active_in dendrite  
located_in dendrite PubMed 
located_in dendrite  
located_in dendritic spine  
located_in dendritic spine  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
located_in neuronal cell body PubMed 
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane PubMed 
located_in postsynapse  
is_active_in postsynaptic membrane PubMed 
is_active_in postsynaptic membrane PubMed 
is_active_in presynaptic membrane PubMed 
is_active_in presynaptic membrane PubMed 
located_in synapse PubMed 
Items 1 - 20 of 28

General protein information

Preferred Names
ephrin type-B receptor 2
Names
neural kinase
nuk receptor tyrosine kinase
tyrosine-protein kinase receptor EPH-3
tyrosine-protein kinase receptor SEK-3
NP_001277682.1
NP_034272.1
XP_006538594.1
XP_006538596.1
XP_006538597.1
XP_030109050.1
XP_030109051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290753.2NP_001277682.1  ephrin type-B receptor 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL671173, BC062924, CJ180821
    Consensus CDS
    CCDS71498.1
    UniProtKB/Swiss-Prot
    P54763
    Related
    ENSMUSP00000058135.8, ENSMUST00000059287.14
    Conserved Domains (5) summary
    cd05065
    Location:617885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam14575
    Location:549617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_010142.4NP_034272.1  ephrin type-B receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_034272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AL671173, BC043088, CJ180821
    Consensus CDS
    CCDS18809.1
    UniProtKB/Swiss-Prot
    A3KG00, A3KG01, A3KG02, A3KG89, A3KG90, P54763, Q62213, Q6GTQ7, Q6P5F1, Q9QVY4
    Related
    ENSMUSP00000101471.3, ENSMUST00000105845.9
    Conserved Domains (5) summary
    cd05065
    Location:616884
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:910980
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437519
    fn3; Fibronectin type III domain
    pfam14575
    Location:548616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136374850..136563637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538534.4XP_006538597.1  ephrin type-B receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05065
    Location:618886
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:912982
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437520
    fn3; Fibronectin type III domain
    pfam14575
    Location:549618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. XM_030253190.2XP_030109050.1  ephrin type-B receptor 2 isoform X3

    Conserved Domains (5) summary
    cd05065
    Location:595863
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:889959
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:1173
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:414497
    fn3; Fibronectin type III domain
    pfam14575
    Location:526595
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_030253191.2XP_030109051.1  ephrin type-B receptor 2 isoform X5

    Conserved Domains (5) summary
    cd05065
    Location:585853
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:879949
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326419
    fn3; Fibronectin type III domain
    pfam14575
    Location:517585
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  4. XM_006538533.5XP_006538596.1  ephrin type-B receptor 2 isoform X4

    Conserved Domains (5) summary
    cd05065
    Location:586854
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:880950
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:326419
    fn3; Fibronectin type III domain
    pfam14575
    Location:517586
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  5. XM_006538531.5XP_006538594.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/Swiss-Prot
    P54763
    Related
    ENSMUSP00000101472.3, ENSMUST00000105846.9
    Conserved Domains (5) summary
    cd05065
    Location:617885
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:911981
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:19196
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:437519
    fn3; Fibronectin type III domain
    pfam14575
    Location:548617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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