Replication interactions
Interaction |
Pubs |
Dynein heavy chain knockdown by siRNA enhances HIV-1 infectivity in TRIMCyp-expressing HeLa cells but not in TRIMCyp-expressing owl monkey cells |
PubMed
|
Knockdown of dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
SiRNA-mediated depletion of the dynein heavy chain leads to a marked relocalization of vRNA and viral structural protein Gag to the cell periphery with late endosomes and a several fold increase in HIV-1 production |
PubMed
|
Rev
|
rev
|
HIV-1 Rev interacting protein, dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr relocalizes DYNC1H1 (DHC) in transfected HeLa cells |
PubMed
|
|
vpr
|
HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) in human HEK293, HeLa and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
|
vpr
|
HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of DYNC1H1 increases the amount of HIV-1 p24 associated with Vpr-associated cytoplasmic virions |
PubMed
|
capsid
|
gag
|
HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of DYNC1H1 increases the amount of HIV-1 p24 associated with cytoplasmic virions |
PubMed
|
|
gag
|
HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells |
PubMed
|
|
gag
|
Dynein heavy chain depletion causes the accumulation of HIV-1 CA cores in infected cells and relocates their subcellular distribution from the vicinity of the nucleus to the cell periphery |
PubMed
|
reverse transcriptase
|
gag-pol
|
Dynein heavy chain (DHC) depletion causes reduced levels of HIV-1 reverse transcribed DNA in infected cells, suggesting RT activity is regulated by DHC |
PubMed
|
Go to the HIV-1, Human Interaction Database