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Fbxo9 f-box protein 9 [ Mus musculus (house mouse) ]

Gene ID: 71538, updated on 4-Jan-2025

Summary

Official Symbol
Fbxo9provided by MGI
Official Full Name
f-box protein 9provided by MGI
Primary source
MGI:MGI:1918788
See related
Ensembl:ENSMUSG00000001366 AllianceGenome:MGI:1918788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030401P18Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within fat cell differentiation and innate immune response. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; and liver. Orthologous to human FBXO9 (F-box protein 9). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in cerebellum adult (RPKM 35.4), adrenal adult (RPKM 26.9) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxo9 in Genome Data Viewer
Location:
9 E1; 9 43.53 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77988781..78016347, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78081499..78109065, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glial cells missing homolog 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6773 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77960730-77961031 Neighboring gene STARR-seq mESC enhancer starr_24717 Neighboring gene ciliogenesis associated kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E41 Neighboring gene RNA, 7SK, nuclear

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex  
part_of SCF ubiquitin ligase complex  
part_of SCF ubiquitin ligase complex  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081490.2NP_001074959.1  F-box only protein 9 isoform 2

    See identical proteins and their annotated locations for NP_001074959.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC159313, AI847242, AK077607, DV657928
    Consensus CDS
    CCDS52864.1
    UniProtKB/Swiss-Prot
    Q8BK06, Q8VDY6, Q9D349, Q9JJC5
    Related
    ENSMUSP00000001402.8, ENSMUST00000001402.14
    Conserved Domains (2) summary
    pfam12937
    Location:178229
    F-box-like; F-box-like
    cl00299
    Location:82113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
  2. NM_023605.2NP_076094.2  F-box only protein 9 isoform 1

    See identical proteins and their annotated locations for NP_076094.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AC159313, AK077607, CX567646
    Consensus CDS
    CCDS52863.1
    UniProtKB/Swiss-Prot
    Q8BK06
    Related
    ENSMUSP00000082419.7, ENSMUST00000085311.13
    Conserved Domains (2) summary
    pfam12937
    Location:177228
    F-box-like; F-box-like
    cl00299
    Location:81112
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    77988781..78016347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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