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Nfe2l2 nuclear factor, erythroid derived 2, like 2 [ Mus musculus (house mouse) ]

Gene ID: 18024, updated on 4-Jan-2025

Summary

Official Symbol
Nfe2l2provided by MGI
Official Full Name
nuclear factor, erythroid derived 2, like 2provided by MGI
Primary source
MGI:MGI:108420
See related
Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrf2
Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 57.1), duodenum adult (RPKM 26.8) and 26 other tissues See more
Orthologs
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Genomic context

See Nfe2l2 in Genome Data Viewer
Location:
2 C3; 2 44.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (75505860..75535007, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (75675513..75704663, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39859 Neighboring gene STARR-seq mESC enhancer starr_04867 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 Neighboring gene STARR-seq mESC enhancer starr_04869 Neighboring gene RIKEN cDNA E030042O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1590 Neighboring gene STARR-positive B cell enhancer ABC_E4469 Neighboring gene STARR-positive B cell enhancer ABC_E9069 Neighboring gene STARR-seq mESC enhancer starr_04874 Neighboring gene STARR-seq mESC enhancer starr_04876 Neighboring gene STARR-seq mESC enhancer starr_04877 Neighboring gene predicted gene, 34657

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA binding  
enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific  
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables RNA polymerase II-specific DNA-binding transcription factor binding  
enables molecular condensate scaffold activity  
enables molecular condensate scaffold activity  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding  
enables sequence-specific DNA binding PubMed 
enables sequence-specific DNA binding  
enables transcription cis-regulatory region binding PubMed 
enables transcription cis-regulatory region binding  
enables transcription coregulator binding  
enables transcription coregulator binding  
enables transcription factor binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 75
Process Evidence Code Pubs
involved_in PERK-mediated unfolded protein response PubMed 
involved_in aflatoxin catabolic process  
involved_in aflatoxin catabolic process  
involved_in cell redox homeostasis PubMed 
involved_in cell redox homeostasis  
involved_in cell redox homeostasis  
involved_in cellular response to angiotensin  
involved_in cellular response to angiotensin  
acts_upstream_of_or_within cellular response to copper ion PubMed 
involved_in cellular response to fluid shear stress  
involved_in cellular response to fluid shear stress  
involved_in cellular response to glucose starvation PubMed 
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to hypoxia  
involved_in cellular response to hypoxia  
involved_in cellular response to laminar fluid shear stress  
involved_in cellular response to laminar fluid shear stress  
involved_in cellular response to methionine  
involved_in cellular response to oxidative stress  
involved_in cellular response to oxidative stress PubMed 
acts_upstream_of_or_within cellular response to oxidative stress PubMed 
involved_in cellular response to tumor necrosis factor  
involved_in cellular response to tumor necrosis factor  
acts_upstream_of_or_within cellular response to xenobiotic stimulus PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response PubMed 
acts_upstream_of_or_within inflammatory response PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process  
involved_in negative regulation of cardiac muscle cell apoptotic process  
involved_in negative regulation of cellular response to hypoxia  
involved_in negative regulation of cellular response to hypoxia  
involved_in negative regulation of endothelial cell apoptotic process  
involved_in negative regulation of endothelial cell apoptotic process  
involved_in negative regulation of ferroptosis  
involved_in negative regulation of ferroptosis  
involved_in negative regulation of hematopoietic stem cell differentiation PubMed 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
involved_in negative regulation of vascular associated smooth muscle cell migration  
involved_in negative regulation of vascular associated smooth muscle cell migration  
involved_in positive regulation of D-glucose import PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of blood coagulation PubMed 
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression  
involved_in positive regulation of glutathione biosynthetic process PubMed 
involved_in positive regulation of neuron projection development  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of reactive oxygen species metabolic process PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in proteasomal ubiquitin-independent protein catabolic process  
involved_in proteasomal ubiquitin-independent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in protein ubiquitination  
involved_in protein ubiquitination  
acts_upstream_of_or_within reactive oxygen species metabolic process PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
involved_in regulation of cellular response to oxidative stress  
acts_upstream_of_or_within regulation of embryonic development PubMed 
involved_in regulation of innate immune response PubMed 
involved_in regulation of removal of superoxide radicals PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in response to endoplasmic reticulum stress PubMed 
involved_in response to ischemia  
involved_in response to oxidative stress  
Items 1 - 25 of 75
Items 1 - 20 of 26
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
part_of RNA polymerase II transcription regulator complex  
part_of RNA polymerase II transcription regulator complex  
located_in centrosome  
located_in centrosome  
located_in chromatin PubMed 
located_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol PubMed 
is_active_in cytosol PubMed 
located_in cytosol  
located_in cytosol  
part_of mediator complex  
is_active_in membraneless organelle  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in plasma membrane  
located_in plasma membrane  
part_of protein-DNA complex PubMed 
part_of transcription regulator complex PubMed 
Items 1 - 20 of 26

General protein information

Preferred Names
nuclear factor erythroid 2-related factor 2
Names
NF-E2-related factor 2
NFE2-related factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399226.1NP_001386155.1  nuclear factor erythroid 2-related factor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several alternate 3' exons and uses an alternate 3' terminal exon, compared to variant 1.
    Source sequence(s)
    AL772404
    Related
    ENSMUST00000152371.2
  2. NM_010902.5NP_035032.1  nuclear factor erythroid 2-related factor 2 isoform 1

    See identical proteins and their annotated locations for NP_035032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL772404
    Consensus CDS
    CCDS16150.1
    UniProtKB/Swiss-Prot
    Q3UQK0, Q60795
    Related
    ENSMUSP00000099733.5, ENSMUST00000102672.5
    Conserved Domains (1) summary
    cd14720
    Location:486553
    bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    75505860..75535007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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