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Lrp1 low density lipoprotein receptor-related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 16971, updated on 4-Jan-2025

Summary

Official Symbol
Lrp1provided by MGI
Official Full Name
low density lipoprotein receptor-related protein 1provided by MGI
Primary source
MGI:MGI:96828
See related
Ensembl:ENSMUSG00000040249 AllianceGenome:MGI:96828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrp; A2mr; CD91; b2b1554Clo
Summary
Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and negative regulation of Wnt signaling pathway. Located in external side of plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 53.9), liver adult (RPKM 50.5) and 27 other tissues See more
Orthologs
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Genomic context

See Lrp1 in Genome Data Viewer
Location:
10 D3; 10 74.52 cM
Exon count:
90
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127374026..127457158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127538157..127621148, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Ndufa4, mitochondrial complex associated like 2 Neighboring gene STARR-positive B cell enhancer ABC_E1132 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial) Neighboring gene neurexophilin 4 Neighboring gene STARR-seq mESC enhancer starr_28231 Neighboring gene predicted gene 16217 Neighboring gene STARR-seq mESC enhancer starr_28232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127078975-127079084 Neighboring gene predicted gene, 40802 Neighboring gene signal transducer and activator of transcription 6 Neighboring gene predicted gene, 30989

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-2 macroglobulin receptor activity  
enables alpha-2 macroglobulin receptor activity  
enables alpha-2 macroglobulin receptor activity  
enables apolipoprotein binding  
enables apolipoprotein binding  
enables apolipoprotein binding  
enables calcium ion binding PubMed 
enables calcium ion binding  
enables cargo receptor activity  
enables cargo receptor activity PubMed 
enables cargo receptor activity  
enables clathrin heavy chain binding  
enables clathrin heavy chain binding  
enables coreceptor activity  
enables protease binding  
enables protein binding PubMed 
enables protein-containing complex binding  
enables protein-containing complex binding  
enables signaling receptor binding PubMed 
Items 1 - 25 of 76
Process Evidence Code Pubs
involved_in amyloid-beta clearance PubMed 
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by cellular catabolic process PubMed 
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by cellular catabolic process PubMed 
involved_in amyloid-beta clearance by cellular catabolic process PubMed 
involved_in amyloid-beta clearance by cellular catabolic process  
involved_in amyloid-beta clearance by transcytosis  
involved_in amyloid-beta clearance by transcytosis PubMed 
involved_in amyloid-beta clearance by transcytosis  
involved_in amyloid-beta clearance by transcytosis  
involved_in aorta morphogenesis PubMed 
acts_upstream_of_or_within apoptotic cell clearance PubMed 
involved_in astrocyte activation involved in immune response PubMed 
acts_upstream_of_or_within cardiac septum development PubMed 
involved_in cellular response to amyloid-beta PubMed 
involved_in chemoattraction of axon  
acts_upstream_of_or_within cholesterol metabolic process PubMed 
acts_upstream_of_or_within coronary vasculature development PubMed 
involved_in enzyme-linked receptor protein signaling pathway PubMed 
involved_in lipid catabolic process  
involved_in lysosomal transport PubMed 
involved_in negative regulation of SMAD protein signal transduction PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cell-substrate adhesion  
involved_in negative regulation of cytosolic calcium ion concentration  
involved_in negative regulation of focal adhesion assembly  
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of neuron projection development  
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway PubMed 
involved_in negative regulation of smooth muscle cell migration PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
involved_in phagocytosis  
involved_in phagocytosis  
involved_in phagocytosis  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of Schwann cell migration  
involved_in positive regulation of amyloid-beta clearance PubMed 
involved_in positive regulation of axon extension  
involved_in positive regulation of axon extension involved in regeneration  
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
involved_in positive regulation of cholesterol efflux PubMed 
involved_in positive regulation of cholesterol import  
involved_in positive regulation of collateral sprouting of injured axon  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of endocytosis  
involved_in positive regulation of endocytosis  
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in positive regulation of lipid transport PubMed 
involved_in positive regulation of lysosomal protein catabolic process  
involved_in positive regulation of lysosomal protein catabolic process  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of phagocytosis  
involved_in positive regulation of protein binding  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein localization to plasma membrane  
involved_in positive regulation of protein transport  
involved_in positive regulation of transcytosis PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration  
involved_in receptor-mediated endocytosis  
acts_upstream_of_or_within receptor-mediated endocytosis PubMed 
involved_in receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis PubMed 
involved_in receptor-mediated endocytosis PubMed 
involved_in receptor-mediated endocytosis  
involved_in regulation of actin cytoskeleton organization PubMed 
involved_in regulation of cholesterol transport PubMed 
involved_in regulation of phospholipase A2 activity PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of pulmonary blood vessel remodeling PubMed 
involved_in transport across blood-brain barrier PubMed 
Items 1 - 25 of 76
Items 1 - 20 of 28
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in apical part of cell  
located_in axonal growth cone  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in clathrin-coated pit  
located_in clathrin-coated vesicle  
located_in dendrite  
located_in early endosome  
located_in early endosome  
located_in endosome  
located_in external side of plasma membrane PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in insulin-responsive compartment  
located_in membrane PubMed 
located_in microtubule organizing center  
located_in neuronal cell body  
located_in nucleus  
located_in perinuclear region of cytoplasm PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
is_active_in postsynaptic density membrane PubMed 
is_active_in postsynaptic density membrane PubMed 
part_of receptor complex  
part_of receptor complex PubMed 
Items 1 - 20 of 28

General protein information

Preferred Names
prolow-density lipoprotein receptor-related protein 1
Names
LRP-1
alpha 2-macroglobulin receptor
lipoprotein receptor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008512.2NP_032538.2  prolow-density lipoprotein receptor-related protein 1 precursor

    See identical proteins and their annotated locations for NP_032538.2

    Status: VALIDATED

    Source sequence(s)
    AC167719, AF367720, AK078273, AK154429, BU615020, CA888999, CB527265, CF535491, X67469
    Consensus CDS
    CCDS24245.1
    UniProtKB/Swiss-Prot
    Q61291, Q91ZX7, Q920Y4
    UniProtKB/TrEMBL
    A0A0R4J0I9
    Related
    ENSMUSP00000044004.9, ENSMUST00000049149.15
    Conserved Domains (8) summary
    smart00192
    Location:34943527
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:30953137
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:29833012
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22542464
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35763610
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:40144054
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29632986
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:808843
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127374026..127457158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155650.1XP_036011543.1  prolow-density lipoprotein receptor-related protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61291, Q91ZX7, Q920Y4
    Conserved Domains (8) summary
    smart00192
    Location:35113544
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:31123154
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:30003029
    EGF_CA; Calcium-binding EGF-like domain
    COG3386
    Location:22712481
    YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
    cd00112
    Location:35933627
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:40314071
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12662
    Location:29803003
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:808843
    FXa_inhibition; Coagulation Factor Xa inhibitory site
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