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Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [ Mus musculus (house mouse) ]

Gene ID: 18018, updated on 4-Jan-2025

Summary

Official Symbol
Nfatc1provided by MGI
Official Full Name
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1provided by MGI
Primary source
MGI:MGI:102469
See related
Ensembl:ENSMUSG00000033016 AllianceGenome:MGI:102469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; leukocyte differentiation; and negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; genitourinary system; heart; hemolymphoid system; and limb mesenchyme. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in spleen adult (RPKM 23.0), thymus adult (RPKM 14.6) and 15 other tissues See more
Orthologs
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Genomic context

See Nfatc1 in Genome Data Viewer
Location:
18 E3; 18 53.66 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80649418..80756286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80606205..80713071, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54039 Neighboring gene predicted gene, 41790 Neighboring gene predicted gene, 52342 Neighboring gene STARR-positive B cell enhancer mm9_chr18:80888627-80888928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:80935003-80935320 Neighboring gene ATPase, class II, type 9B Neighboring gene STARR-seq mESC enhancer starr_45180 Neighboring gene STARR-positive B cell enhancer ABC_E7617 Neighboring gene STARR-seq mESC enhancer starr_45183 Neighboring gene spalt like transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription factor binding PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
enables chromatin binding PubMed 
enables mitogen-activated protein kinase p38 binding PubMed 
enables nucleic acid binding  
enables protein binding PubMed 
enables sequence-specific DNA binding PubMed 
enables sequence-specific double-stranded DNA binding  
enables transcription coactivator binding  
Items 1 - 25 of 49
Process Evidence Code Pubs
acts_upstream_of_or_within B-1a B cell differentiation PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle PubMed 
involved_in aortic valve development PubMed 
acts_upstream_of_or_within aortic valve morphogenesis PubMed 
acts_upstream_of_or_within branching involved in lymph vessel morphogenesis PubMed 
involved_in calcineurin-NFAT signaling cascade  
acts_upstream_of_or_within calcineurin-NFAT signaling cascade PubMed 
involved_in calcineurin-NFAT signaling cascade  
acts_upstream_of_or_within calcium ion transport PubMed 
acts_upstream_of_or_within cell quiescence PubMed 
acts_upstream_of_or_within cellular response to calcium ion PubMed 
involved_in endocardial cushion development PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition PubMed 
acts_upstream_of_or_within gene expression PubMed 
acts_upstream_of_or_within heart development PubMed 
acts_upstream_of_or_within heart trabecula morphogenesis PubMed 
involved_in heart valve development PubMed 
acts_upstream_of_or_within heart valve morphogenesis PubMed 
acts_upstream_of_or_within intracellular signal transduction PubMed 
acts_upstream_of keratinocyte proliferation PubMed 
acts_upstream_of_or_within lymphangiogenesis PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of vascular associated smooth muscle cell differentiation  
acts_upstream_of_or_within osteoclast differentiation PubMed 
involved_in positive regulation of DNA biosynthetic process  
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
acts_upstream_of_or_within positive regulation of gene expression PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in pulmonary valve development PubMed 
acts_upstream_of_or_within pulmonary valve morphogenesis PubMed 
acts_upstream_of_or_within regulation of hair cycle PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in semi-lunar valve development PubMed 
acts_upstream_of stem cell proliferation PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
acts_upstream_of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within transition between fast and slow fiber PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis PubMed 
involved_in wound healing  
Items 1 - 25 of 49
Component Evidence Code Pubs
located_in chromatin  
is_active_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in nuclear body  
located_in nucleoplasm  
is_active_in nucleus  
is_active_in nucleus PubMed 
located_in nucleus PubMed 
located_in nucleus  
located_in perinuclear region of cytoplasm  
located_in sarcoplasm  
part_of transcription regulator complex  
part_of transcription regulator complex PubMed 

General protein information

Preferred Names
nuclear factor of activated T-cells, cytoplasmic 1
Names
NF-ATc1
NFAT transcription complex cytosolic component
transcription factor NF-ATc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164109.1NP_001157581.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 3

    See identical proteins and their annotated locations for NP_001157581.1

    Status: VALIDATED

    Source sequence(s)
    AI449492, AK048610, EU887570
    Consensus CDS
    CCDS89287.1
    UniProtKB/TrEMBL
    B5B2N5, Q3UME0
    Related
    ENSMUSP00000158358.2, ENSMUST00000236711.2
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. NM_001164110.1NP_001157582.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 4

    See identical proteins and their annotated locations for NP_001157582.1

    Status: VALIDATED

    Source sequence(s)
    AK048610, EU887567
    Consensus CDS
    CCDS50336.1
    UniProtKB/TrEMBL
    B5B2N2
    Related
    ENSMUSP00000129001.2, ENSMUST00000170905.9
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. NM_001164111.1NP_001157583.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 6

    See identical proteins and their annotated locations for NP_001157583.1

    Status: VALIDATED

    Source sequence(s)
    BB647702, EU887569
    Consensus CDS
    CCDS89286.1
    UniProtKB/Swiss-Prot
    O70345, O88942
    UniProtKB/TrEMBL
    B5B2N4, Q3UME0
    Related
    ENSMUSP00000158284.2, ENSMUST00000236310.2
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  4. NM_001164112.1NP_001157584.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 5

    See identical proteins and their annotated locations for NP_001157584.1

    Status: VALIDATED

    Source sequence(s)
    BB647702, EU887572
    Consensus CDS
    CCDS50335.1
    UniProtKB/TrEMBL
    B5B2N7
    Related
    ENSMUSP00000126884.2, ENSMUST00000167977.8
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  5. NM_016791.4NP_058071.2  nuclear factor of activated T-cells, cytoplasmic 1 isoform 1

    See identical proteins and their annotated locations for NP_058071.2

    Status: VALIDATED

    Source sequence(s)
    AI449492, BB647702, EU887571
    Consensus CDS
    CCDS29369.1
    UniProtKB/Swiss-Prot
    O70345, O88942
    UniProtKB/TrEMBL
    Q3UME0, Q9DBQ6
    Related
    ENSMUSP00000046312.8, ENSMUST00000035800.8
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  6. NM_198429.2NP_940821.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

    See identical proteins and their annotated locations for NP_940821.1

    Status: VALIDATED

    Source sequence(s)
    AK048610, EU887568
    Consensus CDS
    CCDS37873.1
    UniProtKB/TrEMBL
    Q3UME0, Q6P7T9
    Related
    ENSMUSP00000077196.5, ENSMUST00000078049.12
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80649418..80756286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161027.1XP_036016920.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X2

    UniProtKB/Swiss-Prot
    O70345, O88942
    UniProtKB/TrEMBL
    Q3UME0
    Conserved Domains (2) summary
    cd07881
    Location:425599
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:604704
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. XM_036161026.1XP_036016919.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1

    Conserved Domains (3) summary
    cd07881
    Location:425599
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    PHA03247
    Location:704897
    PHA03247; large tegument protein UL36; Provisional
    cl15674
    Location:604704
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. XM_036161029.1XP_036016922.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X3

    Conserved Domains (3) summary
    cd07881
    Location:9183
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    PHA03247
    Location:288481
    PHA03247; large tegument protein UL36; Provisional
    cl15674
    Location:188288
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
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