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Trim30d tripartite motif-containing 30D [ Mus musculus (house mouse) ]

Gene ID: 209387, updated on 4-Jan-2025

Summary

Official Symbol
Trim30dprovided by MGI
Official Full Name
tripartite motif-containing 30Dprovided by MGI
Primary source
MGI:MGI:3035181
See related
Ensembl:ENSMUSG00000057596 AllianceGenome:MGI:3035181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim79; TRIM30-3
Summary
Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to be located in P-body. Predicted to be active in cytoplasm. Predicted to colocalize with omegasome. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in bladder adult (RPKM 2.7), large intestine adult (RPKM 2.5) and 23 other tissues See more
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Genomic context

See Trim30d in Genome Data Viewer
Location:
7 E3; 7 55.69 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (104119221..104157062, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104470014..104507853, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 30C Neighboring gene tripartite motif-containing 30A Neighboring gene STARR-positive B cell enhancer ABC_E132 Neighboring gene predicted gene, 25405 Neighboring gene STARR-positive B cell enhancer ABC_E2246 Neighboring gene STARR-seq mESC enhancer starr_19733 Neighboring gene STARR-seq mESC enhancer starr_19734 Neighboring gene STARR-positive B cell enhancer ABC_E6580 Neighboring gene cyclin Y-like 1 pseudogene Neighboring gene tripartite motif-containing 30E, pseudogene 1 Neighboring gene predicted gene 6574

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding  
enables pattern recognition receptor activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein kinase binding  
enables protein kinase binding  
enables protein-macromolecule adaptor activity  
enables transcription coactivator activity  
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
Process Evidence Code Pubs
involved_in activation of innate immune response  
involved_in autophagy  
involved_in innate immune response  
involved_in innate immune response  
involved_in negative regulation of viral entry into host cell  
involved_in positive regulation of DNA-binding transcription factor activity  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in protein K63-linked ubiquitination  
involved_in regulation of gene expression  
involved_in regulation of lipopolysaccharide-mediated signaling pathway  
involved_in regulation of protein localization  
involved_in regulation of protein localization  
involved_in regulation of viral entry into host cell  
involved_in suppression of viral release by host  
Component Evidence Code Pubs
located_in P-body  
is_active_in cytoplasm  
located_in cytoplasm  
colocalizes_with omegasome  

General protein information

Preferred Names
tripartite motif-containing 79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167828.1NP_001161300.1  tripartite motif-containing 79 isoform 2

    See identical proteins and their annotated locations for NP_001161300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon from the 5' coding region, compared to variant 1. This difference results in the use of an in-frame downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK136456, BX525206
    Consensus CDS
    CCDS52347.1
    UniProtKB/TrEMBL
    Q3TNW3
    Related
    ENSMUSP00000065020.7, ENSMUST00000071069.13
    Conserved Domains (1) summary
    cd15822
    Location:140343
    SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)
  2. NM_199146.2NP_954597.2  tripartite motif-containing 79 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122400, AK136456, BX525206
    Consensus CDS
    CCDS40069.1
    UniProtKB/TrEMBL
    E9PWL0, Q6PHA8
    Related
    ENSMUSP00000033211.8, ENSMUST00000033211.14
    Conserved Domains (3) summary
    smart00336
    Location:91132
    BBOX; B-Box-type zinc finger
    cd00162
    Location:1461
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15822
    Location:290493
    SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    104119221..104157062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507548.4XP_006507611.1  tripartite motif-containing 79 isoform X2

    See identical proteins and their annotated locations for XP_006507611.1

    Conserved Domains (2) summary
    cd16591
    Location:1260
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cl00034
    Location:96133
    Bbox_SF; B-box-type zinc finger superfamily
  2. XM_006507546.4XP_006507609.1  tripartite motif-containing 79 isoform X1

    See identical proteins and their annotated locations for XP_006507609.1

    Conserved Domains (2) summary
    cd16591
    Location:1260
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cl00034
    Location:96133
    Bbox_SF; B-box-type zinc finger superfamily
  3. XM_006507549.5XP_006507612.1  tripartite motif-containing 79 isoform X2

    See identical proteins and their annotated locations for XP_006507612.1

    Conserved Domains (2) summary
    cd16591
    Location:1260
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cl00034
    Location:96133
    Bbox_SF; B-box-type zinc finger superfamily
  4. XM_006507547.5XP_006507610.1  tripartite motif-containing 79 isoform X1

    See identical proteins and their annotated locations for XP_006507610.1

    Conserved Domains (2) summary
    cd16591
    Location:1260
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cl00034
    Location:96133
    Bbox_SF; B-box-type zinc finger superfamily
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