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DCUN1D1 defective in cullin neddylation 1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 54165, updated on 5-Jan-2025

Summary

Official Symbol
DCUN1D1provided by HGNC
Official Full Name
defective in cullin neddylation 1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18184
See related
Ensembl:ENSG00000043093 MIM:605905; AllianceGenome:HGNC:18184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
Summary
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues See more
Orthologs
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Genomic context

See DCUN1D1 in Genome Data Viewer
Location:
3q26.33
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (182938074..182985918, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (185743177..185791010, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182655862..182703706, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14932 Neighboring gene ATP11B divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182516660-182517160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182517161-182517661 Neighboring gene Sharpr-MPRA regulatory region 857 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene EIF3E pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20883 Neighboring gene C9orf85 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14935 Neighboring gene uncharacterized LOC105374246 Neighboring gene uncharacterized LOC124906309 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20884 Neighboring gene uncharacterized LOC105374247

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding  
enables cullin family protein binding PubMed 
enables protein binding PubMed 
enables ubiquitin conjugating enzyme binding  
enables ubiquitin-like protein binding  
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleus PubMed 
part_of ubiquitin ligase complex  
part_of ubiquitin ligase complex PubMed 

General protein information

Preferred Names
DCN1-like protein 1
Names
DCN1, defective in cullin neddylation 1, domain containing 1
DCUN1 domain-containing protein 1
RP42 homolog
defective in cullin neddylation protein 1-like protein 1
squamous cell carcinoma-related oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308101.2NP_001295030.1  DCN1-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001295030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047
    Consensus CDS
    CCDS77862.1
    UniProtKB/TrEMBL
    B4DM76, C9JUW4, C9JVE2
    Related
    ENSP00000419359.1, ENST00000469954.5
    Conserved Domains (2) summary
    pfam03556
    Location:121231
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  2. NM_020640.4NP_065691.2  DCN1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065691.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603
    Consensus CDS
    CCDS3240.1
    UniProtKB/Swiss-Prot
    B2RB37, Q7L3G9, Q8TEX7, Q96GG9, Q9H6M1, Q9HCT3
    UniProtKB/TrEMBL
    B4DM76
    Related
    ENSP00000292782.4, ENST00000292782.9
    Conserved Domains (2) summary
    pfam03556
    Location:136246
    Cullin_binding; Cullin binding
    cl21463
    Location:151
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    182938074..182985918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453601.2XP_024309369.2  DCN1-like protein 1 isoform X4

  2. XM_047448339.1XP_047304295.1  DCN1-like protein 1 isoform X2

    UniProtKB/TrEMBL
    B4DM76
  3. XM_011512914.2XP_011511216.1  DCN1-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011511216.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  4. XM_011512915.3XP_011511217.1  DCN1-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011511217.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  5. XM_011512916.3XP_011511218.1  DCN1-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011511218.1

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily
  6. XM_047448340.1XP_047304296.1  DCN1-like protein 1 isoform X3

  7. XM_047448338.1XP_047304294.1  DCN1-like protein 1 isoform X1

  8. XM_011512912.3XP_011511214.1  DCN1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011511214.1

    Conserved Domains (2) summary
    pfam03556
    Location:136234
    Cullin_binding; Cullin binding
    cl21463
    Location:151
    UBA_like_SF; UBA domain-like superfamily
  9. XM_017006634.1XP_016862123.1  DCN1-like protein 1 isoform X3

    Conserved Domains (2) summary
    pfam03556
    Location:121219
    Cullin_binding; Cullin binding
    cl21463
    Location:136
    UBA_like_SF; UBA domain-like superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    185743177..185791010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346910.1XP_054202885.1  DCN1-like protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DM76, C9JUW4, C9JVE2
  2. XM_054346906.1XP_054202881.1  DCN1-like protein 1 isoform X2

    UniProtKB/TrEMBL
    B4DM76
  3. XM_054346907.1XP_054202882.1  DCN1-like protein 1 isoform X3

  4. XM_054346909.1XP_054202884.1  DCN1-like protein 1 isoform X3

  5. XM_054346905.1XP_054202880.1  DCN1-like protein 1 isoform X1

  6. XM_054346904.1XP_054202879.1  DCN1-like protein 1 isoform X1

  7. XM_054346908.1XP_054202883.1  DCN1-like protein 1 isoform X3

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