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Acsl1 acyl-CoA synthetase long-chain family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25288, updated on 4-Jan-2025

Summary

Official Symbol
Acsl1provided by RGD
Official Full Name
acyl-CoA synthetase long-chain family member 1provided by RGD
Primary source
RGD:2015
See related
EnsemblRapid:ENSRNOG00000010633 AllianceGenome:RGD:2015
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ACS; Acas; COAA; Facl2
Summary
Enables arachidonate-CoA ligase activity; oleoyl-CoA ligase activity; and phytanate-CoA ligase activity. Involved in several processes, including fatty acid metabolic process; lipid biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in mitochondrial outer membrane and peroxisomal membrane. Biomarker of obesity. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 2227.9), Heart (RPKM 1039.3) and 6 other tissues See more
Orthologs
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Genomic context

See Acsl1 in Genome Data Viewer
Location:
16q11
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52487870..52554110, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45755246..45821541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48937456..49003898, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene uncharacterized LOC108348397 Neighboring gene uncharacterized LOC120097416 Neighboring gene small nucleolar RNA SNORA26

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 26
Process Evidence Code Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway  
involved_in fatty acid metabolic process PubMed 
involved_in fatty acid transport PubMed 
involved_in fatty acid transport  
involved_in lipid biosynthetic process  
involved_in lipid biosynthetic process  
involved_in long-chain fatty acid import into cell PubMed 
involved_in long-chain fatty acid import into cell  
involved_in long-chain fatty acid metabolic process  
involved_in long-chain fatty acid metabolic process PubMed 
involved_in long-chain fatty acid metabolic process  
involved_in long-chain fatty acid metabolic process  
involved_in long-chain fatty acid metabolic process  
involved_in long-chain fatty-acyl-CoA biosynthetic process  
involved_in long-chain fatty-acyl-CoA biosynthetic process PubMed 
involved_in positive regulation of cold-induced thermogenesis  
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane PubMed 
involved_in response to nutrient PubMed 
involved_in response to oleic acid PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in triglyceride biosynthetic process PubMed 
involved_in very long-chain fatty acid metabolic process  
involved_in very long-chain fatty acid metabolic process PubMed 
involved_in xenobiotic catabolic process PubMed 
Items 1 - 25 of 26
Component Evidence Code Pubs
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
is_active_in membrane  
located_in mitochondrial outer membrane PubMed 
located_in mitochondrial outer membrane  
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in peroxisomal membrane PubMed 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase 1
Names
Acyl CoA synthetase, long chain
LACS 1
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 2
long-chain acyl-CoA synthetase 1
long-chain-fatty-acid--CoA ligase, liver isozyme
phytanate--CoA ligase
NP_036952.1
XP_006253184.1
XP_006253185.1
XP_006253186.1
XP_006253187.1
XP_006253188.1
XP_006253189.1
XP_038950128.1
XP_063131127.1
XP_063131128.1
XP_063131129.1
XP_063131130.1
XP_063131132.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012820.2NP_036952.1  long-chain-fatty-acid--CoA ligase 1

    See identical proteins and their annotated locations for NP_036952.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Related
    ENSRNOP00000014235.1, ENSRNOT00000014235.5
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    52487870..52554110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094200.2XP_038950128.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/TrEMBL
    A6JPN4
    Related
    ENSRNOP00000108734.1, ENSRNOT00000164041.1
    Conserved Domains (1) summary
    cd05927
    Location:117661
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  2. XM_006253123.3XP_006253185.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253185.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. XM_063275058.1XP_063131128.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/TrEMBL
    A6JPN4
  4. XM_006253122.3XP_006253184.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253184.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  5. XM_006253125.5XP_006253187.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253187.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  6. XM_063275060.1XP_063131130.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/TrEMBL
    A6JPN4
  7. XM_063275062.1XP_063131132.1  long-chain-fatty-acid--CoA ligase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8L2R6L8, A6JPN4
    Related
    ENSRNOP00000072677.2, ENSRNOT00000089501.3
  8. XM_006253126.4XP_006253188.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253188.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  9. XM_006253127.1XP_006253189.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253189.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  10. XM_006253124.4XP_006253186.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006253186.1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
    Conserved Domains (1) summary
    cd05927
    Location:117695
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  11. XM_063275059.1XP_063131129.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    UniProtKB/TrEMBL
    A6JPN4
  12. XM_063275057.1XP_063131127.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

    UniProtKB/Swiss-Prot
    P18163
    UniProtKB/TrEMBL
    A6JPN3, A6JPN4
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