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Cd99l2 CD99 antigen-like 2 [ Mus musculus (house mouse) ]

Gene ID: 171486, updated on 4-Jan-2025

Summary

Official Symbol
Cd99l2provided by MGI
Official Full Name
CD99 antigen-like 2provided by MGI
Primary source
MGI:MGI:2177151
See related
Ensembl:ENSMUSG00000035776 AllianceGenome:MGI:2177151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xap89; Mic2l1
Summary
Acts upstream of or within diapedesis; positive regulation of T cell extravasation; and positive regulation of neutrophil extravasation. Located in adherens junction and cell surface. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and skin. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 23.1), whole brain E14.5 (RPKM 17.7) and 25 other tissues See more
Orthologs
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Genomic context

See Cd99l2 in Genome Data Viewer
Location:
X A7.3; X 36.82 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70463666..70536467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71420060..71492866, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7692 Neighboring gene STARR-seq mESC enhancer starr_47322 Neighboring gene X-linked myotubular myopathy gene 1 Neighboring gene myotubularin related protein 1 Neighboring gene STARR-seq mESC enhancer starr_47323 Neighboring gene STARR-seq mESC enhancer starr_47324 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:68808842-68809143 Neighboring gene high mobility group box 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in adherens junction PubMed 
located_in cell surface PubMed 
located_in extracellular region  
located_in plasma membrane  

General protein information

Preferred Names
CD99 antigen-like protein 2
Names
MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1
MIC2 like-1
MIC2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199349.1NP_001186278.1  CD99 antigen-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK080225, BF147574, BY727540
    Consensus CDS
    CCDS57761.1
    UniProtKB/Swiss-Prot
    A2AP77, Q8BIF0, Q8R447
    UniProtKB/TrEMBL
    A2AP74
    Related
    ENSMUSP00000042606.6, ENSMUST00000037391.12
    Conserved Domains (1) summary
    pfam12301
    Location:30215
    CD99L2; CD99 antigen like protein 2
  2. NM_138309.3NP_612182.1  CD99 antigen-like protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_612182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK080225, AY078163, BF147574, BY727540
    Consensus CDS
    CCDS30179.1
    UniProtKB/TrEMBL
    I7HJQ8
    Related
    ENSMUSP00000078944.5, ENSMUST00000080035.11
    Conserved Domains (1) summary
    pfam12301
    Location:30192
    CD99L2; CD99 antigen like protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    70463666..70536467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527887.5XP_006527950.1  CD99 antigen-like protein 2 isoform X2

    UniProtKB/TrEMBL
    I7HJQ8
    Conserved Domains (1) summary
    pfam12301
    Location:30198
    CD99L2; CD99 antigen like protein 2
  2. XM_006527886.5XP_006527949.1  CD99 antigen-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A2AP74
    Conserved Domains (1) summary
    pfam12301
    Location:30221
    CD99L2; CD99 antigen like protein 2
  3. XM_011247540.3XP_011245842.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245842.1

    Conserved Domains (2) summary
    pfam12301
    Location:65144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:2471
    Hydantoinase_B; Hydantoinase B/oxoprolinase
  4. XM_017318407.3XP_017173896.1  CD99 antigen-like protein 2 isoform X4

    Conserved Domains (2) summary
    pfam12301
    Location:65138
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:2471
    Hydantoinase_B; Hydantoinase B/oxoprolinase
  5. XM_011247541.3XP_011245843.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245843.1

    Conserved Domains (2) summary
    pfam12301
    Location:65144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:2471
    Hydantoinase_B; Hydantoinase B/oxoprolinase
  6. XM_011247542.4XP_011245844.1  CD99 antigen-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011245844.1

    Conserved Domains (2) summary
    pfam12301
    Location:65144
    CD99L2; CD99 antigen like protein 2
    cl19816
    Location:2471
    Hydantoinase_B; Hydantoinase B/oxoprolinase
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