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Prl7a1 prolactin family 7, subfamily a, member 1 [ Mus musculus (house mouse) ]

Gene ID: 19113, updated on 4-Jan-2025

Summary

Official Symbol
Prl7a1provided by MGI
Official Full Name
prolactin family 7, subfamily a, member 1provided by MGI
Primary source
MGI:MGI:1206572
See related
Ensembl:ENSMUSG00000006488 AllianceGenome:MGI:1206572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLP-E; PLP-G; Prlpe; Prlpg
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component; labyrinthine zone; and placenta. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward placenta adult (RPKM 658.2) See more
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Genomic context

See Prl7a1 in Genome Data Viewer
Location:
13 A3.1; 13 12.56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27817347..27826476, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27633364..27642493, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily a, member 1 Neighboring gene STARR-seq mESC enhancer starr_34016 Neighboring gene prolactin family 7, subfamily b, member 1 Neighboring gene prolactin family 7, subfamily a, member 2 Neighboring gene prolactin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity  
enables hormone activity  
enables prolactin receptor binding  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway  
involved_in female pregnancy  
involved_in mammary gland development  
involved_in positive regulation of lactation  
involved_in positive regulation of receptor signaling pathway via JAK-STAT  
involved_in response to nutrient levels  
involved_in signal transduction  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  

General protein information

Preferred Names
prolactin-7A1
Names
PRL-like protein E
PRL-like protein G
placental prolactin-like protein E
placental prolactin-like protein G
prolactin-like protein E
prolactin-like protein G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164058.1NP_001157530.1  prolactin-7A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF011381, AK146050, BC051671
    Consensus CDS
    CCDS49224.1
    UniProtKB/Swiss-Prot
    O35334, O54830, Q80X21
    Related
    ENSMUSP00000093614.4, ENSMUST00000095924.11
    Conserved Domains (1) summary
    cd10288
    Location:31255
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
  2. NM_008930.2NP_032956.1  prolactin-7A1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_032956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks one internal residue, compared to isoform 1.
    Source sequence(s)
    AF011381, BB611867, BC051671
    Consensus CDS
    CCDS26403.1
    UniProtKB/Swiss-Prot
    O54830
    Related
    ENSMUSP00000006659.7, ENSMUST00000006659.8
    Conserved Domains (1) summary
    cd10288
    Location:30254
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27817347..27826476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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