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Cdk6 cyclin-dependent kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114483, updated on 4-Jan-2025

Summary

Official Symbol
Cdk6provided by RGD
Official Full Name
cyclin-dependent kinase 6provided by RGD
Primary source
RGD:621121
See related
EnsemblRapid:ENSRNOG00000009258 AllianceGenome:RGD:621121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cyclin binding activity. Involved in DNA damage response. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D1-CDK6 complex; cyclin D2-CDK6 complex; and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm and nucleus. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 105.7), Kidney (RPKM 87.0) and 9 other tissues See more
Orthologs
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Genomic context

See Cdk6 in Genome Data Viewer
Location:
4q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31592384..31784732, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30637650..30829688, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27781728..27969653, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700109H08 gene like Neighboring gene RNA binding motif protein 48 Neighboring gene family with sequence similarity 133, member B Neighboring gene uncharacterized LOC134486561 Neighboring gene uncharacterized LOC108350668 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding  
enables FBXO family protein binding  
enables cyclin binding  
enables cyclin binding PubMed 
enables cyclin binding  
enables cyclin-dependent protein serine/threonine kinase activity  
enables cyclin-dependent protein serine/threonine kinase activity  
enables kinase activity  
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in DNA damage response PubMed 
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle  
acts_upstream_of_or_within Notch signaling pathway  
acts_upstream_of_or_within T cell differentiation in thymus  
involved_in cell dedifferentiation  
involved_in gliogenesis  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
acts_upstream_of_or_within hematopoietic stem cell differentiation  
involved_in hemopoiesis  
involved_in negative regulation of cell cycle  
involved_in negative regulation of cellular senescence  
involved_in negative regulation of epithelial cell proliferation  
involved_in negative regulation of monocyte differentiation  
involved_in negative regulation of myeloid cell differentiation  
involved_in negative regulation of osteoblast differentiation  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
involved_in positive regulation of cell-matrix adhesion  
involved_in positive regulation of fibroblast proliferation  
acts_upstream_of_or_within positive regulation of gene expression  
involved_in protein phosphorylation  
involved_in regulation of G2/M transition of mitotic cell cycle  
involved_in regulation of erythrocyte differentiation  
involved_in regulation of gene expression  
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation  
involved_in response to virus  
involved_in signal transduction  
involved_in type B pancreatic cell development  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in centrosome  
part_of cyclin D1-CDK6 complex  
part_of cyclin D2-CDK6 complex  
part_of cyclin D3-CDK6 complex  
part_of cyclin-dependent protein kinase holoenzyme complex  
part_of cyclin-dependent protein kinase holoenzyme complex  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in ruffle  

General protein information

Preferred Names
cyclin-dependent kinase 6
Names
cell division protein kinase 6
NP_001178790.1
XP_006236081.1
XP_006236082.1
XP_006236083.1
XP_038962838.1
XP_063141463.1
XP_063141464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191861.3NP_001178790.1  cyclin-dependent kinase 6

    See identical proteins and their annotated locations for NP_001178790.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Related
    ENSRNOP00000012597.5, ENSRNOT00000012597.8
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    31592384..31784732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236021.4XP_006236083.1  cyclin-dependent kinase 6 isoform X1

    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  2. XM_006236019.5XP_006236081.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236081.1

    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  3. XM_063285393.1XP_063141463.1  cyclin-dependent kinase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
  4. XM_006236020.5XP_006236082.1  cyclin-dependent kinase 6 isoform X1

    See identical proteins and their annotated locations for XP_006236082.1

    UniProtKB/TrEMBL
    A0A8I6A5X3, A6K295, F1MA87
    Conserved Domains (1) summary
    cd07862
    Location:11300
    STKc_CDK6; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6
  5. XM_063285394.1XP_063141464.1  cyclin-dependent kinase 6 isoform X2

  6. XM_039106910.2XP_038962838.1  cyclin-dependent kinase 6 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:11179
    PKc_like; Protein Kinases, catalytic domain
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