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Cxcr4 C-X-C motif chemokine receptor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60628, updated on 4-Jan-2025

Summary

Official Symbol
Cxcr4provided by RGD
Official Full Name
C-X-C motif chemokine receptor 4provided by RGD
Primary source
RGD:620465
See related
EnsemblRapid:ENSRNOG00000003866 AllianceGenome:RGD:620465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables small molecule binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Located in endosome. Used to study pulmonary hypertension and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome 1; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 542.4), Lung (RPKM 351.9) and 8 other tissues See more
Orthologs
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Genomic context

See Cxcr4 in Genome Data Viewer
Location:
13q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (42630383..42634288, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (40077976..40081883, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (45314952..45318856, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC120096242 Neighboring gene uncharacterized LOC134481488 Neighboring gene uncharacterized LOC102548838

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC108696

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C-C chemokine binding  
enables C-C chemokine binding  
enables C-C chemokine receptor activity  
enables C-C chemokine receptor activity PubMed 
enables C-X-C chemokine receptor activity PubMed 
enables C-X-C motif chemokine 12 receptor activity  
enables C-X-C motif chemokine 12 receptor activity  
enables actin binding  
enables myosin light chain binding  
enables small molecule binding PubMed 
enables ubiquitin binding  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 72
Process Evidence Code Pubs
acts_upstream_of_or_within CXCL12-activated CXCR4 signaling pathway  
involved_in CXCL12-activated CXCR4 signaling pathway  
involved_in CXCL12-activated CXCR4 signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within T cell proliferation  
acts_upstream_of_or_within ameboidal-type cell migration  
acts_upstream_of_or_within aorta development  
acts_upstream_of_or_within blood vessel endothelial cell migration  
involved_in brain development  
acts_upstream_of_or_within brain development  
acts_upstream_of_or_within branching involved in blood vessel morphogenesis  
involved_in calcium-mediated signaling  
acts_upstream_of_or_within calcium-mediated signaling  
involved_in cardiac muscle contraction PubMed 
involved_in cell chemotaxis  
involved_in cell migration PubMed 
acts_upstream_of_or_within cellular response to cytokine stimulus  
involved_in cellular response to cytokine stimulus  
involved_in cellular response to cytokine stimulus  
involved_in cellular response to xenobiotic stimulus PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
involved_in detection of temperature stimulus involved in sensory perception of pain PubMed 
involved_in endothelial cell differentiation PubMed 
involved_in endothelial tube morphogenesis PubMed 
involved_in epithelial cell development PubMed 
involved_in generation of neurons  
acts_upstream_of_or_within germ cell development  
acts_upstream_of_or_within germ cell migration  
acts_upstream_of_or_within hematopoietic stem cell migration  
involved_in immune response  
acts_upstream_of_or_within kidney development  
acts_upstream_of_or_within motor neuron axon guidance  
involved_in myelin maintenance  
involved_in neural precursor cell proliferation  
involved_in neurogenesis  
involved_in neurogenesis PubMed 
involved_in neuron migration PubMed 
involved_in neuron migration PubMed 
acts_upstream_of_or_within neuron migration  
involved_in neuron recognition PubMed 
involved_in osteoclast differentiation PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
acts_upstream_of_or_within positive regulation of calcium ion import  
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell migration  
involved_in positive regulation of chemotaxis PubMed 
involved_in positive regulation of cold-induced thermogenesis  
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of dendrite extension PubMed 
involved_in positive regulation of macrophage migration inhibitory factor signaling pathway  
involved_in positive regulation of mesenchymal stem cell migration PubMed 
involved_in positive regulation of neurogenesis PubMed 
involved_in positive regulation of oligodendrocyte differentiation  
acts_upstream_of_or_within positive regulation of protein phosphorylation  
involved_in positive regulation of vascular wound healing PubMed 
involved_in positive regulation of vasculature development  
involved_in regulation of calcium ion transport PubMed 
involved_in regulation of cell adhesion  
acts_upstream_of_or_within regulation of cell migration  
involved_in regulation of chemotaxis PubMed 
involved_in regulation of chemotaxis  
acts_upstream_of_or_within regulation of neuron migration  
involved_in regulation of programmed cell death PubMed 
involved_in regulation of viral process PubMed 
involved_in response to activity PubMed 
involved_in response to hypoxia  
involved_in response to organic cyclic compound PubMed 
involved_in response to tacrolimus PubMed 
involved_in response to ultrasound PubMed 
involved_in telencephalon cell migration PubMed 
acts_upstream_of_or_within ventricular septum development  
Items 1 - 25 of 72
Component Evidence Code Pubs
located_in cell leading edge  
located_in cell surface  
located_in cell-cell junction  
located_in cytoplasmic vesicle  
located_in early endosome  
located_in early endosome  
located_in endosome PubMed 
is_active_in external side of plasma membrane  
located_in external side of plasma membrane  
located_in growth cone  
located_in late endosome  
located_in late endosome  
located_in lysosome  
located_in lysosome  
located_in plasma membrane  
part_of protein-containing complex  

General protein information

Preferred Names
C-X-C chemokine receptor type 4
Names
CXC chemokine receptor
CXC-R4
CXCR-4
LESTR
SDF-1 receptor
chemokine (C-X-C motif) receptor 4
chemokine receptor (LCR1)
fusin
leukocyte-derived seven transmembrane domain receptor
stromal cell-derived factor 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022205.3NP_071541.2  C-X-C chemokine receptor type 4

    See identical proteins and their annotated locations for NP_071541.2

    Status: VALIDATED

    Source sequence(s)
    BC089804, CO557829
    UniProtKB/Swiss-Prot
    F1LPN8, O08565, Q8VD47
    UniProtKB/TrEMBL
    A9CMB9
    Related
    ENSRNOP00000005143.5, ENSRNOT00000005143.8
    Conserved Domains (2) summary
    pfam12109
    Location:335
    CXCR4_N; CXCR4 Chemokine receptor N terminal
    cd15179
    Location:36310
    7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    42630383..42634288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272571.1XP_063128641.1  C-X-C chemokine receptor type 4 isoform X1

    UniProtKB/TrEMBL
    A9CMB9
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