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Chmp3 charged multivesicular body protein 3 [ Mus musculus (house mouse) ]

Gene ID: 66700, updated on 4-Jan-2025

Summary

Official Symbol
Chmp3provided by MGI
Official Full Name
charged multivesicular body protein 3provided by MGI
Primary source
MGI:MGI:1913950
See related
Ensembl:ENSMUSG00000053119 AllianceGenome:MGI:1913950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
25.1; NEDF; Vps24; CGI-49; D6Ertd286e; 4921505F14Rik; 9130011K15Rik
Summary
Predicted to enable several functions, including identical protein binding activity; phospholipid binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; early endosome; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in brain; male reproductive gland or organ; metanephros; and neural retinal epithelium. Orthologous to several human genes including CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 24.4), cerebellum adult (RPKM 16.8) and 28 other tissues See more
Orthologs
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Genomic context

See Chmp3 in Genome Data Viewer
Location:
6 C1; 6 32.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71520820..71559593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71543831..71582609)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene ring finger protein 103 Neighboring gene STARR-positive B cell enhancer ABC_E8110 Neighboring gene lysine (K)-specific demethylase 3A Neighboring gene STARR-seq mESC enhancer starr_16264 Neighboring gene STARR-seq mESC enhancer starr_16265 Neighboring gene STARR-positive B cell enhancer ABC_E3659 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71583085-71583314 Neighboring gene STARR-positive B cell enhancer ABC_E9095 Neighboring gene peptidylprolyl isomerase A pseudogene 6_731.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 30
Process Evidence Code Pubs
involved_in autophagosome maturation  
involved_in autophagy  
involved_in endosome to lysosome transport  
involved_in endosome transport via multivesicular body sorting pathway  
involved_in late endosome to lysosome transport  
involved_in late endosome to vacuole transport  
involved_in membrane fission PubMed 
involved_in midbody abscission  
involved_in mitotic metaphase chromosome alignment  
involved_in multivesicular body assembly PubMed 
involved_in multivesicular body sorting pathway  
involved_in multivesicular body-lysosome fusion PubMed 
involved_in nuclear membrane reassembly  
involved_in nucleus organization  
involved_in plasma membrane repair  
involved_in positive regulation of cytokinesis  
involved_in positive regulation of cytokinesis  
involved_in protein polymerization  
involved_in protein transport  
involved_in protein transport  
involved_in regulation of centrosome duplication  
involved_in regulation of early endosome to late endosome transport  
involved_in regulation of endosome size  
involved_in regulation of endosome size  
involved_in regulation of mitotic spindle assembly  
involved_in suppression of viral release by host  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
involved_in vesicle fusion with vacuole PubMed 
involved_in viral budding from plasma membrane  
involved_in viral budding via host ESCRT complex  
Items 1 - 25 of 30
Component Evidence Code Pubs
part_of ESCRT III complex  
part_of ESCRT III complex  
part_of ESCRT III complex  
located_in amphisome membrane  
located_in autophagosome membrane  
located_in cytoplasmic vesicle  
located_in cytosol  
located_in early endosome  
located_in early endosome  
located_in kinetochore  
located_in kinetochore microtubule  
located_in late endosome  
located_in lysosomal membrane  
located_in midbody  
is_active_in multivesicular body  
located_in multivesicular body membrane  
part_of nuclear pore  
located_in plasma membrane  

General protein information

Preferred Names
charged multivesicular body protein 3
Names
chromatin-modifying protein 3
neuroendocrine differentiation factor
vacuolar protein sorting-associated protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355674.1NP_001342603.1  charged multivesicular body protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118686
    Conserved Domains (1) summary
    pfam03357
    Location:1161
    Snf7
  2. NM_001355675.1NP_001342604.1  charged multivesicular body protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118686
    Conserved Domains (1) summary
    pfam03357
    Location:1161
    Snf7
  3. NM_001361405.1NP_001348334.1  charged multivesicular body protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118686, AK014818, BY264596
    Consensus CDS
    CCDS20232.1
    UniProtKB/Swiss-Prot
    Q9CQ10, Q9D2Z2, Q9D7A5
    Related
    ENSMUSP00000068410.3, ENSMUST00000065364.5
    Conserved Domains (1) summary
    pfam03357
    Location:18187
    Snf7
  4. NM_025783.4NP_080059.2  charged multivesicular body protein 3 isoform 1

    See identical proteins and their annotated locations for NP_080059.2

    Status: VALIDATED

    Source sequence(s)
    AI848675, AK083562, BY264596
    Consensus CDS
    CCDS20232.1
    UniProtKB/Swiss-Prot
    Q9CQ10, Q9D2Z2, Q9D7A5
    Related
    ENSMUSP00000109815.4, ENSMUST00000059462.12
    Conserved Domains (1) summary
    pfam03357
    Location:18187
    Snf7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71520820..71559593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506481.5XP_006506544.1  charged multivesicular body protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006506544.1

    Conserved Domains (1) summary
    cl21588
    Location:1121
    Snf7
  2. XM_030255546.2XP_030111406.1  charged multivesicular body protein 3 isoform X1

    Conserved Domains (1) summary
    cl21588
    Location:1121
    Snf7
  3. XM_036152263.1XP_036008156.1  charged multivesicular body protein 3 isoform X1

    Conserved Domains (1) summary
    cl21588
    Location:1121
    Snf7
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