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Mpp7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) [ Mus musculus (house mouse) ]

Gene ID: 75739, updated on 4-Jan-2025

Summary

Official Symbol
Mpp7provided by MGI
Official Full Name
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)provided by MGI
Primary source
MGI:MGI:1922989
See related
Ensembl:ENSMUSG00000057440 AllianceGenome:MGI:1922989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm955; 1110068J02Rik; 2810038M04Rik; 5430426E14Rik
Summary
Predicted to enable molecular adaptor activity and protein domain specific binding activity. Predicted to be involved in bicellular tight junction assembly; positive regulation of protein-containing complex assembly; and protein localization to adherens junction. Predicted to be located in adherens junction; bicellular tight junction; and nucleoplasm. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human MPP7 (MAGUK p55 scaffold protein 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in bladder adult (RPKM 2.7), cerebellum adult (RPKM 1.8) and 22 other tissues See more
Orthologs
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Genomic context

See Mpp7 in Genome Data Viewer
Location:
18 A1; 18 4.53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (7347962..7627017, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (7347962..7626889, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18581 Neighboring gene outer dynein arm docking complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_43732 Neighboring gene predicted gene, 34979 Neighboring gene STARR-seq mESC enhancer starr_43733 Neighboring gene STARR-seq mESC enhancer starr_43734 Neighboring gene STARR-positive B cell enhancer mm9_chr18:7497579-7497879 Neighboring gene STARR-seq mESC enhancer starr_43735 Neighboring gene STARR-seq mESC enhancer starr_43736 Neighboring gene MAD2 mitotic arrest deficient-like 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr18:7609231-7609532 Neighboring gene STARR-positive B cell enhancer ABC_E4238 Neighboring gene fatty acid binding protein 5-like 2 Neighboring gene STARR-seq mESC enhancer starr_43740 Neighboring gene STARR-seq mESC enhancer starr_43741 Neighboring gene STARR-seq mESC enhancer starr_43742 Neighboring gene STARR-seq mESC enhancer starr_43743 Neighboring gene STARR-seq mESC enhancer starr_43745 Neighboring gene round spermatid basic protein 1-like pseudogene Neighboring gene high mobility group AT-hook I, related sequence 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity  
enables molecular adaptor activity  
enables protein domain specific binding  
enables protein domain specific binding  
Component Evidence Code Pubs
part_of MPP7-DLG1-LIN7 complex  
part_of MPP7-DLG1-LIN7 complex  
located_in adherens junction  
located_in adherens junction  
located_in bicellular tight junction  
located_in bicellular tight junction  
located_in cell cortex  
located_in cell junction  
is_active_in cell-cell junction  
located_in lateral plasma membrane  
located_in nucleoplasm  
is_active_in plasma membrane  

General protein information

Preferred Names
MAGUK p55 subfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081287.2NP_001074756.2  MAGUK p55 subfamily member 7 isoform 1

    See identical proteins and their annotated locations for NP_001074756.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC138529, AK027937, AK078849, AV260217, CN457430
    Consensus CDS
    CCDS50217.1
    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    UniProtKB/TrEMBL
    G5E8S8
    Related
    ENSMUSP00000111535.3, ENSMUST00000115869.4
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:378563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001161620.1NP_001155092.1  MAGUK p55 subfamily member 7 isoform 2

    See identical proteins and their annotated locations for NP_001155092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AK027937, AK078849
    Consensus CDS
    CCDS89187.1
    UniProtKB/TrEMBL
    A0A3Q4EGM2
    Related
    ENSMUSP00000157306.2, ENSMUST00000234571.2
    Conserved Domains (3) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001360860.1NP_001347789.1  MAGUK p55 subfamily member 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Both variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC138529, AC139157, AC139324
    Consensus CDS
    CCDS50217.1
    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    UniProtKB/TrEMBL
    G5E8S8
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:378563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    7347962..7627017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526326.5XP_006526389.1  MAGUK p55 subfamily member 7 isoform X3

    See identical proteins and their annotated locations for XP_006526389.1

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    UniProtKB/TrEMBL
    G5E8S8
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:378563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_006526325.5XP_006526388.1  MAGUK p55 subfamily member 7 isoform X2

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:402587
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_006526327.4XP_006526390.1  MAGUK p55 subfamily member 7 isoform X4

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:386561
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_011247025.4XP_011245327.1  MAGUK p55 subfamily member 7 isoform X1

    See identical proteins and their annotated locations for XP_011245327.1

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:403588
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_017318006.3XP_017173495.1  MAGUK p55 subfamily member 7 isoform X1

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:403588
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  6. XM_036161304.1XP_036017197.1  MAGUK p55 subfamily member 7 isoform X3

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    UniProtKB/TrEMBL
    G5E8S8
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:378563
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  7. XM_011247026.2XP_011245328.1  MAGUK p55 subfamily member 7 isoform X1

    See identical proteins and their annotated locations for XP_011245328.1

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:403588
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  8. XM_011247027.3XP_011245329.1  MAGUK p55 subfamily member 7 isoform X1

    See identical proteins and their annotated locations for XP_011245329.1

    UniProtKB/Swiss-Prot
    Q148N6, Q8BVD5, Q8BZZ8, Q9D3K2
    Conserved Domains (4) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    smart00072
    Location:403588
    GuKc; Guanylate kinase homologues
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  9. XM_006526329.4XP_006526392.1  MAGUK p55 subfamily member 7 isoform X6

    Conserved Domains (1) summary
    smart00072
    Location:165350
    GuKc; Guanylate kinase homologues
  10. XM_017318008.2XP_017173497.1  MAGUK p55 subfamily member 7 isoform X5

    Conserved Domains (1) summary
    smart00072
    Location:166351
    GuKc; Guanylate kinase homologues
  11. XM_006526330.5XP_006526393.1  MAGUK p55 subfamily member 7 isoform X7

    UniProtKB/TrEMBL
    A0A3Q4EH71
    Conserved Domains (3) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  12. XM_017318009.2XP_017173498.1  MAGUK p55 subfamily member 7 isoform X8

    UniProtKB/TrEMBL
    A0A3Q4EH71
    Related
    ENSMUSP00000157345.2, ENSMUST00000234812.2
    Conserved Domains (3) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  13. XM_017318010.2XP_017173499.1  MAGUK p55 subfamily member 7 isoform X9

    UniProtKB/TrEMBL
    A0A3Q4EH71
    Conserved Domains (3) summary
    smart00569
    Location:1668
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12033
    Location:232292
    SH3_MPP7; Src Homology 3 domain of Membrane Protein, Palmitoylated 7 (or MAGUK p55 subfamily member 7)
    cd00992
    Location:137217
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_004939887.1 RNA Sequence

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