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Arhgef10 Rho guanine nucleotide exchange factor 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306618, updated on 4-Jan-2025

Summary

Official Symbol
Arhgef10provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 10provided by RGD
Primary source
RGD:1565043
See related
EnsemblRapid:ENSRNOG00000012561 AllianceGenome:RGD:1565043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565043
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and kinesin binding activity. Predicted to be involved in several processes, including activation of GTPase activity; cytoskeleton organization; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 104.2), Heart (RPKM 72.9) and 9 other tissues See more
Orthologs
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Genomic context

See Arhgef10 in Genome Data Viewer
Location:
16q12.5
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (81349429..81440439, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (74647147..74738784, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (79725629..79817065, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551089 Neighboring gene myomesin 2 Neighboring gene uncharacterized LOC102551149 Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene uncharacterized LOC134482526 Neighboring gene uncharacterized LOC102557538 Neighboring gene uncharacterized LOC134482525 Neighboring gene uncharacterized LOC134482527 Neighboring gene CLN8, transmembrane ER and ERGIC protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity  
enables guanyl-nucleotide exchange factor activity  
enables kinesin binding  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization  
involved_in activation of GTPase activity  
involved_in centrosome duplication  
involved_in mitotic spindle assembly  
involved_in mitotic spindle assembly  
involved_in myelination in peripheral nervous system  
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of stress fiber assembly  
Component Evidence Code Pubs
is_active_in centrosome  
located_in centrosome  
is_active_in cytoplasm  

General protein information

Preferred Names
rho guanine nucleotide exchange factor 10
Names
Rho guanine nucleotide exchange factor (GEF) 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427033.1NP_001413962.1  rho guanine nucleotide exchange factor 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IWD5, M0R3X3
    Related
    ENSRNOP00000064046.3, ENSRNOT00000073971.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    81349429..81440439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275478.1XP_063131548.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0S7, A6IWD5
  2. XM_006253400.5XP_006253462.1  rho guanine nucleotide exchange factor 10 isoform X1

    See identical proteins and their annotated locations for XP_006253462.1

    UniProtKB/TrEMBL
    A6IWD5, M0R3X3
    Conserved Domains (2) summary
    pfam00621
    Location:436614
    RhoGEF; RhoGEF domain
    cl17171
    Location:646712
    PH-like; Pleckstrin homology-like domain
  3. XM_006253403.5XP_006253465.1  rho guanine nucleotide exchange factor 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0S7, A6IWD5
    Related
    ENSRNOP00000085722.1, ENSRNOT00000119970.2
    Conserved Domains (2) summary
    pfam00621
    Location:400578
    RhoGEF; RhoGEF domain
    cl17171
    Location:610676
    PH-like; Pleckstrin homology-like domain
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