U.S. flag

An official website of the United States government

Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 26921, updated on 4-Jan-2025

Summary

Official Symbol
Map4k4provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
Primary source
MGI:MGI:1349394
See related
Ensembl:ENSMUSG00000026074 AllianceGenome:MGI:1349394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGK; Nik; 9430080K19Rik
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Map4k4 in Genome Data Viewer
Location:
1 B; 1 18.53 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39939806..40065470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39900902..40026310)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066B17 gene Neighboring gene STARR-seq mESC enhancer starr_00730 Neighboring gene predicted gene, 35600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39952403-39952658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39953411-39953598 Neighboring gene STARR-seq mESC enhancer starr_00731 Neighboring gene STARR-seq mESC enhancer starr_00732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39991996-39992105 Neighboring gene STARR-positive B cell enhancer ABC_E9463 Neighboring gene VISTA enhancer mm1333 Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene predicted gene, 16894 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 30
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding PubMed 
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables MAP kinase kinase kinase kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables creatine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables microtubule binding  
enables protein binding PubMed 
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in chromatin remodeling  
involved_in intracellular signal transduction  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in negative regulation of neuron projection development  
involved_in negative regulation of neuron projection regeneration  
involved_in neuron projection morphogenesis  
involved_in positive regulation of ARF protein signal transduction PubMed 
involved_in positive regulation of GTPase activity PubMed 
involved_in positive regulation of JNK cascade PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of focal adhesion assembly PubMed 
involved_in positive regulation of focal adhesion disassembly PubMed 
involved_in positive regulation of hippo signaling  
involved_in positive regulation of keratinocyte migration PubMed 
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation  
involved_in regulation of JNK cascade  
involved_in regulation of JNK cascade  
involved_in regulation of MAPK cascade  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in focal adhesion PubMed 
located_in focal adhesion  

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
MEKKK 4
NCK interacting kinase
nck-interacting kinase
NP_001239129.1
NP_001239130.1
NP_001239131.1
NP_032722.2
XP_006496104.1
XP_006496105.1
XP_006496106.1
XP_006496108.1
XP_006496109.1
XP_011236832.1
XP_017176483.1
XP_017176487.1
XP_017176490.1
XP_017176491.1
XP_017176493.1
XP_017176499.1
XP_017176500.1
XP_017176502.1
XP_017176507.1
XP_017176510.1
XP_030110570.1
XP_030110580.1
XP_036021388.1
XP_036021391.1
XP_036021394.1
XP_036021398.1
XP_036021400.1
XP_036021407.1
XP_036021415.1
XP_036021418.1
XP_036021421.1
XP_036021424.1
XP_036021426.1
XP_036021430.1
XP_036021432.1
XP_036021435.1
XP_036021436.1
XP_036021440.1
XP_036021441.1
XP_036021442.1
XP_036021443.1
XP_036021445.1
XP_036021446.1
XP_036021449.1
XP_036021450.1
XP_036021454.1
XP_036021456.1
XP_036021458.1
XP_036021460.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252200.1NP_001239129.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78573.1
    UniProtKB/TrEMBL
    A0A0A6YW53, B7ZNR8
    Related
    ENSMUSP00000141400.2, ENSMUST00000195860.6
    Conserved Domains (3) summary
    smart00036
    Location:9701268
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001252201.1NP_001239130.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001239130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78576.1
    UniProtKB/Swiss-Prot
    P97820
    UniProtKB/TrEMBL
    B2RUE8
    Related
    ENSMUSP00000141862.2, ENSMUST00000193682.6
    Conserved Domains (3) summary
    smart00036
    Location:9031201
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001252202.1NP_001239131.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001239131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78575.1
    UniProtKB/TrEMBL
    B7ZNR9, F8VPL5
    Related
    ENSMUSP00000142056.2, ENSMUST00000195259.6
    Conserved Domains (3) summary
    smart00036
    Location:8901188
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  4. NM_008696.2NP_032722.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_032722.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC132909, AC166238, AK138966, CF531764, U88984
    Consensus CDS
    CCDS35546.1
    UniProtKB/Swiss-Prot
    P97820
    UniProtKB/TrEMBL
    A0A0A6YWR8
    Related
    ENSMUSP00000141665.2, ENSMUST00000192509.6
    Conserved Domains (3) summary
    smart00036
    Location:9161214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39939806..40065470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496041.3XP_006496104.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10651363
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011238530.3XP_011236832.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10011299
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017321001.3XP_017176490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:10621360
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017321010.3XP_017176499.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:9981296
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017320994.3XP_017176483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10641362
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017320998.3XP_017176487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10631361
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  7. XM_036165495.1XP_036021388.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10621360
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017321011.3XP_017176500.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9881286
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  9. XM_036165549.1XP_036021442.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9241222
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  10. XM_036165525.1XP_036021418.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9851283
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  11. XM_036165522.1XP_036021415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9871285
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  12. XM_006496042.3XP_006496105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:10111309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  13. XM_036165537.1XP_036021430.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9471245
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  14. XM_030254710.2XP_030110570.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:10101308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  15. XM_036165539.1XP_036021432.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9461244
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  16. XM_017321004.3XP_017176493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:10091307
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  17. XM_036165542.1XP_036021435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9451243
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  18. XM_036165514.1XP_036021407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:10081306
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  19. XM_036165543.1XP_036021436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9441242
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  20. XM_017321018.3XP_017176507.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9341232
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  21. XM_036165557.1XP_036021450.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:8701168
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  22. XM_017321021.3XP_017176510.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9311229
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  23. XM_036165563.1XP_036021456.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:8671165
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  24. XM_036165547.1XP_036021440.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9331231
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  25. XM_036165561.1XP_036021454.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:8691167
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  26. XM_036165548.1XP_036021441.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:9301228
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  27. XM_017321002.3XP_017176491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10341332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  28. XM_036165505.1XP_036021398.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:10311329
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  29. XM_036165533.1XP_036021426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

    UniProtKB/TrEMBL
    E9PVG7
    Related
    ENSMUSP00000126961.3, ENSMUST00000163854.9
    Conserved Domains (2) summary
    smart00036
    Location:9671265
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  30. XM_036165498.1XP_036021391.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10331331
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  31. XM_036165501.1XP_036021394.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:10321330
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  32. XM_036165507.1XP_036021400.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:10291327
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  33. XM_006496045.3XP_006496108.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:8931191
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  34. XM_006496043.3XP_006496106.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

    UniProtKB/TrEMBL
    A0A0A6YWM8, F8VPL5
    Related
    ENSMUSP00000141613.2, ENSMUST00000195636.6
    Conserved Domains (2) summary
    smart00036
    Location:9541252
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  35. XM_017321013.3XP_017176502.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9801278
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  36. XM_030254720.2XP_030110580.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9771275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  37. XM_036165552.1XP_036021445.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9131211
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  38. XM_036165528.1XP_036021421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9791277
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  39. XM_036165550.1XP_036021443.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9151213
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  40. XM_036165531.1XP_036021424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9761274
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  41. XM_036165565.1XP_036021458.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:8391137
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  42. XM_036165556.1XP_036021449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9001198
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  43. XM_036165567.1XP_036021460.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:8361134
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  44. XM_036165553.1XP_036021446.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:9021200
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain
  45. XM_006496046.3XP_006496109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:8381136
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8289
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001784729.3 RNA Sequence

  2. XR_003955681.2 RNA Sequence

External link. Please review our privacy policy.