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Mbd2 methyl-CpG binding domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17191, updated on 5-Jan-2025

Summary

Official Symbol
Mbd2provided by MGI
Official Full Name
methyl-CpG binding domain protein 2provided by MGI
Primary source
MGI:MGI:1333813
See related
Ensembl:ENSMUSG00000024513 AllianceGenome:MGI:1333813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBD2a
Summary
Enables chromatin binding activity; identical protein binding activity; and nucleic acid binding activity. Acts upstream of or within several processes, including maternal behavior; negative regulation of transcription by RNA polymerase II; and positive regulation of Wnt signaling pathway. Located in cytoplasm; heterochromatin; and nucleus. Part of histone deacetylase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb ectoderm; and pancreas. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 26.7), liver E14 (RPKM 24.5) and 28 other tissues See more
Orthologs
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Genomic context

See Mbd2 in Genome Data Viewer
Location:
18 E2; 18 44.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70701298..70761769)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (70568225..70629134)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930503L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E11002 Neighboring gene StAR related lipid transfer domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E1519 Neighboring gene polymerase (DNA directed), iota Neighboring gene microRNA 6357 Neighboring gene STARR-positive B cell enhancer ABC_E8725 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:70722848-70723181 Neighboring gene STARR-seq mESC enhancer starr_44965 Neighboring gene predicted gene, 31671 Neighboring gene STARR-seq mESC enhancer starr_44968 Neighboring gene STARR-positive B cell enhancer ABC_E968 Neighboring gene predicted gene, 41772 Neighboring gene 60S ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding  
enables C2H2 zinc finger domain binding  
enables DNA binding PubMed 
enables chromatin binding PubMed 
enables chromatin binding  
enables identical protein binding PubMed 
enables mRNA binding PubMed 
enables methyl-CpG binding  
enables methyl-CpG binding PubMed 
enables methyl-CpG binding  
enables molecular adaptor activity  
enables protein binding PubMed 
enables protein domain specific binding  
enables siRNA binding PubMed 
Process Evidence Code Pubs
involved_in DNA methylation-dependent constitutive heterochromatin formation  
involved_in DNA methylation-dependent constitutive heterochromatin formation  
involved_in DNA methylation-dependent constitutive heterochromatin formation  
acts_upstream_of Wnt signaling pathway PubMed 
involved_in cellular response to organic cyclic compound  
involved_in chromatin remodeling  
involved_in chromatin remodeling  
involved_in embryonic organ development  
acts_upstream_of_or_within maternal behavior PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in positive regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway PubMed 
acts_upstream_of_or_within protein-containing complex assembly PubMed 
acts_upstream_of_or_within regulation of cell population proliferation PubMed 
involved_in response to estradiol  
involved_in response to mechanical stimulus  
involved_in response to nutrient levels  
involved_in ventricular cardiac muscle tissue development  
Component Evidence Code Pubs
part_of NuRD complex  
part_of NuRD complex  
part_of NuRD complex PubMed 
located_in chromatin PubMed 
located_in chromatin  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in heterochromatin PubMed 
part_of histone deacetylase complex PubMed 
NOT located_in nucleolus PubMed 
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
methyl-CpG-binding domain protein 2
Names
methyl-CpG-binding protein MBD2
testis-specific methyl-CpG binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311071.1NP_001298000.1  methyl-CpG-binding domain protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 3' coding region and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC134831, AF072245, BE953207, CX239662
    Consensus CDS
    CCDS79661.1
    UniProtKB/Swiss-Prot
    Q9Z2E1
    Related
    ENSMUSP00000110596.4, ENSMUST00000114946.4
    Conserved Domains (1) summary
    cd01396
    Location:154217
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
  2. NM_010773.2NP_034903.2  methyl-CpG-binding domain protein 2 isoform 1

    See identical proteins and their annotated locations for NP_034903.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF072243, AK147008, BU757659, CX239662
    Consensus CDS
    CCDS29335.1
    UniProtKB/Swiss-Prot
    E9QMV9, Q811D9, Q9Z2D9, Q9Z2E1
    Related
    ENSMUSP00000073701.5, ENSMUST00000074058.11
    Conserved Domains (3) summary
    cd01396
    Location:154217
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam14048
    Location:300390
    MBD_C; C-terminal domain of methyl-CpG binding protein 2 and 3
    pfam16564
    Location:230295
    MBDa; p55-binding region of Methyl-CpG-binding domain proteins MBD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    70701298..70761769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161008.1XP_036016901.1  methyl-CpG-binding domain protein 2 isoform X1

  2. XM_006525711.5XP_006525774.1  methyl-CpG-binding domain protein 2 isoform X2

    Conserved Domains (1) summary
    cd01396
    Location:154217
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...

RNA

  1. XR_001782347.3 RNA Sequence

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